Protein : Qrob_P0591810.2 Q. robur
Protein Identifier  ? Qrob_P0591810.2 Organism . Name  Quercus robur
Score  0.0 Score Type  egn
Protein Description  (M=1) KOG0968//KOG0969 - DNA polymerase zeta catalytic subunit [Replication recombination and repair]. // DNA polymerase delta catalytic subunit [Replication recombination and repair]. Code Enzyme  EC:2.7.7.7
Gene Prediction Quality  validated Protein length 

Sequence

Length: 1292  
Kegg Orthology  K02350
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0 Synonyms

5 GO Terms

Identifier Name Description
GO:0003676 nucleic acid binding Interacting selectively and non-covalently with any nucleic acid.
GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
GO:0008408 3'-5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
GO:0016035 zeta DNA polymerase complex A heterodimeric DNA polymerase complex that catalyzes error-prone DNA synthesis in contexts such as translesion synthesis and double-stranded break repair. First characterized in Saccharomyces, in which the subunits are Rev3p and Rev7p; a third protein, Rev1p, is often associated with the polymerase dimer.
GO:0019985 translesion synthesis The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide.

19 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|mdm:103451319 71 1291 + 1221 Gaps:240 57.21 2068 51.48 0.0 DNA polymerase zeta catalytic subunit-like
blastp_kegg lcl|tcc:TCM_026537 72 1291 + 1220 Gaps:203 63.64 2035 46.72 0.0 Recovery protein 3 isoform 1
blastp_kegg lcl|gmx:100777934 56 1291 + 1236 Gaps:258 63.36 1976 43.85 0.0 DNA polymerase zeta catalytic subunit-like
blastp_kegg lcl|csv:101222413 71 1291 + 1221 Gaps:231 44.77 2868 40.11 0.0 uncharacterized LOC101222413
blastp_kegg lcl|pmum:103344607 8 1287 + 1280 Gaps:178 40.05 2699 53.93 9e-179 DNA polymerase zeta catalytic subunit
blastp_kegg lcl|pper:PRUPE_ppa000111mg 8 1290 + 1283 Gaps:241 57.65 1771 54.36 1e-172 hypothetical protein
blastp_kegg lcl|cit:102622531 8 1291 + 1284 Gaps:165 56.80 1808 49.46 1e-170 DNA polymerase zeta catalytic subunit-like
blastp_kegg lcl|pop:POPTR_0013s02320g 8 1291 + 1284 Gaps:238 59.35 1855 47.77 1e-165 POPTRDRAFT_240745 POPTRDRAFT_729606 hypothetical protein
blastp_kegg lcl|cic:CICLE_v10003639mg 8 1291 + 1284 Gaps:230 55.14 1741 49.79 3e-164 hypothetical protein
blastp_kegg lcl|mtr:MTR_7g113390 71 1015 + 945 Gaps:281 96.17 1096 38.05 1e-159 DNA polymerase
blastp_uniprot_sprot sp|Q766Z3|REV3_ARATH 8 1291 + 1284 Gaps:239 60.95 1890 39.15 3e-100 DNA polymerase zeta catalytic subunit OS Arabidopsis thaliana GN REV3 PE 2 SV 1
blastp_uniprot_sprot sp|O60673|DPOLZ_HUMAN 82 1260 + 1179 Gaps:81 11.88 3130 36.02 1e-23 DNA polymerase zeta catalytic subunit OS Homo sapiens GN REV3L PE 1 SV 2
blastp_uniprot_sprot sp|Q61493|DPOLZ_MOUSE 82 1260 + 1179 Gaps:83 11.92 3122 35.22 7e-22 DNA polymerase zeta catalytic subunit OS Mus musculus GN Rev3l PE 1 SV 3
blastp_uniprot_sprot sp|P14284|DPOZ_YEAST 71 1262 + 1192 Gaps:68 22.61 1504 24.71 3e-07 DNA polymerase zeta catalytic subunit OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN REV3 PE 1 SV 1
rpsblast_cdd gnl|CDD|99821 1129 1265 + 137 Gaps:8 62.77 231 37.24 4e-30 cd05778 DNA_polB_zeta_exo inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta a family-B DNA polymerase. The 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta. DNA polymerase zeta is a family-B DNA polymerase which is distantly related to DNA polymerase delta. It plays a major role in translesion replication and the production of either spontaneous or induced mutations. In addition DNA polymerase zeta also appears to be involved in somatic hypermutability in B lymphocytes an important element for the production of high affinity antibodies in response to an antigen. The catalytic subunit contains both polymerase and 3'-5' exonuclease domains but only exhibits polymerase activity. The DnaQ-like 3'-5' exonuclease domain contains three sequence motifs termed ExoI ExoII and ExoIII without the four conserved acidic residues that are crucial for metal binding and catalysis.
rpsblast_cdd gnl|CDD|176646 1149 1257 + 109 Gaps:5 52.26 199 35.58 3e-08 cd05160 DEDDy_DNA_polB_exo DEDDy 3'-5' exonuclease domain of family-B DNA polymerases. The 3'-5' exonuclease domain of family-B DNA polymerases. This domain has a fundamental role in reducing polymerase errors and is involved in proofreading activity. Family-B DNA polymerases contain an N-terminal DEDDy DnaQ-like exonuclease domain in the same polypeptide chain as the polymerase domain similar to family-A DNA polymerases. This domain contains three sequence motifs termed ExoI ExoII and ExoIII with a specific YX(3)D pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. The exonuclease domain of family B polymerase also contains a beta hairpin structure that plays an important role in active site switching in the event of nucleotide misincorporation. Members include Escherichia coli DNA polymerase II some eubacterial phage DNA polymerases nuclear replicative DNA polymerases (alpha delta epsilon and zeta) and eukaryotic viral and plasmid-borne enzymes. Nuclear DNA polymerases alpha and zeta lack the four conserved acidic metal-binding residues. Family-B DNA polymerases are predominantly involved in DNA replication and DNA repair.
rpsblast_cdd gnl|CDD|30766 1132 1257 + 126 Gaps:15 14.02 792 29.73 5e-07 COG0417 PolB DNA polymerase elongation subunit (family B) [DNA replication recombination and repair].
rpsblast_kog gnl|CDD|36186 979 1257 + 279 Gaps:26 18.88 1488 28.83 3e-34 KOG0968 KOG0968 KOG0968 DNA polymerase zeta catalytic subunit [Replication recombination and repair].
rpsblast_kog gnl|CDD|36187 52 1243 + 1192 Gaps:41 26.92 1066 25.78 3e-07 KOG0969 KOG0969 KOG0969 DNA polymerase delta catalytic subunit [Replication recombination and repair].

10 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Gene3D 1131 1257 127 G3DSA:3.30.420.10 none none IPR012337
SUPERFAMILY 73 198 126 SSF53098 none none IPR012337
SUPERFAMILY 1130 1258 129 SSF53098 none none IPR012337
PANTHER 1108 1257 150 PTHR10322 none none none
PANTHER 269 525 257 PTHR10322 none none none
PANTHER 59 214 156 PTHR10322 none none none
Pfam 1133 1253 121 PF03104 "KEGG:00230+2.7.7.7","KEGG:00240+2.7.7.7" DNA polymerase family B, exonuclease domain IPR006133
PANTHER 1108 1257 150 PTHR10322:SF5 "KEGG:00230+2.7.7.7","KEGG:00240+2.7.7.7";signature_desc=DNA POLYMERASE ZETA CATALYTIC SUBUNIT none IPR030559
PANTHER 269 525 257 PTHR10322:SF5 "KEGG:00230+2.7.7.7","KEGG:00240+2.7.7.7";signature_desc=DNA POLYMERASE ZETA CATALYTIC SUBUNIT none IPR030559
PANTHER 59 214 156 PTHR10322:SF5 "KEGG:00230+2.7.7.7","KEGG:00240+2.7.7.7";signature_desc=DNA POLYMERASE ZETA CATALYTIC SUBUNIT none IPR030559

0 Localization

6 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran2_2014_nLBD*_A4 Qrob_Chr08 8 v_12498_318 v_12364_308 34,91 16,12 53,62 lod 2,4961 5,2
Bourran2_2014_rEpiBC*_A4 Qrob_Chr08 8 v_12498_318 v_12364_308 35,77 14,11 55,31 lod 2,9413 6,2
Bourran_2000_2002_QTL6_Delta.F Qrob_Chr03 3 s_2HYXJ2_207 s_1AUAXK_317 29.12 6,3 45,37 lod 3.1666 0.026
Bourran2_2014_nLBD_3P Qrob_Chr03 3 s_1ET7H8_604 s_1BYNB5_834 23,73 0 46,72 lod 1,7573 3,8
PM_1999_QTL14_peak_Bud_burst_3P Qrob_Chr03 3 s_2F0SI1_756 v_6056_735 11,78 3,78 50,78 lod 2,5 4,5
Bourran2_2014_rEpiBC*_3P Qrob_Chr03 3 s_1A3B3X_1163 s_1DKGMO_450 23,04 4,92 41,12 lod 2,5668 7

0 Targeting