Protein : Qrob_P0570720.2 Q. robur
Protein Identifier  ? Qrob_P0570720.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=2) 3.2.2.21 - DNA-3-methyladenine glycosylase II. Code Enzyme  EC:3.2.2.21
Gene Prediction Quality  validated Protein length 

Sequence

Length: 307  
Kegg Orthology  K01247
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0 Synonyms

3 GO Terms

Identifier Name Description
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.

30 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|rcu:RCOM_0536110 28 300 + 273 Gaps:34 85.36 280 69.46 5e-111 DNA-3-methyladenine glycosylase putative (EC:3.2.2.21)
blastp_kegg lcl|mdm:103401480 17 301 + 285 Gaps:30 96.96 263 67.45 6e-111 DNA-3-methyladenine glycosylase 1-like
blastp_kegg lcl|pper:PRUPE_ppa010112mg 25 301 + 277 Gaps:32 93.92 263 69.64 7e-111 hypothetical protein
blastp_kegg lcl|pxb:103939209 25 301 + 277 Gaps:30 93.92 263 69.64 1e-110 DNA-3-methyladenine glycosylase 1-like
blastp_kegg lcl|pmum:103340095 20 301 + 282 Gaps:32 95.82 263 70.24 2e-110 DNA-3-methyladenine glycosylase 1
blastp_kegg lcl|cic:CICLE_v10026218mg 25 301 + 277 Gaps:21 90.14 284 65.62 3e-110 hypothetical protein
blastp_kegg lcl|cit:102629620 25 301 + 277 Gaps:21 90.14 284 65.62 3e-110 DNA-3-methyladenine glycosylase 1-like
blastp_kegg lcl|pxb:103932817 25 301 + 277 Gaps:30 93.92 263 70.04 5e-110 DNA-3-methyladenine glycosylase 1-like
blastp_kegg lcl|cmo:103485049 18 303 + 286 Gaps:22 90.78 293 64.66 1e-108 probable DNA-3-methyladenine glycosylase 2
blastp_kegg lcl|sot:102588134 11 301 + 291 Gaps:3 79.56 362 57.99 6e-108 probable DNA-3-methyladenine glycosylase 2-like
blastp_pdb 3s6i_D 115 295 + 181 Gaps:8 79.39 228 33.70 5e-29 mol:protein length:228 DNA-3-methyladenine glycosylase 1
blastp_pdb 3s6i_A 115 295 + 181 Gaps:8 79.39 228 33.70 5e-29 mol:protein length:228 DNA-3-methyladenine glycosylase 1
blastp_pdb 2h56_C 134 295 + 162 Gaps:1 69.10 233 36.65 1e-26 mol:protein length:233 DNA-3-methyladenine glycosidase
blastp_pdb 2h56_B 134 295 + 162 Gaps:1 69.10 233 36.65 1e-26 mol:protein length:233 DNA-3-methyladenine glycosidase
blastp_pdb 2h56_A 134 295 + 162 Gaps:1 69.10 233 36.65 1e-26 mol:protein length:233 DNA-3-methyladenine glycosidase
blastp_pdb 2yg9_B 67 294 + 228 Gaps:25 91.11 225 36.10 3e-26 mol:protein length:225 DNA-3-METHYLADENINE GLYCOSIDASE II PUTATIVE
blastp_pdb 2yg9_A 67 294 + 228 Gaps:25 91.11 225 36.10 3e-26 mol:protein length:225 DNA-3-METHYLADENINE GLYCOSIDASE II PUTATIVE
blastp_pdb 2yg8_B 67 294 + 228 Gaps:25 91.11 225 36.10 3e-26 mol:protein length:225 DNA-3-METHYLADENINE GLYCOSIDASE II PUTATIVE
blastp_pdb 2yg8_A 67 294 + 228 Gaps:25 91.11 225 36.10 3e-26 mol:protein length:225 DNA-3-METHYLADENINE GLYCOSIDASE II PUTATIVE
blastp_pdb 2jhn_B 135 279 + 145 Gaps:15 50.17 295 29.73 7e-06 mol:protein length:295 3-METHYLADENINE DNA-GLYCOSYLASE
blastp_uniprot_sprot sp|Q92383|MAG1_SCHPO 115 295 + 181 Gaps:8 79.39 228 33.70 2e-28 DNA-3-methyladenine glycosylase 1 OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN mag1 PE 1 SV 1
blastp_uniprot_sprot sp|O31544|YFJP_BACSU 88 298 + 211 Gaps:16 79.09 287 29.07 2e-25 Putative DNA-3-methyladenine glycosylase YfjP OS Bacillus subtilis (strain 168) GN yfjP PE 3 SV 1
blastp_uniprot_sprot sp|O94468|MAG2_SCHPO 104 296 + 193 Gaps:3 92.02 213 27.55 4e-24 Probable DNA-3-methyladenine glycosylase 2 OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN mag2 PE 1 SV 1
blastp_uniprot_sprot sp|P22134|MAG_YEAST 98 302 + 205 Gaps:49 82.43 296 31.15 1e-18 DNA-3-methyladenine glycosylase OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN MAG1 PE 1 SV 1
blastp_uniprot_sprot sp|P37878|3MGA_BACSU 135 297 + 163 Gaps:9 56.77 303 25.58 3e-11 DNA-3-methyladenine glycosylase OS Bacillus subtilis (strain 168) GN alkA PE 1 SV 1
rpsblast_cdd gnl|CDD|30471 84 302 + 219 Gaps:12 81.05 285 35.06 2e-43 COG0122 AlkA 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication recombination and repair].
rpsblast_cdd gnl|CDD|201417 141 284 + 144 Gaps:11 97.92 144 31.21 3e-29 pfam00730 HhH-GPD HhH-GPD superfamily base excision DNA repair protein. This family contains a diverse range of structurally related DNA repair proteins. The superfamily is called the HhH-GPD family after its hallmark Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate. This includes endonuclease III EC:4.2.99.18 and MutY an A/G-specific adenine glycosylase both have a C terminal 4Fe-4S cluster. The family also includes 8-oxoguanine DNA glycosylases. The methyl-CPG binding protein MBD4 also contains a related domain that is a thymine DNA glycosylase. The family also includes DNA-3-methyladenine glycosylase II EC:3.2.2.21 and other members of the AlkA family.
rpsblast_cdd gnl|CDD|28938 135 296 + 162 Gaps:15 99.37 158 31.21 4e-24 cd00056 ENDO3c endonuclease III includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase) alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases.
rpsblast_cdd gnl|CDD|197751 145 294 + 150 Gaps:23 95.97 149 23.78 6e-14 smart00478 ENDO3c endonuclease III. includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase) alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases.
rpsblast_kog gnl|CDD|37129 80 300 + 221 Gaps:3 87.40 254 46.40 1e-65 KOG1918 KOG1918 KOG1918 3-methyladenine DNA glycosidase [Replication recombination and repair].

7 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
PANTHER 84 303 220 PTHR10242 none none none
Gene3D 246 298 53 G3DSA:1.10.1670.10 none none IPR023170
SUPERFAMILY 128 296 169 SSF48150 "Reactome:REACT_216" none IPR011257
Pfam 140 284 145 PF00730 "Reactome:REACT_216" HhH-GPD superfamily base excision DNA repair protein IPR003265
PANTHER 84 303 220 PTHR10242:SF0 none none none
SMART 143 298 156 SM00478 "Reactome:REACT_216" endonuclease III IPR003265
Gene3D 134 244 111 G3DSA:1.10.340.30 "Reactome:REACT_216" none IPR011257

0 Localization

0 Qtllist

0 Targeting