Protein : Qrob_P0372200.2 Q. robur
Protein Identifier  ? Qrob_P0372200.2 Organism . Name  Quercus robur
Score  4.5 Score Type  egn
Protein Description  (M=2) 3.2.2.21 - DNA-3-methyladenine glycosylase II. Code Enzyme  EC:3.2.2.21
Gene Prediction Quality  validated Protein length 

Sequence

Length: 379  
Kegg Orthology  K01247
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0 Synonyms

3 GO Terms

Identifier Name Description
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.

29 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|gmx:100790760 1 345 + 345 Gaps:30 86.36 374 76.47 2e-173 probable DNA-3-methyladenine glycosylase 2-like
blastp_kegg lcl|gmx:100788160 60 345 + 286 Gaps:7 79.49 351 82.08 2e-168 DNA-3-methyladenine glycosylase 1-like
blastp_kegg lcl|tcc:TCM_034050 1 331 + 331 Gaps:15 87.15 397 69.65 3e-166 DNA glycosylase superfamily protein
blastp_kegg lcl|cam:101502665 1 344 + 344 Gaps:27 89.32 384 69.97 9e-166 DNA-3-methyladenine glycosylase 1-like
blastp_kegg lcl|pvu:PHAVU_009G058200g 26 345 + 320 Gaps:22 83.61 366 75.49 1e-165 hypothetical protein
blastp_kegg lcl|rcu:RCOM_1594450 60 357 + 298 Gaps:21 76.15 369 81.85 6e-163 DNA-3-methyladenine glycosylase putative (EC:3.2.2.21)
blastp_kegg lcl|vvi:100243712 1 345 + 345 Gaps:22 88.98 363 71.21 7e-159 DNA-3-methyladenine glycosylase 1-like
blastp_kegg lcl|pxb:103929438 1 339 + 339 Gaps:18 90.19 367 69.79 7e-157 probable DNA-3-methyladenine glycosylase 2
blastp_kegg lcl|cmo:103503942 33 326 + 294 Gaps:16 78.10 379 77.03 4e-156 DNA-3-methyladenine glycosylase 1
blastp_kegg lcl|csv:101202943 33 326 + 294 Gaps:16 77.49 382 77.03 1e-155 uncharacterized LOC101202943
blastp_pdb 2h56_C 143 327 + 185 Gaps:1 78.97 233 33.70 1e-26 mol:protein length:233 DNA-3-methyladenine glycosidase
blastp_pdb 2h56_B 143 327 + 185 Gaps:1 78.97 233 33.70 1e-26 mol:protein length:233 DNA-3-methyladenine glycosidase
blastp_pdb 2h56_A 143 327 + 185 Gaps:1 78.97 233 33.70 1e-26 mol:protein length:233 DNA-3-methyladenine glycosidase
blastp_pdb 3s6i_D 133 325 + 193 Gaps:1 85.09 228 29.90 3e-25 mol:protein length:228 DNA-3-methyladenine glycosylase 1
blastp_pdb 3s6i_A 133 325 + 193 Gaps:1 85.09 228 29.90 3e-25 mol:protein length:228 DNA-3-methyladenine glycosylase 1
blastp_pdb 2yg9_B 135 333 + 199 Gaps:16 85.78 225 36.27 2e-24 mol:protein length:225 DNA-3-METHYLADENINE GLYCOSIDASE II PUTATIVE
blastp_pdb 2yg9_A 135 333 + 199 Gaps:16 85.78 225 36.27 2e-24 mol:protein length:225 DNA-3-METHYLADENINE GLYCOSIDASE II PUTATIVE
blastp_pdb 2yg8_B 135 333 + 199 Gaps:16 85.78 225 36.27 2e-24 mol:protein length:225 DNA-3-METHYLADENINE GLYCOSIDASE II PUTATIVE
blastp_pdb 2yg8_A 135 333 + 199 Gaps:16 85.78 225 36.27 2e-24 mol:protein length:225 DNA-3-METHYLADENINE GLYCOSIDASE II PUTATIVE
blastp_uniprot_sprot sp|Q92383|MAG1_SCHPO 133 325 + 193 Gaps:1 85.09 228 29.90 1e-24 DNA-3-methyladenine glycosylase 1 OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN mag1 PE 1 SV 1
blastp_uniprot_sprot sp|O31544|YFJP_BACSU 107 328 + 222 Gaps:15 77.00 287 30.32 9e-23 Putative DNA-3-methyladenine glycosylase YfjP OS Bacillus subtilis (strain 168) GN yfjP PE 3 SV 1
blastp_uniprot_sprot sp|O94468|MAG2_SCHPO 126 326 + 201 Gaps:4 96.24 213 26.83 1e-22 Probable DNA-3-methyladenine glycosylase 2 OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN mag2 PE 1 SV 1
blastp_uniprot_sprot sp|P22134|MAG_YEAST 134 327 + 194 Gaps:48 79.05 296 27.78 3e-15 DNA-3-methyladenine glycosylase OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN MAG1 PE 1 SV 1
blastp_uniprot_sprot sp|P37878|3MGA_BACSU 165 326 + 162 Gaps:9 56.44 303 26.32 2e-12 DNA-3-methyladenine glycosylase OS Bacillus subtilis (strain 168) GN alkA PE 1 SV 1
rpsblast_cdd gnl|CDD|30471 98 331 + 234 Gaps:13 86.67 285 33.20 4e-42 COG0122 AlkA 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication recombination and repair].
rpsblast_cdd gnl|CDD|201417 170 314 + 145 Gaps:12 99.31 144 28.67 2e-27 pfam00730 HhH-GPD HhH-GPD superfamily base excision DNA repair protein. This family contains a diverse range of structurally related DNA repair proteins. The superfamily is called the HhH-GPD family after its hallmark Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate. This includes endonuclease III EC:4.2.99.18 and MutY an A/G-specific adenine glycosylase both have a C terminal 4Fe-4S cluster. The family also includes 8-oxoguanine DNA glycosylases. The methyl-CPG binding protein MBD4 also contains a related domain that is a thymine DNA glycosylase. The family also includes DNA-3-methyladenine glycosylase II EC:3.2.2.21 and other members of the AlkA family.
rpsblast_cdd gnl|CDD|28938 165 327 + 163 Gaps:15 100.00 158 28.48 2e-21 cd00056 ENDO3c endonuclease III includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase) alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases.
rpsblast_cdd gnl|CDD|197751 175 328 + 154 Gaps:23 98.66 149 22.45 4e-11 smart00478 ENDO3c endonuclease III. includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase) alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases.
rpsblast_kog gnl|CDD|37129 105 341 + 237 Gaps:3 93.70 254 44.54 3e-79 KOG1918 KOG1918 KOG1918 3-methyladenine DNA glycosidase [Replication recombination and repair].

8 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Gene3D 164 275 112 G3DSA:1.10.340.30 "Reactome:REACT_216" none IPR011257
PANTHER 85 362 278 PTHR10242 none none none
SMART 173 328 156 SM00478 "Reactome:REACT_216" endonuclease III IPR003265
Pfam 170 314 145 PF00730 "Reactome:REACT_216" HhH-GPD superfamily base excision DNA repair protein IPR003265
Gene3D 276 328 53 G3DSA:1.10.1670.10 none none IPR023170
Coils 345 366 22 Coil none none none
PANTHER 85 362 278 PTHR10242:SF0 none none none
SUPERFAMILY 160 326 167 SSF48150 "Reactome:REACT_216" none IPR011257

0 Localization

9 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran1_2004_QTL1_peak_Bud_burst_A4 Qrob_Chr01 1 s_1AMVCC_444 s_1BE1VC_321 4 0 31 lod 3,2 7,4
Bourran2_2003_QTL8_peak_Bud_burst_A4 Qrob_Chr01 1 s_1AH7I_610 s_1BE1VC_321 4,6 0 28 lod 3,5 7,4
Bourran2_2007_QTL6_peak_Bud_burst_3P Qrob_Chr01 1 s_1BE1VC_321 s_1A5JRZ_890 5 0 25 lod 2,4 6
Bourran2_2014_nEpiBC_3P Qrob_Chr01 1 v_1588_550 s_1AZJRA_1600 30,48 9,48 43,98 lod 2,3642 6,3
Bourran2_2014_nLBD*_A4 Qrob_Chr08 8 v_12498_318 v_12364_308 34,91 16,12 53,62 lod 2,4961 5,2
Bourran2_2014_rEpiBC*_A4 Qrob_Chr08 8 v_12498_318 v_12364_308 35,77 14,11 55,31 lod 2,9413 6,2
Bourran2_2015_nEpiBC_3P Qrob_Chr12 12 s_1B73S5_217 v_7050_211 28,31 26,37 28,45 lod 4.5 11.6
Bourran2_2015_rEpiBC_3P Qrob_Chr08 8 s_A9TNV_543 v_11837_70 9,93 9,83 11,15 lod 3.3 7.3
Bourran2_2014_nSeqBC*_A4 Qrob_Chr01 1 s_1CFE4C_2114 s_1BDNCB_819 15,25 2 28,5 lod 2,9903 8,3

0 Targeting