Protein : Qrob_P0345470.2 Q. robur
Protein Identifier  ? Qrob_P0345470.2 Organism . Name  Quercus robur
Score  6.0 Score Type  egn
Protein Description  (M=1) KOG0403//KOG0946//KOG2005 - Neoplastic transformation suppressor Pdcd4/MA-3 contains MA3 domain [Signal transduction mechanisms]. // ER-Golgi vesicle-tethering protein p115 [Intracellular trafficking secretion and vesicular transport]. // 26S proteasome regulatory complex subunit RPN1/PSMD2 [Posttranslational modification protein turnover chaperones]. Gene Prediction Quality  validated
Protein length 

Sequence

Length: 796  
Kegg Orthology  K03028
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0 Synonyms

4 GO Terms

Identifier Name Description
GO:0005488 binding The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
GO:0030234 enzyme regulator activity Binds to and modulates the activity of an enzyme.
GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.
GO:0042176 regulation of protein catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.

33 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|pmum:103328445 450 641 + 192 Gaps:2 64.45 301 88.14 3e-108 26S proteasome non-ATPase regulatory subunit 2 homolog A-like
blastp_kegg lcl|cam:101498643 450 641 + 192 Gaps:2 21.90 886 89.18 6e-105 26S proteasome non-ATPase regulatory subunit 2 1A-like
blastp_kegg lcl|tcc:TCM_008190 450 641 + 192 Gaps:2 21.92 885 90.72 7e-105 26S proteasome regulatory subunit S2 1A isoform 1
blastp_kegg lcl|mtr:MTR_4g078780 450 641 + 192 Gaps:2 21.90 886 89.69 2e-104 26S proteasome non-ATPase regulatory subunit
blastp_kegg lcl|csv:101206940 450 641 + 192 Gaps:2 21.65 896 87.63 6e-104 26S proteasome non-ATPase regulatory subunit 2 1A-like
blastp_kegg lcl|cmo:103495645 450 641 + 192 Gaps:2 21.65 896 87.63 1e-103 26S proteasome non-ATPase regulatory subunit 2 homolog A
blastp_kegg lcl|vvi:100255701 450 641 + 192 Gaps:2 21.80 890 88.66 2e-103 26S proteasome regulatory subunit N1-like
blastp_kegg lcl|mdm:103444431 450 641 + 192 Gaps:2 21.70 894 88.14 2e-102 26S proteasome non-ATPase regulatory subunit 2 homolog A
blastp_kegg lcl|gmx:100777078 450 641 + 192 Gaps:2 21.92 885 88.14 9e-102 26S proteasome non-ATPase regulatory subunit 2 homolog A-like
blastp_kegg lcl|fve:101302279 452 642 + 191 Gaps:2 21.64 892 86.53 2e-101 26S proteasome non-ATPase regulatory subunit 2 1A-like
blastp_pdb 2w3c_A 315 382 + 68 none 11.79 577 47.06 5e-09 mol:protein length:577 GENERAL VESICULAR TRANSPORT FACTOR P115
blastp_pdb 3grl_A 315 382 + 68 none 10.45 651 47.06 5e-09 mol:protein length:651 General vesicular transport factor p115
blastp_pdb 3gq2_B 315 382 + 68 none 10.45 651 47.06 5e-09 mol:protein length:651 General vesicular transport factor p115
blastp_pdb 3gq2_A 315 382 + 68 none 10.45 651 47.06 5e-09 mol:protein length:651 General vesicular transport factor p115
blastp_pdb 3eiq_C 670 794 + 125 Gaps:2 34.92 358 30.40 7e-06 mol:protein length:358 Programmed cell death protein 4
blastp_uniprot_sprot sp|Q9SIV2|PSD2A_ARATH 450 641 + 192 Gaps:2 21.77 891 82.47 1e-96 26S proteasome non-ATPase regulatory subunit 2 homolog A OS Arabidopsis thaliana GN RPN1A PE 1 SV 2
blastp_uniprot_sprot sp|Q6XJG8|PSD2B_ARATH 450 641 + 192 Gaps:2 21.77 891 78.35 8e-90 26S proteasome non-ATPase regulatory subunit 2 homolog B OS Arabidopsis thaliana GN RPN1B PE 1 SV 1
blastp_uniprot_sprot sp|Q13200|PSMD2_HUMAN 450 638 + 189 Gaps:5 20.93 908 54.74 1e-52 26S proteasome non-ATPase regulatory subunit 2 OS Homo sapiens GN PSMD2 PE 1 SV 3
blastp_uniprot_sprot sp|Q5R9I6|PSMD2_PONAB 450 638 + 189 Gaps:5 20.93 908 54.21 2e-52 26S proteasome non-ATPase regulatory subunit 2 OS Pongo abelii GN PSMD2 PE 2 SV 1
blastp_uniprot_sprot sp|P56701|PSMD2_BOVIN 450 638 + 189 Gaps:5 20.93 908 54.21 4e-52 26S proteasome non-ATPase regulatory subunit 2 OS Bos taurus GN PSMD2 PE 1 SV 2
blastp_uniprot_sprot sp|Q4FZT9|PSMD2_RAT 450 638 + 189 Gaps:5 20.93 908 54.21 1e-51 26S proteasome non-ATPase regulatory subunit 2 OS Rattus norvegicus GN Psmd2 PE 2 SV 1
blastp_uniprot_sprot sp|Q8VDM4|PSMD2_MOUSE 450 638 + 189 Gaps:5 20.93 908 54.21 1e-51 26S proteasome non-ATPase regulatory subunit 2 OS Mus musculus GN Psmd2 PE 1 SV 1
blastp_uniprot_sprot sp|P87048|RPN1_SCHPO 450 642 + 193 Gaps:2 21.89 891 52.31 1e-48 26S proteasome regulatory subunit rpn1 OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN rpn1 PE 1 SV 2
blastp_uniprot_sprot sp|Q54BC6|PSMD2_DICDI 450 636 + 187 Gaps:3 21.05 893 53.19 4e-48 26S proteasome non-ATPase regulatory subunit 2 OS Dictyostelium discoideum GN psmD2 PE 1 SV 1
blastp_uniprot_sprot sp|B0F9L4|GOGC6_ARATH 331 449 + 119 Gaps:17 14.88 914 69.85 6e-47 Golgin candidate 6 OS Arabidopsis thaliana GN GC6 PE 1 SV 2
rpsblast_cdd gnl|CDD|34713 450 638 + 189 Gaps:3 21.79 881 47.40 2e-51 COG5110 RPN1 26S proteasome regulatory complex component [Posttranslational modification protein turnover chaperones].
rpsblast_cdd gnl|CDD|111714 714 794 + 81 Gaps:1 72.57 113 35.37 1e-14 pfam02847 MA3 MA3 domain. Domain in DAP-5 eIF4G MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.
rpsblast_cdd gnl|CDD|128817 714 794 + 81 Gaps:1 72.57 113 35.37 3e-13 smart00544 MA3 Domain in DAP-5 eIF4G MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press.
rpsblast_cdd gnl|CDD|165506 130 333 + 204 Gaps:14 6.60 3151 19.23 2e-08 PHA03247 PHA03247 large tegument protein UL36 Provisional.
rpsblast_cdd gnl|CDD|146000 130 305 + 176 Gaps:13 19.31 979 21.69 6e-08 pfam03154 Atrophin-1 Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1 that is thought to confer toxicity to the protein possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.

12 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Pfam 714 793 80 PF02847 none MA3 domain IPR003891
Phobius 8 15 8 SIGNAL_PEPTIDE_H_REGION none Hydrophobic region of a signal peptide. none
Phobius 21 795 775 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Gene3D 712 793 82 G3DSA:1.25.40.180 none none IPR016021
PANTHER 431 639 209 PTHR10943 none none none
SUPERFAMILY 710 793 84 SSF48371 none none IPR016024
Phobius 1 7 7 SIGNAL_PEPTIDE_N_REGION none N-terminal region of a signal peptide. none
Phobius 16 20 5 SIGNAL_PEPTIDE_C_REGION none C-terminal region of a signal peptide. none
PANTHER 431 639 209 PTHR10943:SF1 none none IPR016643
ProSiteProfiles 713 795 83 PS51366 none MI domain profile. IPR003891
SMART 714 794 81 SM00544 none Domain in DAP-5, eIF4G, MA-3 and other proteins. IPR003891
Phobius 1 20 20 SIGNAL_PEPTIDE none Signal peptide region none

0 Localization

2 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran2_2015_nEpis_3P Qrob_Chr12 12 s_1AOES6_1466 s_1B0DDG_1094 28,97 28,55 30,1 lod 3.6 8.4
Bourran2_2015_nP_3P Qrob_Chr12 12 v_10140_295 v_838_303 16 14,69 18,01 lod 5.1 13.7

0 Targeting