Blast Analysis : gnl|CDD|146000

Analysis  rpsblast_cdd Start  130
End  305 Strand  +
Length  176 Note  Gaps:13
Hit Coverage  19.31 Hit Length  979
Hit Pident  21.69 E Val  6e-08
Hit Description  pfam03154 Atrophin-1 Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1 that is thought to confer toxicity to the protein possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity. Hit Pcons  10.58
Name  Qrob_P0345470.2
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1 Protein

Protein Identifier
Organism . Name 		Score Score Type Protein Description Alias (in v1) Code Enzyme Gene Prediction Quality
Qrob_P0345470.2 Quercus robur 6.0 egn (M=1) KOG0403//KOG0946//KOG2005 - Neoplastic transformation suppressor Pdcd4/MA-3 contains MA3 domain [Signal transduction mechanisms]. // ER-Golgi vesicle-tethering protein p115 [Intracellular trafficking secretion and vesicular transport]. // 26S proteasome regulatory complex subunit RPN1/PSMD2 [Posttranslational modification protein turnover chaperones].     validated