Protein : Qrob_P0314110.2 Q. robur
Protein Identifier  ? Qrob_P0314110.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=1) 1.13.11.54 - Acireductone dioxygenase (Fe(2+)-requiring). Code Enzyme  EC:1.13.11.54
Gene Prediction Quality  validated Protein length 

Sequence

Length: 181  
Kegg Orthology  K08967
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0 Synonyms

4 GO Terms

Identifier Name Description
GO:0016491 oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
GO:0055114 oxidation-reduction process A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
GO:0019509 L-methionine biosynthetic process from methylthioadenosine The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine.
GO:0010309 acireductone dioxygenase [iron(II)-requiring] activity Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O(2) = 4-methylthio-2-oxobutanoate + formate + H(+).

26 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|pper:PRUPE_ppa011986mg 1 180 + 180 none 96.26 187 86.67 7e-114 hypothetical protein
blastp_kegg lcl|pxb:103961142 1 180 + 180 none 97.30 185 85.56 3e-113 1 2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1-like
blastp_kegg lcl|pmum:103323991 1 180 + 180 none 95.74 188 86.11 5e-113 1 2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1
blastp_kegg lcl|fve:101296477 1 180 + 180 none 96.26 187 86.11 1e-112 1 2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1-like
blastp_kegg lcl|pxb:103964742 1 180 + 180 none 97.30 185 85.00 2e-112 1 2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1-like
blastp_kegg lcl|cic:CICLE_v10006993mg 1 180 + 180 none 82.95 217 84.44 2e-112 hypothetical protein
blastp_kegg lcl|cit:102624829 1 180 + 180 none 96.26 187 84.44 8e-112 1 2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1-like
blastp_kegg lcl|sot:102599891 1 180 + 180 none 96.26 187 83.89 1e-111 1 2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1-like
blastp_kegg lcl|rcu:RCOM_0911100 1 180 + 180 none 96.26 187 85.00 9e-111 acireductone dioxygenase putative
blastp_kegg lcl|sly:101255136 1 180 + 180 none 96.26 187 82.22 5e-110 1 2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1-like
blastp_pdb 1vr3_A 1 169 + 169 none 88.48 191 61.54 3e-72 mol:protein length:191 Acireductone dioxygenase
blastp_pdb 2hji_A 53 154 + 102 Gaps:16 61.45 179 29.09 1e-06 mol:protein length:179 E-2/E-2' protein
blastp_pdb 1zrr_A 53 154 + 102 Gaps:16 61.45 179 29.09 1e-06 mol:protein length:179 E-2/E-2' protein
blastp_uniprot_sprot sp|D7T737|MTND1_VITVI 1 180 + 180 none 95.74 188 83.33 6e-112 1 2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1 OS Vitis vinifera GN VIT_05s0020g04070 PE 3 SV 1
blastp_uniprot_sprot sp|Q8H185|MTND4_ARATH 1 180 + 180 none 96.26 187 79.44 1e-104 1 2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 4 OS Arabidopsis thaliana GN ARD4 PE 2 SV 1
blastp_uniprot_sprot sp|F6HDT7|MTND2_VITVI 1 172 + 172 none 86.43 199 66.86 2e-88 1 2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 2 OS Vitis vinifera GN VIT_05s0020g04080 PE 3 SV 1
blastp_uniprot_sprot sp|C5X1F5|MTND1_SORBI 1 179 + 179 none 99.44 180 65.36 2e-88 1 2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1 OS Sorghum bicolor GN Sb01g021500 PE 3 SV 2
blastp_uniprot_sprot sp|Q7XEJ5|MTND4_ORYSJ 15 180 + 166 none 90.22 184 70.48 2e-87 1 2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 4 OS Oryza sativa subsp. japonica GN ARD4 PE 2 SV 1
blastp_uniprot_sprot sp|Q10RE5|MTND2_ORYSJ 1 174 + 174 none 87.88 198 66.09 3e-87 1 2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 2 OS Oryza sativa subsp. japonica GN ARD2 PE 2 SV 1
blastp_uniprot_sprot sp|A2XCT8|MTND2_ORYSI 1 174 + 174 none 87.88 198 66.09 3e-87 1 2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 2 OS Oryza sativa subsp. indica GN ARD2 PE 2 SV 2
blastp_uniprot_sprot sp|C5WWY0|MTND2_SORBI 1 174 + 174 none 96.13 181 66.09 5e-87 1 2-dihydroxy-3-keto-5-methylthiopentene dioxygenase homolog 2 OS Sorghum bicolor GN Sb01g046360 PE 3 SV 1
blastp_uniprot_sprot sp|O48707|MTND1_ARATH 1 174 + 174 none 87.44 199 65.52 4e-85 1 2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1 OS Arabidopsis thaliana GN ARD1 PE 2 SV 1
blastp_uniprot_sprot sp|A1L4T4|MTND1_ORYSJ 1 174 + 174 none 87.44 199 64.94 1e-84 1 2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1 OS Oryza sativa subsp. japonica GN ARD1 PE 2 SV 1
rpsblast_cdd gnl|CDD|111920 2 151 + 150 Gaps:1 96.18 157 56.95 2e-53 pfam03079 ARD ARD/ARD' family. The two acireductone dioxygenase enzymes (ARD and ARD' previously known as E-2 and E-2') from Klebsiella pneumoniae share the same amino acid sequence but bind different metal ions: ARD binds Ni2+ ARD' binds Fe2+. ARD and ARD' can be experimentally interconverted by removal of the bound metal ion and reconstitution with the appropriate metal ion. The two enzymes share the same substrate 1 2-dihydroxy-3-keto-5-(methylthio)pentene but yield different products. ARD' yields the alpha-keto precursor of methionine (and formate) thus forming part of the ubiquitous methionine salvage pathway that converts 5'-methylthioadenosine (MTA) to methionine. This pathway is responsible for the tight control of the concentration of MTA which is a powerful inhibitor of polyamine biosynthesis and transmethylation reactions. ARD yields methylthiopropanoate carbon monoxide and formate and thus prevents the conversion of MTA to methionine. The role of the ARD catalyzed reaction is unclear: methylthiopropanoate is cytotoxic and carbon monoxide can activate guanylyl cyclase leading to increased intracellular cGMP levels. This family also contains other members whose functions are not well characterized.
rpsblast_cdd gnl|CDD|31976 2 169 + 168 Gaps:7 92.27 181 31.74 5e-29 COG1791 COG1791 Uncharacterized conserved protein contains double-stranded beta-helix domain [Function unknown].
rpsblast_kog gnl|CDD|37318 2 172 + 171 none 95.53 179 62.57 3e-68 KOG2107 KOG2107 KOG2107 Uncharacterized conserved protein contains double-stranded beta-helix domain [Function unknown].

6 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
PANTHER 1 178 178 PTHR23418:SF0 none none none
Gene3D 1 170 170 G3DSA:2.60.120.10 none none IPR014710
Pfam 1 151 151 PF03079 "KEGG:00270+1.13.11.54","MetaCyc:PWY-4361","UniPathway:UPA00904" ARD/ARD' family IPR004313
SUPERFAMILY 1 169 169 SSF51182 none none IPR011051
PANTHER 1 178 178 PTHR23418 "KEGG:00270+1.13.11.54","MetaCyc:PWY-4361","UniPathway:UPA00904";signature_desc=ACIREDUCTONE DIOXYGENASE none IPR004313
Hamap 1 164 164 MF_03154 "KEGG:00270+1.13.11.54","MetaCyc:PWY-4361","UniPathway:UPA00904" 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase [ADI1]. IPR027496

0 Localization

8 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran2_2014_nLBD*_3P Qrob_Chr08 8 v_5216_549 v_11837_70 12,25 0 35,55 lod 2,5951 6
Bourran2_2014_nP*_3P Qrob_Chr08 8 v_5216_549 v_11837_70 12,19 0 31,97 lod 2,8472 6
Bourran2_2002_QTL11_peak_Bud_burst_A4 Qrob_Chr06 6 s_1C41PA_791 s_1AM1AV_1141 19,17 0 34,57 lod 2,3 2,9
Bourran2_2014_nEpis*_3P Qrob_Chr08 8 s_1DA4QW_688 s_1DNI7D_820 17,96 0 37,75 lod 2,9745 7,5
Bourran2_2014_nPriLBD*_3P Qrob_Chr11 11 v_12066_307 s_1B15GJ_447 3,37 0,57 16,17 lod 3,4299 6,9
Champenoux_2015_nEpis_3P Qrob_Chr11 11 s_1DG9PM_867 s_1BZ083_1312 26,53 25,47 27,72 lod 4.4 8.9
Champenoux_2015_nP_3P Qrob_Chr06 6 s_1A386O_228 s_1AYZFS_603 27,03 26,47 27,34 lod 2.8 7.2
Bourran2_2014_nPriBD*_3P Qrob_Chr06 6 s_1B6WLL_980 v_10064_133 11,49 0 31,52 lod 4,1208 9,1

0 Targeting