Protein : Qrob_P0289640.2 Q. robur
Protein Identifier  ? Qrob_P0289640.2 Organism . Name  Quercus robur
Score  88.0 Score Type  egn
Protein Description  (M=2) K02328 - DNA polymerase delta subunit 2 Code Enzyme  EC:2.7.7.7
Gene Prediction Quality  validated Protein length 

Sequence

Length: 226  
Kegg Orthology  K02328
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0 Synonyms

3 GO Terms

Identifier Name Description
GO:0003677 DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GO:0006260 DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
GO:0003887 DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.

28 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|vvi:100241865 5 225 + 221 Gaps:4 51.25 439 81.33 8e-132 DNA polymerase delta small subunit-like
blastp_kegg lcl|pmum:103339416 5 225 + 221 Gaps:4 51.02 441 80.44 1e-129 DNA polymerase delta small subunit
blastp_kegg lcl|tcc:TCM_024908 5 225 + 221 Gaps:4 50.90 442 79.11 3e-129 DNA polymerase delta small subunit isoform 1
blastp_kegg lcl|pper:PRUPE_ppa005894mg 5 225 + 221 Gaps:4 51.37 438 80.00 6e-129 hypothetical protein
blastp_kegg lcl|pxb:103958951 5 225 + 221 Gaps:4 50.90 442 79.11 5e-127 DNA polymerase delta small subunit
blastp_kegg lcl|mdm:103421761 5 225 + 221 Gaps:4 58.29 386 78.22 1e-126 DNA polymerase delta small subunit-like
blastp_kegg lcl|mdm:103411519 5 225 + 221 Gaps:4 55.42 406 78.22 9e-126 DNA polymerase delta small subunit-like
blastp_kegg lcl|mdm:103454327 5 225 + 221 Gaps:4 74.50 302 77.33 1e-125 DNA polymerase delta small subunit
blastp_kegg lcl|mdm:103429235 5 225 + 221 Gaps:4 50.90 442 78.22 2e-125 DNA polymerase delta small subunit-like
blastp_kegg lcl|cmo:103486765 5 224 + 220 Gaps:4 50.91 440 77.23 8e-125 DNA polymerase delta small subunit
blastp_pdb 3e0j_G 23 219 + 197 none 41.39 476 48.22 6e-64 mol:protein length:476 DNA polymerase subunit delta-2
blastp_pdb 3e0j_E 23 219 + 197 none 41.39 476 48.22 6e-64 mol:protein length:476 DNA polymerase subunit delta-2
blastp_pdb 3e0j_C 23 219 + 197 none 41.39 476 48.22 6e-64 mol:protein length:476 DNA polymerase subunit delta-2
blastp_pdb 3e0j_A 23 219 + 197 none 41.39 476 48.22 6e-64 mol:protein length:476 DNA polymerase subunit delta-2
blastp_uniprot_sprot sp|O48520|DPOD2_ARATH 5 224 + 220 Gaps:4 50.91 440 75.89 5e-121 DNA polymerase delta small subunit OS Arabidopsis thaliana GN POLD2 PE 2 SV 2
blastp_uniprot_sprot sp|Q9LRE5|DPOD2_ORYSJ 6 225 + 220 Gaps:4 52.21 429 68.75 4e-113 DNA polymerase delta small subunit OS Oryza sativa subsp. japonica GN POLD2 PE 2 SV 1
blastp_uniprot_sprot sp|O93610|DPOD2_XENLA 23 219 + 197 none 42.55 463 48.73 2e-64 DNA polymerase delta subunit 2 OS Xenopus laevis GN pold2 PE 2 SV 1
blastp_uniprot_sprot sp|O35654|DPOD2_MOUSE 23 220 + 198 none 42.22 469 47.98 3e-64 DNA polymerase delta subunit 2 OS Mus musculus GN Pold2 PE 2 SV 2
blastp_uniprot_sprot sp|P49005|DPOD2_HUMAN 23 219 + 197 none 42.00 469 48.22 2e-63 DNA polymerase delta subunit 2 OS Homo sapiens GN POLD2 PE 1 SV 1
blastp_uniprot_sprot sp|Q6AXY4|DPOD2_RAT 23 220 + 198 none 42.22 469 47.98 2e-63 DNA polymerase delta subunit 2 OS Rattus norvegicus GN Pold2 PE 1 SV 1
blastp_uniprot_sprot sp|P49004|DPOD2_BOVIN 23 219 + 197 none 42.00 469 48.22 3e-63 DNA polymerase delta subunit 2 OS Bos taurus GN POLD2 PE 1 SV 2
blastp_uniprot_sprot sp|Q9W088|DPOD2_DROME 41 222 + 182 none 42.23 431 43.96 4e-55 DNA polymerase delta small subunit OS Drosophila melanogaster GN CG12018 PE 2 SV 1
blastp_uniprot_sprot sp|P87324|DPOD2_SCHPO 42 219 + 178 Gaps:3 38.74 462 40.22 6e-39 DNA polymerase subunit delta-2 OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN cdc1 PE 1 SV 1
blastp_uniprot_sprot sp|P46957|DPOD2_YEAST 30 219 + 190 Gaps:31 44.97 487 34.70 1e-37 DNA polymerase delta small subunit OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN POL31 PE 1 SV 1
rpsblast_cdd gnl|CDD|163630 28 219 + 192 none 74.71 257 58.33 5e-89 cd07387 MPP_PolD2_C PolD2 (DNA polymerase delta subunit 2) C-terminal domain. PolD2 (DNA polymerase delta subunit 2) is an auxiliary subunit of the eukaryotic DNA polymerase delta (PolD) complex thought to play a regulatory role and to serve as a scaffold for PolD assembly by interacting simultaneously with all of the other three subunits. PolD2 is catalytically inactive and lacks the active site residues required for phosphoesterase activity in other members of this superfamily. PolD2 is also involved in the recruitment of several proteins regulating DNA metabolism including p21 PDIP1 PDIP38 PDIP46 and WRN. Human PolD consists of four subunits: p125 (PolD1) p50 (PolD2) p66(PolD3) and p12(PolD4). PolD is one of three major replicases in eukaryotes. PolD also plays an essential role in translesion DNA synthesis homologous recombination and DNA repair. Within the PolD complex PolD2 tightly associates with PolD3. PolD2 belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse but share a conserved domain with an active site consisting of two metal ions (usually manganese iron or zinc) coordinated with octahedral geometry by a cage of histidine aspartate and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases Dbr1-like RNA lariat debranching enzymes YfcE-like phosphodiesterases purple acid phosphatases (PAPs) YbbF-like UDP-2 3-diacylglucosamine hydrolases and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.
rpsblast_cdd gnl|CDD|202861 23 177 + 155 Gaps:6 85.19 189 36.02 1e-37 pfam04042 DNA_pol_E_B DNA polymerase alpha/epsilon subunit B. This family contains a number of DNA polymerase subunits. The B subunit of the DNA polymerase alpha plays an essential role at the initial stage of DNA replication in S. cerevisiae and is phosphorylated in a cell cycle-dependent manner. DNA polymerase epsilon is essential for cell viability and chromosomal DNA replication in budding yeast. In addition DNA polymerase epsilon may be involved in DNA repair and cell-cycle checkpoint control. The enzyme consists of at least four subunits in mammalian cells as well as in yeast. The largest subunit of DNA polymerase epsilon is responsible for polymerase epsilon is responsible for polymerase activity. In mouse the DNA polymerase epsilon subunit B is the second largest subunit of the DNA polymerase. A part of the N-terminal was found to be responsible for the interaction with SAP18. Experimental evidence suggests that this subunit may recruit histone deacetylase to the replication fork to modify the chromatin structure.
rpsblast_cdd gnl|CDD|31502 41 222 + 182 Gaps:13 37.63 481 30.39 2e-26 COG1311 HYS2 Archaeal DNA polymerase II small subunit/DNA polymerase delta subunit B [DNA replication recombination and repair].
rpsblast_kog gnl|CDD|37943 30 219 + 190 Gaps:2 43.68 435 55.26 7e-73 KOG2732 KOG2732 KOG2732 DNA polymerase delta regulatory subunit 55 [Replication recombination and repair].

3 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Pfam 22 177 156 PF04042 "Reactome:REACT_152","Reactome:REACT_22172","Reactome:REACT_383" DNA polymerase alpha/epsilon subunit B IPR007185
PANTHER 23 223 201 PTHR10416:SF0 none none none
PANTHER 23 223 201 PTHR10416 "KEGG:00230+2.7.7.7","KEGG:00240+2.7.7.7";signature_desc=DNA POLYMERASE DELTA SUBUNIT 2 none IPR024826

0 Localization

10 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran2_2014_nLBD*_A4 Qrob_Chr08 8 v_12498_318 v_12364_308 34,91 16,12 53,62 lod 2,4961 5,2
Bourran2_2014_nPriLBD_3P Qrob_Chr08 8 v_5216_549 v_11837_70 12,36 0 30,43 lod 2,5806 5,1
Bourran2_2014_nSecLBD_A4 Qrob_Chr07 7 v_8327_222 s_1A4WGY_363 16,04 0 44,69 lod 2,6373 6,5
Bourran2_2014_nP_A4 Qrob_Chr11 11 s_1B58GB_1413 s_1A5BYY_1671 11,15 0 42,38 lod 1,8913 4,5
Bourran2_2015_nSeqBC_3P Qrob_Chr11 11 s_1DG9PM_867 s_1BZ083_1312 26,06 25,47 27,72 lod 3.6 7.1
Bourran2_2014_nP_3P Qrob_Chr11 11 v_11486_194 s_1AT3E_2335 7,9 0,09 30,09 lod 2,3636 5
Bourran2_2015_nEpis_A4 Qrob_Chr09 9 v_15847_485 v_8329_369 34,94 34,88 37,45 lod 3.1 7
Bourran2_2015_nEpiBC_A4 Qrob_Chr07 7 s_1DP9TW_798 v_8128_173 22,61 22,14 22,73 lod 3.1 8.5
Bourran2_2014_nEpiBC_A4 Qrob_Chr07 7 s_2FI9D9_500 s_1AXDMJ_325 12,26 0 34,9 lod 2,2306 6,1
Bourran2_2014_nPriBD_3P Qrob_Chr11 11 v_11486_194 s_1AT3E_2335 5,54 0,4 20,6 lod 2,6345 5,9

0 Targeting