| Analysis | rpsblast_cdd | Start | 28 |
| End | 219 | Strand | + |
| Length | 192 | Note | none |
| Hit Coverage | 74.71 | Hit Length | 257 |
| Hit Pident | 58.33 | E Val | 5e-89 |
| Hit Description | cd07387 MPP_PolD2_C PolD2 (DNA polymerase delta subunit 2) C-terminal domain. PolD2 (DNA polymerase delta subunit 2) is an auxiliary subunit of the eukaryotic DNA polymerase delta (PolD) complex thought to play a regulatory role and to serve as a scaffold for PolD assembly by interacting simultaneously with all of the other three subunits. PolD2 is catalytically inactive and lacks the active site residues required for phosphoesterase activity in other members of this superfamily. PolD2 is also involved in the recruitment of several proteins regulating DNA metabolism including p21 PDIP1 PDIP38 PDIP46 and WRN. Human PolD consists of four subunits: p125 (PolD1) p50 (PolD2) p66(PolD3) and p12(PolD4). PolD is one of three major replicases in eukaryotes. PolD also plays an essential role in translesion DNA synthesis homologous recombination and DNA repair. Within the PolD complex PolD2 tightly associates with PolD3. PolD2 belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse but share a conserved domain with an active site consisting of two metal ions (usually manganese iron or zinc) coordinated with octahedral geometry by a cage of histidine aspartate and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases Dbr1-like RNA lariat debranching enzymes YfcE-like phosphodiesterases purple acid phosphatases (PAPs) YbbF-like UDP-2 3-diacylglucosamine hydrolases and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination. | Hit Pcons | 16.67 |
| Name | Qrob_P0289640.2 |
| Protein Identifier |
Organism . Name |
Score | Score Type | Protein Description | Alias (in v1) | Code Enzyme | Gene Prediction Quality |
|---|---|---|---|---|---|---|---|
| Qrob_P0289640.2 | Quercus robur | 88.0 | egn | (M=2) K02328 - DNA polymerase delta subunit 2 | EC:2.7.7.7 | validated |
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