Protein : Qrob_P0277930.2 Q. robur

Protein Identifier  ? Qrob_P0277930.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=2) 1.14.99.7 - Transferred entry: 1.14.13.132. Code Enzyme  EC:1.14.99.7
Gene Prediction Quality  validated Protein length 

Sequence

Length: 525  
Kegg Orthology  K00511

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0 Synonyms

5 GO Terms

Identifier Name Description
GO:0016491 oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
GO:0055114 oxidation-reduction process A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
GO:0050660 flavin adenine dinucleotide binding Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
GO:0016021 integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
GO:0004506 squalene monooxygenase activity Catalysis of the reaction: H(+) + NADPH + O(2) + squalene = (S)-2,3-epoxysqualene + H(2)O + NADP(+).

31 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|tcc:TCM_006347 1 524 + 524 Gaps:11 100.00 529 81.10 0.0 Squalene monooxygenase
blastp_kegg lcl|csv:101204949 9 523 + 515 Gaps:4 97.90 524 81.29 0.0 squalene monooxygenase-like
blastp_kegg lcl|gmx:100800329 1 524 + 524 Gaps:3 97.94 534 79.35 0.0 squalene monooxygenase-like
blastp_kegg lcl|vvi:100265235 1 522 + 522 Gaps:7 99.81 524 78.97 0.0 squalene monooxygenase-like
blastp_kegg lcl|cmo:103493632 9 523 + 515 Gaps:4 97.90 524 80.70 0.0 squalene monooxygenase-like
blastp_kegg lcl|tcc:TCM_034641 7 524 + 518 Gaps:4 99.04 523 79.73 0.0 Squalene monooxygenase isoform 1
blastp_kegg lcl|pmum:103334961 1 524 + 524 Gaps:5 100.00 523 79.54 0.0 squalene monooxygenase-like
blastp_kegg lcl|pper:PRUPE_ppa004197mg 1 524 + 524 Gaps:5 100.00 523 78.97 0.0 hypothetical protein
blastp_kegg lcl|tcc:TCM_006346 1 524 + 524 Gaps:5 100.00 525 79.24 0.0 Squalene monooxygenase isoform 1
blastp_kegg lcl|gmx:100795522 7 523 + 517 Gaps:6 98.67 526 80.35 0.0 squalene monooxygenase-like
blastp_pdb 2x3n_A 61 364 + 304 Gaps:58 76.19 399 25.99 4e-09 mol:protein length:399 PROBABLE FAD-DEPENDENT MONOOXYGENASE
blastp_uniprot_sprot sp|O48651|ERG1_PANGI 59 524 + 466 none 86.46 539 83.48 0.0 Squalene monooxygenase OS Panax ginseng PE 2 SV 1
blastp_uniprot_sprot sp|Q9SM02|ERG14_ARATH 38 522 + 485 Gaps:6 92.47 531 76.99 0.0 Squalene epoxidase 1 OS Arabidopsis thaliana GN SQE1 PE 1 SV 1
blastp_uniprot_sprot sp|Q8VYH2|ERG16_ARATH 6 520 + 515 Gaps:12 96.19 525 75.05 0.0 Squalene epoxidase 3 OS Arabidopsis thaliana GN SQE3 PE 1 SV 1
blastp_uniprot_sprot sp|O81000|ERG15_ARATH 12 522 + 511 Gaps:7 86.84 585 72.83 0.0 Squalene epoxidase 2 mitochondrial OS Arabidopsis thaliana GN SQE2 PE 1 SV 1
blastp_uniprot_sprot sp|O65404|ERG11_ARATH 9 520 + 512 Gaps:23 97.87 516 51.68 4e-179 Squalene epoxidase 5 OS Arabidopsis thaliana GN SQE5 PE 2 SV 2
blastp_uniprot_sprot sp|O65402|ERG12_ARATH 53 520 + 468 Gaps:4 91.30 517 50.64 8e-169 Squalene epoxidase 6 OS Arabidopsis thaliana GN SQE6 PE 2 SV 1
blastp_uniprot_sprot sp|O65727|ERG11_BRANA 10 520 + 511 Gaps:23 97.23 506 51.22 2e-167 Squalene monooxygenase 1 1 OS Brassica napus GN SQP1 1 PE 2 SV 1
blastp_uniprot_sprot sp|O65726|ERG12_BRANA 52 520 + 469 Gaps:2 90.93 518 48.62 2e-166 Squalene monooxygenase 1 2 OS Brassica napus GN SQP1 2 PE 2 SV 1
blastp_uniprot_sprot sp|O65403|ERG13_ARATH 1 519 + 519 Gaps:21 98.45 516 46.46 2e-159 Squalene epoxidase 4 OS Arabidopsis thaliana GN SQE4 PE 2 SV 1
blastp_uniprot_sprot sp|Q14534|ERG1_HUMAN 43 503 + 461 Gaps:14 80.31 574 45.34 5e-125 Squalene monooxygenase OS Homo sapiens GN SQLE PE 1 SV 3
rpsblast_cdd gnl|CDD|178566 10 520 + 511 Gaps:29 98.05 514 50.99 1e-161 PLN02985 PLN02985 squalene monooxygenase.
rpsblast_cdd gnl|CDD|192047 210 483 + 274 Gaps:4 100.00 276 60.51 1e-135 pfam08491 SE Squalene epoxidase. This domain is found in squalene epoxidase (SE) and related proteins which are found in taxonomically diverse groups of eukaryotes and also in bacteria. SE was first cloned from Saccharomyces cerevisiae where it was named ERG1. It contains a putative FAD binding site and is a key enzyme in the sterol biosynthetic pathway. Putative transmembrane regions are found to the protein's C-terminus.
rpsblast_cdd gnl|CDD|185578 61 506 + 446 Gaps:78 87.48 567 39.11 1e-122 PTZ00367 PTZ00367 squalene epoxidase Provisional.
rpsblast_cdd gnl|CDD|30999 58 437 + 380 Gaps:14 96.12 387 23.39 1e-38 COG0654 UbiH 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion].
rpsblast_cdd gnl|CDD|30989 61 393 + 333 Gaps:31 80.30 396 24.53 7e-19 COG0644 FixC Dehydrogenases (flavoproteins) [Energy production and conversion].
rpsblast_cdd gnl|CDD|180451 54 227 + 174 Gaps:28 42.75 407 34.48 2e-18 PRK06185 PRK06185 hypothetical protein Provisional.
rpsblast_cdd gnl|CDD|136171 61 410 + 350 Gaps:44 89.69 388 29.89 6e-17 PRK07045 PRK07045 putative monooxygenase Reviewed.
rpsblast_cdd gnl|CDD|200151 61 363 + 303 Gaps:45 96.27 295 22.54 4e-09 TIGR02032 GG-red-SF geranylgeranyl reductase family. This HMM represents a subfamily which includes geranylgeranyl reductases involved in chlorophyll and bacteriochlorophyll biosynthesis as well as other related enzymes which may also act on geranylgeranyl groups or related substrates.
rpsblast_kog gnl|CDD|36512 10 522 + 513 Gaps:11 99.02 509 65.87 0.0 KOG1298 KOG1298 KOG1298 Squalene monooxygenase [Lipid transport and metabolism].

18 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Pfam 211 483 273 PF08491 "KEGG:00100+1.14.13.132","KEGG:00909+1.14.13.132","MetaCyc:PWY-5670","MetaCyc:PWY-6098","UniPathway:UPA00767" Squalene epoxidase IPR013698
SUPERFAMILY 325 435 111 SSF51905 none none none
SUPERFAMILY 60 231 172 SSF51905 none none none
Phobius 482 500 19 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 455 476 22 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Gene3D 58 234 177 G3DSA:3.50.50.60 none none none
Gene3D 336 369 34 G3DSA:3.50.50.60 none none none
PANTHER 23 523 501 PTHR10835 none none none
Phobius 25 454 430 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Pfam 61 91 31 PF01266 none FAD dependent oxidoreductase IPR006076
PRINTS 61 83 23 PR00420 none Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature none
PRINTS 353 369 17 PR00420 none Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature none
PRINTS 338 353 16 PR00420 none Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature none
PRINTS 210 225 16 PR00420 none Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature none
Phobius 6 24 19 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 1 5 5 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 477 481 5 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 501 524 24 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none

4 Localization

Analysis Start End Length
TMHMM 62 79 17
TMHMM 483 500 17
TMHMM 5 24 19
TMHMM 454 476 22

0 Qtllist

1 Targeting

Analysis Start End Length Location Reliability Signal Peptide Cut Off Mitochondrion Cut Off Network Signal Peptide Length
TargetP 1 26   Secretory pathway 2 0.940 0.026 NON-PLANT 26