Protein : Qrob_P0200770.2 Q. robur
Protein Identifier  ? Qrob_P0200770.2 Organism . Name  Quercus robur
Protein Description  (M=1) K08874 - transformation/transcription domain-associated protein Alias (in v1)  Qrob_P0509310.1
Code Enzyme  EC:2.7.11.1 Gene Prediction Quality  manual_v1
Protein length 

Sequence

Length: 3896  
Kegg Orthology  K08874
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0 Synonyms

3 GO Terms

Identifier Name Description
GO:0005515 protein binding Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
GO:0005488 binding The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
GO:0016773 phosphotransferase activity, alcohol group as acceptor Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor).

32 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|vvi:100255847 1 3895 + 3895 Gaps:31 100.00 3906 90.12 0.0 TRRAP transformation/transcription domain-associated protein
blastp_kegg lcl|tcc:TCM_000213 1 3895 + 3895 Gaps:12 100.00 3899 90.43 0.0 Phosphatidylinositol 3- and 4-kinase family protein with FAT domain isoform 1
blastp_kegg lcl|pmum:103340296 1 3895 + 3895 Gaps:65 100.00 3926 89.23 0.0 transformation/transcription domain-associated protein
blastp_kegg lcl|pper:PRUPE_ppa000006mg 1 3895 + 3895 Gaps:66 100.00 3925 89.20 0.0 hypothetical protein
blastp_kegg lcl|pop:POPTR_0005s11640g 1 3895 + 3895 Gaps:52 100.00 3881 88.97 0.0 FAT domain-containing family protein
blastp_kegg lcl|cmo:103485125 1 3895 + 3895 Gaps:15 100.00 3890 88.07 0.0 transformation/transcription domain-associated protein-like
blastp_kegg lcl|cic:CICLE_v10024677mg 1 3895 + 3895 Gaps:25 100.00 3902 87.85 0.0 hypothetical protein
blastp_kegg lcl|cit:102618003 1 3895 + 3895 Gaps:25 100.00 3902 87.80 0.0 probable transcription-associated protein 1-like
blastp_kegg lcl|csv:101223090 1 3895 + 3895 Gaps:14 100.00 3889 87.94 0.0 TRRAP transformation/transcription domain-associated protein
blastp_kegg lcl|fve:101301041 1 3895 + 3895 Gaps:27 100.00 3894 88.29 0.0 transformation/transcription domain-associated protein-like
blastp_uniprot_sprot sp|Q9Y4A5|TRRAP_HUMAN 17 3895 + 3879 Gaps:414 93.47 3859 30.72 0.0 Transformation/transcription domain-associated protein OS Homo sapiens GN TRRAP PE 1 SV 3
blastp_uniprot_sprot sp|Q80YV3|TRRAP_MOUSE 1279 3895 + 2617 Gaps:334 99.45 2565 29.60 0.0 Transformation/transcription domain-associated protein OS Mus musculus GN Trrap PE 1 SV 2
blastp_uniprot_sprot sp|Q8I8U7|TRA1_DROME 80 3895 + 3816 Gaps:500 96.19 3803 27.91 3e-171 Transcription-associated protein 1 OS Drosophila melanogaster GN Nipped-A PE 1 SV 3
blastp_uniprot_sprot sp|Q9HFE8|TRA1_SCHPO 10 3894 + 3885 Gaps:373 96.97 3699 28.97 2e-169 Transcription-associated protein 1 OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN tra1 PE 3 SV 1
blastp_uniprot_sprot sp|P38811|TRA1_YEAST 1 3895 + 3895 Gaps:441 94.10 3744 29.61 2e-168 Transcription-associated protein 1 OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN TRA1 PE 1 SV 1
blastp_uniprot_sprot sp|Q10064|YAMB_SCHPO 66 3894 + 3829 Gaps:390 93.98 3655 29.05 4e-163 Uncharacterized PI3/PI4-kinase family protein C1F5.11c OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN SPAC1F5.11c PE 3 SV 1
blastp_uniprot_sprot sp|Q54T85|TRA1_DICDI 6 3895 + 3890 Gaps:372 65.74 4582 31.21 9e-151 Probable transcription-associated protein 1 OS Dictyostelium discoideum GN tra1 PE 3 SV 2
blastp_uniprot_sprot sp|Q6FRZ9|ATM_CANGA 3514 3895 + 382 Gaps:40 13.39 2763 25.68 4e-17 Serine/threonine-protein kinase TEL1 OS Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) GN TEL1 PE 3 SV 1
blastp_uniprot_sprot sp|Q02099|RAD3_SCHPO 3537 3895 + 359 Gaps:44 13.45 2386 25.55 5e-17 Protein kinase rad3 OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN rad3 PE 1 SV 2
blastp_uniprot_sprot sp|Q13535|ATR_HUMAN 3537 3894 + 358 Gaps:42 12.63 2644 26.95 3e-16 Serine/threonine-protein kinase ATR OS Homo sapiens GN ATR PE 1 SV 3
rpsblast_cdd gnl|CDD|119423 3519 3808 + 290 Gaps:39 100.00 253 41.50 1e-91 cd05163 TRRAP TRansformation/tRanscription domain-Associated Protein (TRRAP) pseudokinase domain The TRRAP catalytic domain is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs) aminoglycoside phosphotransferase choline kinase and RIO kinases. TRRAP shows some similarity to members of the phosphoinositide 3-kinase-related protein kinase (PIKK) subfamily in that it contains a FATC (FRAP ATM and TRRAP C-terminal) domain and has a large molecular weight. Unlike PIKK proteins however it contains an inactive PI3K-like pseudokinase domain which lacks the conserved residues necessary for ATP binding and catalytic activity. TRRAP also contains many motifs that may be critical for protein-protein interactions. TRRAP is a common component of many histone acetyltransferase (HAT) complexes and is responsible for the recruitment of these complexes to chromatin during transcription replication and DNA repair. TRRAP also exists in non-HAT complexes such as the p400 and MRN complexes which are implicated in ATP-dependent remodeling and DNA repair respectively..
rpsblast_cdd gnl|CDD|34637 2337 3895 + 1559 Gaps:235 54.25 2105 25.13 3e-42 COG5032 TEL1 Phosphatidylinositol kinase and protein kinases of the PI-3 kinase family [Signal transduction mechanisms / Cell division and chromosome partitioning / Chromatin structure and dynamics / DNA replication recombination and repair / Intracellular trafficking and secretion].
rpsblast_cdd gnl|CDD|202179 2807 3148 + 342 Gaps:75 99.71 350 26.65 5e-34 pfam02259 FAT FAT domain. The FAT domain is named after FRAP ATM and TRRAP.
rpsblast_cdd gnl|CDD|197542 3562 3808 + 247 Gaps:22 95.42 240 25.33 2e-29 smart00146 PI3Kc Phosphoinositide 3-kinase catalytic domain. Phosphoinositide 3-kinase isoforms participate in a variety of processes including cell motility the Ras pathway vesicle trafficking and secretion and apoptosis. These homologues may be either lipid kinases and/or protein kinases: the former phosphorylate the 3-position in the inositol ring of inositol phospholipids. The ataxia telangiectesia-mutated gene produced the targets of rapamycin (TOR) and the DNA-dependent kinase have not been found to possess lipid kinase activity. Some of this family possess PI-4 kinase activities.
rpsblast_cdd gnl|CDD|189554 3562 3807 + 246 Gaps:32 94.42 233 25.00 3e-22 pfam00454 PI3_PI4_kinase Phosphatidylinositol 3- and 4-kinase. Some members of this family probably do not have lipid kinase activity and are protein kinases .
rpsblast_cdd gnl|CDD|119429 3537 3808 + 272 Gaps:57 93.93 280 28.90 3e-14 cd05169 PIKKc_TOR TOR (Target of rapamycin) catalytic domain The TOR catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs) aminoglycoside phosphotransferase choline kinase and RIO kinases. TOR is a member of the phosphoinositide 3-kinase-related protein kinase (PIKK) subfamily. PIKKs have intrinsic serine/threonine kinase activity and are distinguished from other PKs by their unique catalytic domain similar to that of lipid PI3K and their large molecular weight (240-470 kDa). TOR contains a rapamycin binding domain a catalytic domain and a FATC (FRAP ATM and TRRAP C-terminal) domain at the C-terminus. It is also called FRAP (FK506 binding protein 12-rapamycin associated protein). TOR is a central component of the eukaryotic growth regulatory network. It controls the expression of many genes transcribed by all three RNA polymerases. It associates with other proteins to form two distinct complexes TORC1 and TORC2. TORC1 is involved in diverse growth-related functions including protein synthesis nutrient use and transport autophagy and stress responses. TORC2 is involved in organizing cytoskeletal structures..
rpsblast_cdd gnl|CDD|119416 3628 3801 + 174 Gaps:14 84.02 219 23.91 9e-14 cd00142 PI3Kc_like Phosphoinositide 3-kinase (PI3K)-like family catalytic domain The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs) aminoglycoside phosphotransferase choline kinase and RIO kinases. Members of the family include PI3K phosphoinositide 4-kinase (PI4K) PI3K-related protein kinases (PIKKs) and TRansformation/tRanscription domain-Associated Protein (TRRAP). PI3Ks catalyze the transfer of the gamma-phosphoryl group from ATP to the 3-hydroxyl of the inositol ring of D-myo-phosphatidylinositol (PtdIns) or its derivatives while PI4K catalyze the phosphorylation of the 4-hydroxyl of PtdIns. PIKKs are protein kinases that catalyze the phosphorylation of serine/threonine residues especially those that are followed by a glutamine. PI3Ks play an important role in a variety of fundamental cellular processes including cell motility the Ras pathway vesicle trafficking and secretion immune cell activation and apoptosis. PI4Ks produce PtdIns(4)P the major precursor to important signaling phosphoinositides. PIKKs have diverse functions including cell-cycle checkpoints genome surveillance mRNA surveillance and translation control..
rpsblast_cdd gnl|CDD|119431 3539 3807 + 269 Gaps:32 92.83 279 26.25 6e-13 cd05171 PIKKc_ATM Ataxia telangiectasia mutated (ATM) catalytic domain The ATM catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs) aminoglycoside phosphotransferase choline kinase and RIO kinases. ATM is a member of the phosphoinositide 3-kinase-related protein kinase (PIKK) subfamily. PIKKs have intrinsic serine/threonine kinase activity and are distinguished from other PKs by their unique catalytic domain similar to that of lipid PI3K and their large molecular weight (240-470 kDa). ATM contains a FAT (FRAP ATM and TRRAP) domain a catalytic domain and a FATC domain at the C-terminus. ATM is critical in the response to DNA double strand breaks (DSBs) caused by radiation. It is activated at the site of a DSB and phosphorylates key substrates that trigger pathways that regulate DNA repair and cell cycle checkpoints at the G1/S S phase and G2/M transition. Patients with the human genetic disorder Ataxia telangiectasia (A-T) caused by truncating mutations in ATM show genome instability increased cancer risk immunodeficiency compromised mobility and neurodegeneration. A-T displays clinical heterogeneity which is correlated to the degree of retained ATM activity..
rpsblast_cdd gnl|CDD|119424 3690 3775 + 86 none 38.74 222 31.40 8e-09 cd05164 PIKKc Phosphoinositide 3-kinase-related protein kinase (PIKK) subfamily catalytic domain The PIKK catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs) aminoglycoside phosphotransferase choline kinase and RIO kinases. Members include ATM (Ataxia telangiectasia mutated) ATR (Ataxia telangiectasia and Rad3-related) TOR (Target of rapamycin) SMG-1 (Suppressor of morphogenetic effect on genitalia-1) and DNA-PK (DNA-dependent protein kinase). PIKKs have intrinsic serine/threonine kinase activity and are distinguished from other PKs by their unique catalytic domain similar to that of lipid PI3K and their large molecular weight (240-470 kDa). They show strong preference for phosphorylating serine/threonine residues followed by a glutamine and are also referred to as (S/T)-Q-directed kinases. They all contain a FATC (FRAP ATM and TRRAP C-terminal) domain. PIKKs have diverse functions including cell-cycle checkpoints genome surveillance mRNA surveillance and translation control..
rpsblast_kog gnl|CDD|36107 1 3895 + 3895 Gaps:429 100.00 3550 42.56 0.0 KOG0889 KOG0889 KOG0889 Histone acetyltransferase SAGA TRRAP/TRA1 component PI-3 kinase superfamily [Signal transduction mechanisms Chromatin structure and dynamics Replication recombination and repair Cell cycle control cell division chromosome partitioning].

35 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Gene3D 2122 2145 24 G3DSA:1.25.40.10 none none IPR011990
Gene3D 3072 3136 65 G3DSA:1.25.40.10 none none IPR011990
Pfam 2809 3148 340 PF02259 none FAT domain IPR003151
SUPERFAMILY 3670 3846 177 SSF56112 none none IPR011009
SUPERFAMILY 3456 3628 173 SSF56112 none none IPR011009
Gene3D 1046 1082 37 G3DSA:1.25.10.10 none none IPR011989
Gene3D 992 1004 13 G3DSA:1.25.10.10 none none IPR011989
Gene3D 58 128 71 G3DSA:1.25.10.10 none none IPR011989
Gene3D 170 174 5 G3DSA:1.25.10.10 none none IPR011989
Gene3D 228 407 180 G3DSA:1.25.10.10 none none IPR011989
Gene3D 667 861 195 G3DSA:1.25.10.10 none none IPR011989
Gene3D 1124 1284 161 G3DSA:1.25.10.10 none none IPR011989
ProSiteProfiles 3549 3758 210 PS50290 none Phosphatidylinositol 3- and 4-kinases family profile. IPR000403
Gene3D 3847 3887 41 G3DSA:1.10.1070.11 none none IPR000403
Gene3D 3670 3808 139 G3DSA:1.10.1070.11 none none IPR000403
SUPERFAMILY 884 936 53 SSF48371 none none IPR016024
SUPERFAMILY 1120 1538 419 SSF48371 none none IPR016024
SUPERFAMILY 1040 1085 46 SSF48371 none none IPR016024
SUPERFAMILY 572 801 230 SSF48371 none none IPR016024
ProSiteProfiles 2676 3220 545 PS51189 none FAT domain profile. IPR014009
PANTHER 3315 3895 581 PTHR11139 none none none
PANTHER 1 1601 1601 PTHR11139 none none none
PANTHER 1630 3218 1589 PTHR11139 none none none
PANTHER 3315 3895 581 PTHR11139:SF1 none none none
PANTHER 1630 3218 1589 PTHR11139:SF1 none none none
Pfam 3562 3807 246 PF00454 none Phosphatidylinositol 3- and 4-kinase IPR000403
SUPERFAMILY 73 148 76 SSF48371 none none IPR016024
SUPERFAMILY 266 450 185 SSF48371 none none IPR016024
Coils 3350 3371 22 Coil none none none
SMART 3555 3863 309 SM00146 none Phosphoinositide 3-kinase, catalytic domain IPR000403

0 Localization

16 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Champenoux_2015_nPriLBD_3P Qrob_Chr10 10 v_15000_157 v_15000_310 15,68 15,9 15,91 lod 2.4 5.5
Bourran2_2014_nSecLBD_3P Qrob_Chr08 8 s_1BN2OD_551 s_1B5AYF_599 17,17 0 43,51 lod 1,9229 4,4
Bourran2_2014_nLBD*_3P Qrob_Chr08 8 v_5216_549 v_11837_70 12,25 0 35,55 lod 2,5951 6
Bourran2_2014_nP*_3P Qrob_Chr08 8 v_5216_549 v_11837_70 12,19 0 31,97 lod 2,8472 6
Bourran2_2002_QTL11_peak_Bud_burst_A4 Qrob_Chr06 6 s_1C41PA_791 s_1AM1AV_1141 19,17 0 34,57 lod 2,3 2,9
Bourran2_2014_aSeqBC_3P Qrob_Chr06 6 v_506_189 v_686_77 30,72 13,58 43,48 lod 2,2746 6,3
Bourran2_2014_aSeqBC*_A4 Qrob_Chr06 6 s_2F5MK3_712 v_444_355 27,13 14,86 39,46 lod 3,7847 9,8
Bourran2_2014_nEpis*_3P Qrob_Chr08 8 s_1DA4QW_688 s_1DNI7D_820 17,96 0 37,75 lod 2,9745 7,5
Bourran2_2014_nEpis*_A4 Qrob_Chr07 7 v_12400_446 s_1BPEBU_1211 6,93 0 15,13 lod 4,7411 11
Bourran2_2014_nFork*_3P Qrob_Chr06 6 v_12930_125 s_1AMZEI_909 34,28 7,43 41,48 lod 2,4044 5,5
Bourran2_2014_nLBD_A4 Qrob_Chr06 6 v_12930_125 s_1AMZEI_909 37,41 9,8 50,1 lod 1,9524 4,1
Bourran2_2014_nPriBD_A4 Qrob_Chr06 6 v_12930_125 s_1AMZEI_909 34,51 3,36 51,86 lod 1,6747 3,9
Bourran2_2014_nSecLBD_A4 Qrob_Chr07 7 v_8327_222 s_1A4WGY_363 16,04 0 44,69 lod 2,6373 6,5
Bourran2_2014_vEpiBC_A4 Qrob_Chr06 6 v_12930_125 s_1AMZEI_909 37,55 14,41 50,01 lod 1,7882 4,8
Champenoux_2015_nEpis_3P Qrob_Chr11 11 s_1DG9PM_867 s_1BZ083_1312 26,53 25,47 27,72 lod 4.4 8.9
Champenoux_2015_nP_3P Qrob_Chr06 6 s_1A386O_228 s_1AYZFS_603 27,03 26,47 27,34 lod 2.8 7.2

0 Targeting