| Analysis | rpsblast_cdd | Start | 3539 |
| End | 3807 | Strand | + |
| Length | 269 | Note | Gaps:32 |
| Hit Coverage | 92.83 | Hit Length | 279 |
| Hit Pident | 26.25 | E Val | 6e-13 |
| Hit Description | cd05171 PIKKc_ATM Ataxia telangiectasia mutated (ATM) catalytic domain The ATM catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs) aminoglycoside phosphotransferase choline kinase and RIO kinases. ATM is a member of the phosphoinositide 3-kinase-related protein kinase (PIKK) subfamily. PIKKs have intrinsic serine/threonine kinase activity and are distinguished from other PKs by their unique catalytic domain similar to that of lipid PI3K and their large molecular weight (240-470 kDa). ATM contains a FAT (FRAP ATM and TRRAP) domain a catalytic domain and a FATC domain at the C-terminus. ATM is critical in the response to DNA double strand breaks (DSBs) caused by radiation. It is activated at the site of a DSB and phosphorylates key substrates that trigger pathways that regulate DNA repair and cell cycle checkpoints at the G1/S S phase and G2/M transition. Patients with the human genetic disorder Ataxia telangiectasia (A-T) caused by truncating mutations in ATM show genome instability increased cancer risk immunodeficiency compromised mobility and neurodegeneration. A-T displays clinical heterogeneity which is correlated to the degree of retained ATM activity.. | Hit Pcons | 22.01 |
| Name | Qrob_P0200770.2 |
| Protein Identifier |
Organism . Name |
Score | Score Type | Protein Description | Alias (in v1) | Code Enzyme | Gene Prediction Quality |
|---|---|---|---|---|---|---|---|
| Qrob_P0200770.2 | Quercus robur | (M=1) K08874 - transformation/transcription domain-associated protein | Qrob_P0509310.1 | EC:2.7.11.1 | manual_v1 |
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