Protein : Qrob_P0184000.2 Q. robur
Protein Identifier  ? Qrob_P0184000.2 Organism . Name  Quercus robur
Score  85.1 Score Type  egn
Protein Description  (M=2) K06171 - nicastrin Gene Prediction Quality  validated
Protein length 

Sequence

Length: 369  
Kegg Orthology  K06171
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0 Synonyms

2 GO Terms

Identifier Name Description
GO:0016021 integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
GO:0016485 protein processing Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.

18 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|pmum:103342523 87 364 + 278 Gaps:33 71.67 406 73.20 9e-140 nicastrin-like
blastp_kegg lcl|tcc:TCM_043862 73 365 + 293 Gaps:59 49.85 666 64.76 1e-136 Zn-dependent exopeptidases superfamily protein isoform 1
blastp_kegg lcl|pmum:103328718 87 364 + 278 Gaps:59 73.38 432 67.19 2e-133 nicastrin-like
blastp_kegg lcl|vvi:100241276 70 365 + 296 Gaps:61 50.22 671 63.80 8e-131 nicastrin-like
blastp_kegg lcl|pper:PRUPE_ppa002463mg 87 364 + 278 Gaps:59 47.31 670 67.51 1e-130 hypothetical protein
blastp_kegg lcl|cic:CICLE_v10000514mg 75 365 + 291 Gaps:43 48.01 654 65.92 4e-128 hypothetical protein
blastp_kegg lcl|mdm:103406000 87 364 + 278 Gaps:59 79.65 398 63.72 3e-126 nicastrin
blastp_kegg lcl|cit:102608581 75 365 + 291 Gaps:59 46.94 703 62.73 3e-125 nicastrin-like
blastp_kegg lcl|fve:101308133 86 364 + 279 Gaps:58 37.09 860 63.64 2e-123 nicastrin-like
blastp_kegg lcl|pxb:103959888 91 364 + 274 Gaps:58 46.94 669 63.38 1e-121 nicastrin
blastp_uniprot_sprot sp|Q8GUM5|NICA_ARATH 74 365 + 292 Gaps:59 48.96 676 54.68 2e-108 Nicastrin OS Arabidopsis thaliana GN At3g52640/At3g52650 PE 2 SV 1
blastp_uniprot_sprot sp|Q54JT7|NICA_DICDI 102 346 + 245 Gaps:72 41.73 659 27.64 3e-20 Nicastrin OS Dictyostelium discoideum GN ncstn PE 3 SV 2
blastp_uniprot_sprot sp|P57716|NICA_MOUSE 255 347 + 93 Gaps:1 13.28 708 34.04 2e-10 Nicastrin OS Mus musculus GN Ncstn PE 1 SV 3
blastp_uniprot_sprot sp|Q8CGU6|NICA_RAT 255 347 + 93 Gaps:1 13.28 708 34.04 2e-10 Nicastrin OS Rattus norvegicus GN Ncstn PE 1 SV 1
blastp_uniprot_sprot sp|Q92542|NICA_HUMAN 255 347 + 93 Gaps:1 13.26 709 31.91 7e-10 Nicastrin OS Homo sapiens GN NCSTN PE 1 SV 2
rpsblast_cdd gnl|CDD|193502 255 346 + 92 Gaps:1 30.19 308 43.01 1e-24 cd03881 M28_Nicastrin M28 Zn-Peptidase Nicastrin a main component of gamma-secretase complex. Peptidase M28 family Nicastrin subfamily. Nicastrin is a main component of gamma-secretase complex. Its extracellular domain sequence resembles aminopeptidases but certain catalytic residues are not conserved. It is mainly localized to the endoplasmic reticulum and Golgi. It is highly glycosylated (Mr 120 kDa) and is essential for substrate recognition of the N-terminus of gamma-secretase substrates derived from APP and Notch. Nicastrin facilitates substrate cleavage by the catalytic presenilin subunit in the gamma-secretase complex. One conserved glutamate is especially important probably because this residue forms an ion pair with the amino terminus of the substrate. This substrate-binding domain is often called the DAP domain (named after DYIGS the amino acid stretch that modulates amyloid precursor protein (APP) processing and Peptidase homologous region). The sequence of the substrate N-terminus is apparently not critical for the interaction but a free amino group is. Thus nicastrin can be considered a kind of gatekeeper for the gamma-secretase complex: type I membrane proteins that have not shed their ectodomains cannot interact properly with nicastrin and do not gain access to the active site.
rpsblast_cdd gnl|CDD|114188 273 364 + 92 Gaps:6 43.17 227 35.71 6e-24 pfam05450 Nicastrin Nicastrin. Nicastrin and presenilin are two major components of the gamma-secretase complex which executes the intramembrane proteolysis of type I integral membrane proteins such as the amyloid precursor protein (APP) and Notch. Nicastrin is synthesised in fibroblasts and neurons as an endoglycosidase-H-sensitive glycosylated precursor protein (immature nicastrin) and is then modified by complex glycosylation in the Golgi apparatus and by sialylation in the trans-Golgi network (mature nicastrin). A region featured in this family has a fold similar to human transferrin receptor (TfR) and a bacterial aminopeptidase. It is implicated in the pathogenesis of Alzheimer's disease.
rpsblast_kog gnl|CDD|37868 106 364 + 259 Gaps:28 45.13 596 22.68 8e-33 KOG2657 KOG2657 KOG2657 Transmembrane glycoprotein nicastrin [Signal transduction mechanisms Posttranslational modification protein turnover chaperones].

5 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
PANTHER 68 361 294 PTHR21092 none none IPR008710
Pfam 273 364 92 PF05450 none Nicastrin IPR008710
Gene3D 267 354 88 G3DSA:3.40.630.10 none none none
PANTHER 68 361 294 PTHR21092:SF0 none none none
SUPERFAMILY 267 359 93 SSF53187 none none none

0 Localization

0 Qtllist

0 Targeting