| Analysis | rpsblast_cdd | Start | 273 |
| End | 364 | Strand | + |
| Length | 92 | Note | Gaps:6 |
| Hit Coverage | 43.17 | Hit Length | 227 |
| Hit Pident | 35.71 | E Val | 6e-24 |
| Hit Description | pfam05450 Nicastrin Nicastrin. Nicastrin and presenilin are two major components of the gamma-secretase complex which executes the intramembrane proteolysis of type I integral membrane proteins such as the amyloid precursor protein (APP) and Notch. Nicastrin is synthesised in fibroblasts and neurons as an endoglycosidase-H-sensitive glycosylated precursor protein (immature nicastrin) and is then modified by complex glycosylation in the Golgi apparatus and by sialylation in the trans-Golgi network (mature nicastrin). A region featured in this family has a fold similar to human transferrin receptor (TfR) and a bacterial aminopeptidase. It is implicated in the pathogenesis of Alzheimer's disease. | Hit Pcons | 21.43 |
| Name | Qrob_P0184000.2 |
| Protein Identifier |
Organism . Name |
Score | Score Type | Protein Description | Alias (in v1) | Code Enzyme | Gene Prediction Quality |
|---|---|---|---|---|---|---|---|
| Qrob_P0184000.2 | Quercus robur | 85.1 | egn | (M=2) K06171 - nicastrin | validated |
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