Protein : Qrob_P0108880.2 Q. robur
Protein Identifier  ? Qrob_P0108880.2 Organism . Name  Quercus robur
Score  2.1 Score Type  egn
Protein Description  (M=2) PF14429 - C2 domain in Dock180 and Zizimin proteins Gene Prediction Quality  validated
Protein length 

Sequence

Length: 758  
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0 Synonyms

2 GO Terms

Identifier Name Description
GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals.
GO:0005085 guanyl-nucleotide exchange factor activity Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.

25 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|cam:101495183 1 744 + 744 Gaps:16 41.29 1836 81.40 0.0 dedicator of cytokinesis protein 6-like
blastp_kegg lcl|pper:PRUPE_ppa000097mg 1 744 + 744 Gaps:18 41.16 1832 82.63 0.0 hypothetical protein
blastp_kegg lcl|mdm:103445874 1 744 + 744 Gaps:18 41.13 1833 82.63 0.0 dedicator of cytokinesis protein 7-like
blastp_kegg lcl|mdm:103435388 1 744 + 744 Gaps:23 41.04 1830 83.22 0.0 dedicator of cytokinesis protein 11-like
blastp_kegg lcl|gmx:100803721 1 744 + 744 Gaps:23 41.25 1835 79.39 0.0 dedicator of cytokinesis protein 7-like
blastp_kegg lcl|pvu:PHAVU_011G1776000 1 744 + 744 Gaps:21 56.98 1325 79.60 0.0 hypothetical protein
blastp_kegg lcl|pmum:103325730 1 744 + 744 Gaps:18 41.16 1832 82.36 0.0 dedicator of cytokinesis protein 7
blastp_kegg lcl|cit:102613047 6 744 + 739 Gaps:16 40.73 1834 82.33 0.0 dedicator of cytokinesis protein 11-like
blastp_kegg lcl|pop:POPTR_0011s00640g 22 744 + 723 Gaps:15 39.83 1848 80.30 0.0 POPTRDRAFT_889019 SPIKE family protein
blastp_kegg lcl|vvi:100259293 8 744 + 737 Gaps:19 40.82 1847 81.30 0.0 dedicator of cytokinesis protein 11-like
blastp_uniprot_sprot sp|Q8BIK4|DOCK9_MOUSE 448 714 + 267 Gaps:23 13.92 2055 29.02 3e-23 Dedicator of cytokinesis protein 9 OS Mus musculus GN Dock9 PE 2 SV 2
blastp_uniprot_sprot sp|Q96BY6|DOC10_HUMAN 435 743 + 309 Gaps:28 14.87 2186 26.15 7e-22 Dedicator of cytokinesis protein 10 OS Homo sapiens GN DOCK10 PE 1 SV 3
blastp_uniprot_sprot sp|Q8BZN6|DOC10_MOUSE 435 743 + 309 Gaps:28 15.12 2150 26.77 1e-21 Dedicator of cytokinesis protein 10 OS Mus musculus GN Dock10 PE 1 SV 3
blastp_uniprot_sprot sp|Q9BZ29|DOCK9_HUMAN 448 719 + 272 Gaps:28 13.82 2069 28.32 2e-21 Dedicator of cytokinesis protein 9 OS Homo sapiens GN DOCK9 PE 1 SV 2
blastp_uniprot_sprot sp|Q96HP0|DOCK6_HUMAN 457 719 + 263 Gaps:45 14.17 2047 30.34 2e-17 Dedicator of cytokinesis protein 6 OS Homo sapiens GN DOCK6 PE 1 SV 3
blastp_uniprot_sprot sp|Q8NF50|DOCK8_HUMAN 457 719 + 263 Gaps:35 14.01 2099 27.89 4e-17 Dedicator of cytokinesis protein 8 OS Homo sapiens GN DOCK8 PE 1 SV 3
blastp_uniprot_sprot sp|Q8VDR9|DOCK6_MOUSE 457 724 + 268 Gaps:41 14.18 2080 27.80 8e-17 Dedicator of cytokinesis protein 6 OS Mus musculus GN Dock6 PE 1 SV 4
blastp_uniprot_sprot sp|Q5JSL3|DOC11_HUMAN 449 753 + 305 Gaps:34 15.29 2073 25.24 2e-16 Dedicator of cytokinesis protein 11 OS Homo sapiens GN DOCK11 PE 1 SV 2
blastp_uniprot_sprot sp|Q8C147|DOCK8_MOUSE 457 719 + 263 Gaps:39 14.00 2100 27.21 3e-16 Dedicator of cytokinesis protein 8 OS Mus musculus GN Dock8 PE 1 SV 4
blastp_uniprot_sprot sp|A2AF47|DOC11_MOUSE 449 719 + 271 Gaps:29 13.80 2073 25.52 3e-16 Dedicator of cytokinesis protein 11 OS Mus musculus GN Dock11 PE 1 SV 1
rpsblast_cdd gnl|CDD|206348 454 623 + 170 Gaps:8 98.88 178 35.23 1e-38 pfam14180 DOCK_C2 GTP-GDP exchange factor. Dock proteins are atypical GTP-GDP exchange factors for the small GTPases Pac and Cdc42 and are implicated in biological roles related to cell-migration and phagocytosis.
rpsblast_cdd gnl|CDD|206595 449 623 + 175 Gaps:12 100.00 179 32.96 1e-36 pfam14429 DOCK-C2 C2 domain in Dock180 and Zizimin proteins. The Dock180/Dock1 and Zizimin proteins are atypical GTP/GDP exchange factors for the small GTPases Rac and Cdc42 and are implicated cell-migration and phagocytosis. Across all Dock180 proteins two regions are conserved: C-terminus termed CZH2 or DHR2 (or the Dedicator of cytokinesis) whereas CZH1/DHR1 contain a new family of the C2 domain.
rpsblast_cdd gnl|CDD|176061 453 623 + 171 Gaps:19 100.00 178 34.27 2e-32 cd08679 C2_DOCK180_related C2 domains found in Dedicator Of CytoKinesis 1 (DOCK 180) and related proteins. Dock180 was first identified as an 180kd proto-oncogene product c-Crk-interacting protein involved in actin cytoskeletal changes. It is now known that it has Rac-specific GEF activity but lacks the conventional Dbl homology (DH) domain. There are 10 additional related proteins that can be divided into four classes based on sequence similarity and domain organization: Dock-A which includes Dock180/Dock1 Dock2 and Dock5 Dock-B which includes Dock3/MOCA (modifier of cell adhesion) and Dock4 Dock-C which includes Dock6/Zir1 Dock7/Zir2 and Dock8/Zir3 and Dock-D which includes Dock9/Zizimin1 Dock10/Zizimin3 and Dock11/Zizimin2/ACG (activated Cdc42-associated GEF). Most of members of classes Dock-A and Dock-B are the GEFs specific for Rac. Those of Dock-D are Cdc42-specific GEFs while those of Dock-C are the GEFs for both. All Dock180-related proteins have two common homology domains: the C2 domain (AKA Dock homology region (DHR)-1 CED-5 Dock180 MBC-zizimin homology (CZH) 1) and the DHR-2 (AKA CZH2 or Docker). DHR-2 has the catalytic activity for Rac and/or Cdc42 but is structurally unrelated to the DH domain. The C2/DHR-1 domains of Dock180 and Dock4 have been shown to bind phosphatidylinositol-3 4 5-triphosphate (PtdIns(3 4 5)P3). The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids inositol polyphosphates and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain such as protein kinase C or membrane trafficking proteins which contain at least two C2 domains such as synaptotagmin 1. However there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues primarily aspartates that serve as ligands for calcium ions.
rpsblast_cdd gnl|CDD|176078 457 618 + 162 Gaps:18 94.97 179 31.76 9e-20 cd08696 C2_Dock-C C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins. Dock-C is one of 4 classes of Dock family proteins. The members here include: Dock6/Zir1 Dock7/Zir2 and Dock8/Zir3. Dock-C members are GEFs for both Rac and Cdc42. In addition to the C2 domain (AKA Dock homology region (DHR)-1 CED-5 Dock180 MBC-zizimin homology (CZH) 1) and the DHR-2 (AKA CZH2 or Docker) which all Dock180-related proteins have Dock-C members contain a functionally uncharacterized domain upstream of the C2 domain. DHR-2 has the catalytic activity for Rac and/or Cdc42 but is structurally unrelated to the DH domain. The C2/DHR-1 domains of Dock180 and Dock4 have been shown to bind phosphatidylinositol-3 4 5-triphosphate (PtdIns(3 4 5)P3). The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids inositol polyphosphates and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain such as protein kinase C or membrane trafficking proteins which contain at least two C2 domains such as synaptotagmin 1. However there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues primarily aspartates that serve as ligands for calcium ions.
rpsblast_cdd gnl|CDD|176079 457 617 + 161 Gaps:20 94.59 185 33.14 2e-19 cd08697 C2_Dock-D C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins. Dock-D is one of 4 classes of Dock family proteins. The members here include: Dock9/Zizimin1 Dock10/Zizimin3 and Dock11/Zizimin2/ACG (activated Cdc42-associated GEF). Dock-D are Cdc42-specific GEFs. In addition to the C2 domain (AKA Dock homology region (DHR)-1 CED-5 Dock180 MBC-zizimin homology (CZH) 1) and the DHR-2 (AKA CZH2 or Docker) which all Dock180-related proteins have Dock-D members contain a functionally uncharacterized domain and a PH domain upstream of the C2 domain. DHR-2 has the catalytic activity for Rac and/or Cdc42 but is structurally unrelated to the DH domain. The C2/DHR-1 domains of Dock180 and Dock4 have been shown to bind phosphatidylinositol-3 4 5-triphosphate (PtdIns(3 4 5)P3). The PH domain broadly binds to phospholipids and is thought to be involved in targeting the plasma membrane. The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids inositol polyphosphates and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain such as protein kinase C or membrane trafficking proteins which contain at least two C2 domains such as synaptotagmin 1. However there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues primarily aspartates that serve as ligands for calcium ions.

6 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
PANTHER 8 271 264 PTHR23317:SF76 none none none
PANTHER 8 271 264 PTHR23317 none none IPR026791
PANTHER 318 745 428 PTHR23317:SF76 none none none
Pfam 449 622 174 PF14429 none C2 domain in Dock180 and Zizimin proteins IPR027007
ProSiteProfiles 454 613 160 PS51650 none DHR-1 domain profile. IPR027007
PANTHER 318 745 428 PTHR23317 none none IPR026791

0 Localization

8 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran2_2014_vSeqBC_3P Qrob_Chr10 10 s_1A6CK6_610 v_7092_29 4,28 0 23,27 lod 2,8619 7
Bourran2_2014_nFork*_3P Qrob_Chr06 6 v_12930_125 s_1AMZEI_909 34,28 7,43 41,48 lod 2,4044 5,5
Bourran2_2015_nSeqBC_3P Qrob_Chr11 11 s_1DG9PM_867 s_1BZ083_1312 26,06 25,47 27,72 lod 3.6 7.1
Bourran2_2015_nP_3P Qrob_Chr12 12 v_10140_295 v_838_303 16 14,69 18,01 lod 5.1 13.7
Bourran1_2004_QTL4_peak_Bud_burst_3P Qrob_Chr04 4 s_1AHUWN_1101 s_1BRNG7_1618 30,55 0 47,55 lod 2,8 7,4
Bourran2_2002_QTL10_peak_Bud_burst_A4 Qrob_Chr04 4 s_1B59MJ_737 s_1BGLSD_999 15,86 0 41,66 lod 2,8 4
Bourran1_2000_QTL3_peak_Bud_burst_3P Qrob_Chr04 4 s_1A6DJQ_418 s_1A1PEC_1268 23,09 9,09 44,09 lod 2,3 6,8
NancyGreenhouseCO2_2001_ambient_elevated_leaf_cellulose_QTL7_d13Cf Qrob_Chr04 4 s_1B91MJ_705 s_1AHIKX_640 33.92 12,11 48,31 lod 6.1865 0.023

0 Targeting