| Analysis | rpsblast_cdd | Start | 457 |
| End | 618 | Strand | + |
| Length | 162 | Note | Gaps:18 |
| Hit Coverage | 94.97 | Hit Length | 179 |
| Hit Pident | 31.76 | E Val | 9e-20 |
| Hit Description | cd08696 C2_Dock-C C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins. Dock-C is one of 4 classes of Dock family proteins. The members here include: Dock6/Zir1 Dock7/Zir2 and Dock8/Zir3. Dock-C members are GEFs for both Rac and Cdc42. In addition to the C2 domain (AKA Dock homology region (DHR)-1 CED-5 Dock180 MBC-zizimin homology (CZH) 1) and the DHR-2 (AKA CZH2 or Docker) which all Dock180-related proteins have Dock-C members contain a functionally uncharacterized domain upstream of the C2 domain. DHR-2 has the catalytic activity for Rac and/or Cdc42 but is structurally unrelated to the DH domain. The C2/DHR-1 domains of Dock180 and Dock4 have been shown to bind phosphatidylinositol-3 4 5-triphosphate (PtdIns(3 4 5)P3). The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids inositol polyphosphates and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain such as protein kinase C or membrane trafficking proteins which contain at least two C2 domains such as synaptotagmin 1. However there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues primarily aspartates that serve as ligands for calcium ions. | Hit Pcons | 22.35 |
| Name | Qrob_P0108880.2 |
| Protein Identifier |
Organism . Name |
Score | Score Type | Protein Description | Alias (in v1) | Code Enzyme | Gene Prediction Quality |
|---|---|---|---|---|---|---|---|
| Qrob_P0108880.2 | Quercus robur | 2.1 | egn | (M=2) PF14429 - C2 domain in Dock180 and Zizimin proteins | validated |
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