| Analysis | rpsblast_cdd | Start | 457 |
| End | 617 | Strand | + |
| Length | 161 | Note | Gaps:20 |
| Hit Coverage | 94.59 | Hit Length | 185 |
| Hit Pident | 33.14 | E Val | 2e-19 |
| Hit Description | cd08697 C2_Dock-D C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins. Dock-D is one of 4 classes of Dock family proteins. The members here include: Dock9/Zizimin1 Dock10/Zizimin3 and Dock11/Zizimin2/ACG (activated Cdc42-associated GEF). Dock-D are Cdc42-specific GEFs. In addition to the C2 domain (AKA Dock homology region (DHR)-1 CED-5 Dock180 MBC-zizimin homology (CZH) 1) and the DHR-2 (AKA CZH2 or Docker) which all Dock180-related proteins have Dock-D members contain a functionally uncharacterized domain and a PH domain upstream of the C2 domain. DHR-2 has the catalytic activity for Rac and/or Cdc42 but is structurally unrelated to the DH domain. The C2/DHR-1 domains of Dock180 and Dock4 have been shown to bind phosphatidylinositol-3 4 5-triphosphate (PtdIns(3 4 5)P3). The PH domain broadly binds to phospholipids and is thought to be involved in targeting the plasma membrane. The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids inositol polyphosphates and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain such as protein kinase C or membrane trafficking proteins which contain at least two C2 domains such as synaptotagmin 1. However there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues primarily aspartates that serve as ligands for calcium ions. | Hit Pcons | 18.29 |
| Name | Qrob_P0108880.2 |
| Protein Identifier |
Organism . Name |
Score | Score Type | Protein Description | Alias (in v1) | Code Enzyme | Gene Prediction Quality |
|---|---|---|---|---|---|---|---|
| Qrob_P0108880.2 | Quercus robur | 2.1 | egn | (M=2) PF14429 - C2 domain in Dock180 and Zizimin proteins | validated |
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