Protein : Qrob_P0103090.2 Q. robur
Protein Identifier  ? Qrob_P0103090.2 Organism . Name  Quercus robur
Score  4.6 Score Type  egn
Protein Description  (M=1) 1.3.1.72 - Delta(24)-sterol reductase. Code Enzyme  EC:1.3.1.72
Gene Prediction Quality  validated Protein length 

Sequence

Length: 568  
Kegg Orthology  K09828
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0 Synonyms

6 GO Terms

Identifier Name Description
GO:0016491 oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
GO:0055114 oxidation-reduction process A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0050660 flavin adenine dinucleotide binding Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
GO:0008762 UDP-N-acetylmuramate dehydrogenase activity Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+.
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.

26 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|pop:POPTR_0008s08440g 1 561 + 561 none 99.64 563 89.13 0.0 POPTRDRAFT_564011 POPTRDRAFT_765722 diminuto family protein
blastp_kegg lcl|gmx:100814521 1 567 + 567 none 100.00 567 87.48 0.0 delta(24)-sterol reductase-like
blastp_kegg lcl|pop:POPTR_0010s17710g 1 561 + 561 none 99.64 563 88.06 0.0 POPTRDRAFT_822314 diminuto family protein
blastp_kegg lcl|rcu:RCOM_1386000 1 567 + 567 none 100.00 567 88.18 0.0 Cell elongation protein diminuto putative
blastp_kegg lcl|rcu:RCOM_1138510 1 567 + 567 none 100.00 567 87.83 0.0 Cell elongation protein diminuto putative
blastp_kegg lcl|pxb:103943196 1 567 + 567 none 99.82 568 87.13 0.0 delta(24)-sterol reductase
blastp_kegg lcl|mdm:103403411 1 567 + 567 none 99.82 568 86.95 0.0 delta(24)-sterol reductase-like
blastp_kegg lcl|gmx:100791799 1 567 + 567 none 100.00 567 86.60 0.0 delta(24)-sterol reductase-like
blastp_kegg lcl|cam:101507942 1 567 + 567 none 100.00 567 86.77 0.0 delta(24)-sterol reductase-like
blastp_kegg lcl|mdm:103451474 1 567 + 567 none 99.82 568 87.13 0.0 delta(24)-sterol reductase
blastp_uniprot_sprot sp|P93472|DIM_PEA 1 567 + 567 none 100.00 567 86.07 0.0 Delta(24)-sterol reductase OS Pisum sativum GN DIM PE 1 SV 1
blastp_uniprot_sprot sp|Q39085|DIM_ARATH 1 563 + 563 Gaps:4 100.00 561 81.82 0.0 Delta(24)-sterol reductase OS Arabidopsis thaliana GN DIM PE 1 SV 2
blastp_uniprot_sprot sp|Q15392|DHC24_HUMAN 20 541 + 522 Gaps:41 94.77 516 44.17 1e-124 Delta(24)-sterol reductase OS Homo sapiens GN DHCR24 PE 1 SV 2
blastp_uniprot_sprot sp|Q60HC5|DHC24_MACFA 20 541 + 522 Gaps:41 94.77 516 44.17 2e-124 Delta(24)-sterol reductase OS Macaca fascicularis GN DHCR24 PE 2 SV 2
blastp_uniprot_sprot sp|Q5BQE6|DHC24_RAT 20 541 + 522 Gaps:41 94.77 516 43.76 6e-124 Delta(24)-sterol reductase OS Rattus norvegicus GN Dhcr24 PE 2 SV 2
blastp_uniprot_sprot sp|Q8VCH6|DHC24_MOUSE 20 541 + 522 Gaps:41 94.77 516 43.76 1e-123 Delta(24)-sterol reductase OS Mus musculus GN Dhcr24 PE 2 SV 1
blastp_uniprot_sprot sp|O17397|DIML_CAEEL 9 542 + 534 Gaps:52 98.29 525 37.79 5e-105 Diminuto-like protein OS Caenorhabditis elegans GN F52H2.6 PE 3 SV 1
blastp_uniprot_sprot sp|P72056|DPRE1_MYCTU 109 260 + 152 Gaps:2 32.97 461 25.00 3e-08 Probable decaprenylphosphoryl-beta-D-ribose oxidase OS Mycobacterium tuberculosis GN dprE1 PE 1 SV 1
blastp_uniprot_sprot sp|Q90YK3|GGLO_SCYTO 64 246 + 183 Gaps:17 40.00 440 23.86 2e-07 L-gulonolactone oxidase OS Scyliorhinus torazame GN GULO PE 2 SV 1
blastp_uniprot_sprot sp|P58710|GGLO_MOUSE 92 229 + 138 Gaps:2 30.91 440 24.26 8e-07 L-gulonolactone oxidase OS Mus musculus GN Gulo PE 1 SV 3
rpsblast_cdd gnl|CDD|201863 109 199 + 91 Gaps:1 66.19 139 41.30 3e-16 pfam01565 FAD_binding_4 FAD binding domain. This family consists of various enzymes that use FAD as a co-factor most of the enzymes are similar to oxygen oxidoreductase. One of the enzymes Vanillyl-alcohol oxidase (VAO) has a solved structure the alignment includes the FAD binding site called the PP-loop between residues 99-110. The FAD molecule is covalently bound in the known structure however the residue that links to the FAD is not in the alignment. VAO catalyzes the oxidation of a wide variety of substrates ranging form aromatic amines to 4-alkylphenols. Other members of this family include D-lactate dehydrogenase this enzyme catalyzes the conversion of D-lactate to pyruvate using FAD as a co-factor mitomycin radical oxidase this enzyme oxidises the reduced form of mitomycins and is involved in mitomycin resistance. This family includes MurB an UDP-N-acetylenolpyruvoylglucosamine reductase enzyme EC:1.1.1.158. This enzyme is involved in the biosynthesis of peptidoglycan.
rpsblast_cdd gnl|CDD|30625 109 237 + 129 Gaps:5 29.19 459 33.58 2e-14 COG0277 GlcD FAD/FMN-containing dehydrogenases [Energy production and conversion].
rpsblast_cdd gnl|CDD|162481 107 420 + 314 Gaps:58 62.10 438 25.37 3e-11 TIGR01678 FAD_lactone_ox sugar 1 4-lactone oxidases. This model represents a family of at least two different sugar 1 4 lactone oxidases both involved in synthesizing ascorbic acid or a derivative. These include L-gulonolactone oxidase (EC 1.1.3.8) from rat and D-arabinono-1 4-lactone oxidase (EC 1.1.3.37) from Saccharomyces cerevisiae. Members are proposed to have the cofactor FAD covalently bound at a site specified by Prosite motif PS00862 OX2_COVAL_FAD 1.
rpsblast_cdd gnl|CDD|129482 112 258 + 147 Gaps:10 36.56 413 29.80 1e-08 TIGR00387 glcD glycolate oxidase subunit GlcD. This protein the glycolate oxidase GlcD subunit is similar in sequence to that of several D-lactate dehydrogenases including that of E. coli. The glycolate oxidase has been found to have some D-lactate dehydrogenase activity.
rpsblast_kog gnl|CDD|36476 9 555 + 547 Gaps:15 98.71 543 48.88 0.0 KOG1262 KOG1262 KOG1262 FAD-binding protein DIMINUTO [General function prediction only].
rpsblast_kog gnl|CDD|36445 29 231 + 203 Gaps:12 41.39 505 20.57 1e-08 KOG1231 KOG1231 KOG1231 Proteins containing the FAD binding domain [Energy production and conversion].

9 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Phobius 1 19 19 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
SUPERFAMILY 105 229 125 SSF56176 none none IPR016166
Gene3D 116 230 115 G3DSA:3.30.465.10 none none IPR016169
ProSiteProfiles 52 231 180 PS51387 none PCMH-type FAD-binding domain profile. IPR016166
Phobius 47 567 521 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
PANTHER 1 553 553 PTHR10801 none none none
Pfam 109 198 90 PF01565 "KEGG:00520+1.3.1.98","KEGG:00550+1.3.1.98","MetaCyc:PWY-6386","MetaCyc:PWY-6387","UniPathway:UPA00219" FAD binding domain IPR006094
PANTHER 1 553 553 PTHR10801:SF0 none none none
Phobius 20 46 27 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none

1 Localization

Analysis Start End Length
TMHMM 21 43 22

5 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran_2000_2002_QTL6_Delta.F Qrob_Chr03 3 s_2HYXJ2_207 s_1AUAXK_317 29.12 6,3 45,37 lod 3.1666 0.026
Bourran2_2014_nLBD_3P Qrob_Chr03 3 s_1ET7H8_604 s_1BYNB5_834 23,73 0 46,72 lod 1,7573 3,8
PM_1999_QTL14_peak_Bud_burst_3P Qrob_Chr03 3 s_2F0SI1_756 v_6056_735 11,78 3,78 50,78 lod 2,5 4,5
Bourran2_2014_nFork*_3P Qrob_Chr06 6 v_12930_125 s_1AMZEI_909 34,28 7,43 41,48 lod 2,4044 5,5
Bourran2_2014_rEpiBC*_3P Qrob_Chr03 3 s_1A3B3X_1163 s_1DKGMO_450 23,04 4,92 41,12 lod 2,5668 7

0 Targeting