Protein : Qrob_P0050350.2 Q. robur
Protein Identifier  ? Qrob_P0050350.2 Organism . Name  Quercus robur
Score  25.0 Score Type  egn
Protein Description  (M=2) PTHR23273//PTHR23273:SF0 - REPLICATION FACTOR A 1, RFA1 // SUBFAMILY NOT NAMED Gene Prediction Quality  validated
Protein length 

Sequence

Length: 519  
Kegg Orthology  K07466
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0 Synonyms

4 GO Terms

Identifier Name Description
GO:0003677 DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GO:0003676 nucleic acid binding Interacting selectively and non-covalently with any nucleic acid.
GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
GO:0006260 DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

33 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|vvi:100263039 1 516 + 516 Gaps:33 59.30 882 66.16 0.0 replication protein A 70 kDa DNA-binding subunit-like
blastp_kegg lcl|cmo:103490723 5 516 + 512 Gaps:24 59.23 861 62.94 0.0 replication protein A 70 kDa DNA-binding subunit A
blastp_kegg lcl|csv:101211358 5 516 + 512 Gaps:24 59.23 861 62.35 0.0 replication protein A 70 kDa DNA-binding subunit-like
blastp_kegg lcl|cam:101512477 1 511 + 511 Gaps:32 56.82 917 60.65 0.0 replication protein A 70 kDa DNA-binding subunit-like
blastp_kegg lcl|gmx:100778597 1 516 + 516 Gaps:29 56.26 894 62.03 0.0 replication protein A 70 kDa DNA-binding subunit C-like
blastp_kegg lcl|pop:POPTR_0003s10170g 3 516 + 514 Gaps:19 59.84 854 60.67 0.0 POPTRDRAFT_646356 hypothetical protein
blastp_kegg lcl|tcc:TCM_016675 1 516 + 516 Gaps:52 61.91 911 57.80 0.0 Replication factor A 1 rfa1 putative
blastp_kegg lcl|rcu:RCOM_0866490 3 516 + 514 Gaps:37 59.16 901 58.16 0.0 replication factor A 1 rfa1 putative
blastp_kegg lcl|pvu:PHAVU_002G128800g 1 516 + 516 Gaps:19 59.01 866 59.30 0.0 hypothetical protein
blastp_kegg lcl|cic:CICLE_v10000254mg 1 516 + 516 Gaps:40 57.81 858 60.89 0.0 hypothetical protein
blastp_pdb 1fgu_B 267 516 + 250 Gaps:16 97.62 252 43.90 1e-58 mol:protein length:252 REPLICATION PROTEIN A 70 KDA DNA-BINDING SUBU
blastp_pdb 1fgu_A 267 516 + 250 Gaps:16 97.62 252 43.90 1e-58 mol:protein length:252 REPLICATION PROTEIN A 70 KDA DNA-BINDING SUBU
blastp_pdb 1jmc_A 267 510 + 244 Gaps:16 97.56 246 43.33 2e-56 mol:protein length:246 PROTEIN (REPLICATION PROTEIN A (RPA))
blastp_pdb 1ynx_A 276 374 + 99 Gaps:1 85.96 114 44.90 2e-21 mol:protein length:114 Replication factor-A protein 1
blastp_pdb 2b3g_A 1 124 + 124 Gaps:17 95.12 123 32.48 4e-07 mol:protein length:123 Replication protein A 70 kDa DNA-binding subu
blastp_pdb 2b29_A 1 124 + 124 Gaps:17 95.12 123 32.48 4e-07 mol:protein length:123 Replication protein A 70 kDa DNA-binding subu
blastp_uniprot_sprot sp|Q9FHJ6|RFA1C_ARATH 1 516 + 516 Gaps:59 64.60 853 49.18 2e-165 Replication protein A 70 kDa DNA-binding subunit C OS Arabidopsis thaliana GN RPA1C PE 3 SV 1
blastp_uniprot_sprot sp|F4JSG3|RFA1E_ARATH 1 516 + 516 Gaps:45 61.35 784 51.98 8e-154 Replication protein A 70 kDa DNA-binding subunit E OS Arabidopsis thaliana GN RPA1E PE 2 SV 1
blastp_uniprot_sprot sp|Q9SKI4|RFA1A_ARATH 1 516 + 516 Gaps:76 70.31 640 53.11 4e-142 Replication protein A 70 kDa DNA-binding subunit A OS Arabidopsis thaliana GN RPA1A PE 1 SV 1
blastp_uniprot_sprot sp|Q6YZ49|RFA1A_ORYSJ 20 516 + 497 Gaps:62 68.45 656 51.00 1e-128 Replication protein A 70 kDa DNA-binding subunit A OS Oryza sativa subsp. japonica GN RPA1A PE 1 SV 1
blastp_uniprot_sprot sp|Q65XV7|RFA1C_ORYSJ 1 516 + 516 Gaps:91 58.99 951 42.78 1e-128 Replication protein A 70 kDa DNA-binding subunit C OS Oryza sativa subsp. japonica GN RPA1C PE 1 SV 1
blastp_uniprot_sprot sp|Q5ZJJ2|RFA1_CHICK 1 516 + 516 Gaps:115 69.22 614 39.76 5e-64 Replication protein A 70 kDa DNA-binding subunit OS Gallus gallus GN RPA1 PE 2 SV 1
blastp_uniprot_sprot sp|Q8VEE4|RFA1_MOUSE 1 518 + 518 Gaps:103 70.47 623 38.27 5e-62 Replication protein A 70 kDa DNA-binding subunit OS Mus musculus GN Rpa1 PE 2 SV 1
blastp_uniprot_sprot sp|Q6NY74|RFA1_DANRE 248 516 + 269 Gaps:18 44.43 601 41.57 1e-58 Replication protein A 70 kDa DNA-binding subunit OS Danio rerio GN rpa1 PE 1 SV 1
blastp_uniprot_sprot sp|P27694|RFA1_HUMAN 267 516 + 250 Gaps:16 39.94 616 43.90 1e-54 Replication protein A 70 kDa DNA-binding subunit OS Homo sapiens GN RPA1 PE 1 SV 2
blastp_uniprot_sprot sp|Q01588|RFA1_XENLA 1 516 + 516 Gaps:37 59.61 609 41.05 8e-54 Replication protein A 70 kDa DNA-binding subunit OS Xenopus laevis GN rpa1 PE 1 SV 1
rpsblast_cdd gnl|CDD|161961 5 516 + 512 Gaps:111 69.24 608 39.90 1e-101 TIGR00617 rpa1 replication factor-a protein 1 (rpa1). All proteins in this family for which functions are known are part of a multiprotein complex made up of homologs of RPA1 RPA2 and RPA3 that bind ssDNA and function in the recognition of DNA damage for nucleotide excision repairThis family is based on the phylogenomic analysis of JA Eisen (1999 Ph.D. Thesis Stanford University).
rpsblast_cdd gnl|CDD|72946 270 368 + 99 Gaps:5 100.00 104 51.92 1e-32 cd04474 RPA1_DBD_A RPA1_DBD_A: A subfamily of OB folds corresponding to the second OB fold the ssDNA-binding domain (DBD)-A of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears to be involved in all aspects of DNA metabolism including replication recombination and repair. RPA also mediates specific interactions of various nuclear proteins. In animals plants and fungi RPA is a heterotrimer with subunits of 70KDa (RPA1) 32kDa (RPA2) and 14 KDa (RPA3). In addition to DBD-A RPA1 contains three other OB folds: DBD-B DBD-C and RPA1N. The major DNA binding activity of human RPA (hRPA) and Saccharomyces cerevisiae RPA (ScRPA) is associated with DBD-A and DBD-B of RPA1. RPA1 DBD-C is involved in trimerization. The ssDNA-binding mechanism is believed to be multistep and to involve conformational change. Although ScRPA and the hRPA have similar ssDNA-binding properties they differ functionally. Antibodies to hRPA do not cross-react with ScRPA and null mutations in the ScRPA subunits are not complemented by corresponding human genes. Also ScRPA cannot support Simian virus 40 (SV40) DNA replication in vitro whereas human RPA can..
rpsblast_cdd gnl|CDD|72947 397 504 + 108 Gaps:9 100.00 101 47.52 8e-26 cd04475 RPA1_DBD_B RPA1_DBD_B: A subfamily of OB folds corresponding to the third OB fold the ssDNA-binding domain (DBD)-B of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears to be involved in all aspects of DNA metabolism including replication recombination and repair. RPA also mediates specific interactions of various nuclear proteins. In animals plants and fungi RPA is a heterotrimer with subunits of 70KDa (RPA1) 32kDa (RPA2) and 14 KDa (RPA3). In addition to DBD-B RPA1 contains three other OB folds: DBD-A DBD-C and RPA1N. The major DNA binding activity of human RPA (hRPA) and Saccharomyces cerevisiae RPA (ScRPA) is associated with RPA1 DBD-A and DBD-B. RPA1 DBD-C is involved in trimerization. The ssDNA binding mechanism is believed to be multistep and to involve conformational change. Although ScRPA and the hRPA have similar ssDNA-binding properties they differ functionally. Antibodies to hRPA do not cross-react with ScRPA and null mutations in the ScRPA subunits are not complemented by corresponding human genes. Also ScRPA cannot support Simian virus 40 (SV40) DNA replication in vitro whereas human RPA can..
rpsblast_cdd gnl|CDD|72949 8 113 + 106 Gaps:9 100.00 97 43.30 4e-19 cd04477 RPA1N RPA1N: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears to be involved in all aspects of DNA metabolism including replication recombination and repair. RPA also mediates specific interactions of various nuclear proteins. In animals plants and fungi RPA is a heterotrimer with subunits of 70KDa (RPA1) 32kDa (RPA2) and 14 KDa (RPA3). RPA1N is known to specifically interact with the p53 tumor suppressor DNA polymerase alpha and transcription factors. In addition to RPA1N RPA1 contains three other OB folds: ssDNA-binding domain (DBD)-A DBD-B and DBD-C..

12 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Gene3D 379 509 131 G3DSA:2.40.50.140 none none IPR012340
SUPERFAMILY 381 510 130 SSF50249 none none IPR012340
Gene3D 1 124 124 G3DSA:2.40.50.140 none none IPR012340
Pfam 5 112 108 PF04057 none Replication factor-A protein 1, N-terminal domain IPR007199
PANTHER 1 173 173 PTHR23273 none none none
PANTHER 249 515 267 PTHR23273 none none none
SUPERFAMILY 274 376 103 SSF50249 none none IPR012340
PANTHER 1 173 173 PTHR23273:SF0 none none none
PANTHER 249 515 267 PTHR23273:SF0 none none none
SUPERFAMILY 1 120 120 SSF50249 none none IPR012340
Gene3D 275 367 93 G3DSA:2.40.50.140 none none IPR012340
Pfam 276 348 73 PF01336 none OB-fold nucleic acid binding domain IPR004365

0 Localization

0 Qtllist

0 Targeting