| Analysis | rpsblast_cdd | Start | 397 |
| End | 504 | Strand | + |
| Length | 108 | Note | Gaps:9 |
| Hit Coverage | 100.00 | Hit Length | 101 |
| Hit Pident | 47.52 | E Val | 8e-26 |
| Hit Description | cd04475 RPA1_DBD_B RPA1_DBD_B: A subfamily of OB folds corresponding to the third OB fold the ssDNA-binding domain (DBD)-B of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears to be involved in all aspects of DNA metabolism including replication recombination and repair. RPA also mediates specific interactions of various nuclear proteins. In animals plants and fungi RPA is a heterotrimer with subunits of 70KDa (RPA1) 32kDa (RPA2) and 14 KDa (RPA3). In addition to DBD-B RPA1 contains three other OB folds: DBD-A DBD-C and RPA1N. The major DNA binding activity of human RPA (hRPA) and Saccharomyces cerevisiae RPA (ScRPA) is associated with RPA1 DBD-A and DBD-B. RPA1 DBD-C is involved in trimerization. The ssDNA binding mechanism is believed to be multistep and to involve conformational change. Although ScRPA and the hRPA have similar ssDNA-binding properties they differ functionally. Antibodies to hRPA do not cross-react with ScRPA and null mutations in the ScRPA subunits are not complemented by corresponding human genes. Also ScRPA cannot support Simian virus 40 (SV40) DNA replication in vitro whereas human RPA can.. | Hit Pcons | 16.83 |
| Name | Qrob_P0050350.2 |
| Protein Identifier |
Organism . Name |
Score | Score Type | Protein Description | Alias (in v1) | Code Enzyme | Gene Prediction Quality |
|---|---|---|---|---|---|---|---|
| Qrob_P0050350.2 | Quercus robur | 25.0 | egn | (M=2) PTHR23273//PTHR23273:SF0 - REPLICATION FACTOR A 1, RFA1 // SUBFAMILY NOT NAMED | validated |
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