Protein : Qrob_P0038400.2 Q. robur
Protein Identifier  ? Qrob_P0038400.2 Organism . Name  Quercus robur
Score  0.0 Score Type  egn
Protein Description  (M=2) K18740 - exonuclease 3'-5' domain-containing protein 1 Gene Prediction Quality  validated
Protein length 

Sequence

Length: 215  
Kegg Orthology  K18740
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0 Synonyms

3 GO Terms

Identifier Name Description
GO:0003676 nucleic acid binding Interacting selectively and non-covalently with any nucleic acid.
GO:0006139 nucleobase-containing compound metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
GO:0008408 3'-5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.

20 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|vvi:100259526 63 206 + 144 Gaps:7 40.76 341 77.70 1e-66 uncharacterized LOC100259526
blastp_kegg lcl|mdm:103424808 69 205 + 137 Gaps:4 84.18 158 77.44 1e-66 exonuclease 3'-5' domain-containing protein 1-like
blastp_kegg lcl|rcu:RCOM_0798510 78 206 + 129 none 37.72 342 75.97 1e-66 3'-5' exonuclease putative
blastp_kegg lcl|pmum:103320522 69 206 + 138 Gaps:4 39.07 343 76.87 5e-65 exosome component 10
blastp_kegg lcl|pper:PRUPE_ppa008192mg 69 206 + 138 Gaps:4 39.18 342 76.87 3e-64 hypothetical protein
blastp_kegg lcl|mdm:103421107 85 206 + 122 none 56.48 216 78.69 1e-62 exonuclease 3'-5' domain-containing protein 1-like
blastp_kegg lcl|pxb:103929643 69 206 + 138 Gaps:4 39.07 343 74.63 3e-62 uncharacterized LOC103929643
blastp_kegg lcl|fve:101300876 70 206 + 137 Gaps:1 40.24 338 72.06 4e-62 ribonuclease D-like
blastp_kegg lcl|mdm:103410690 85 206 + 122 none 35.57 343 78.69 2e-61 uncharacterized LOC103410690
blastp_kegg lcl|pxb:103951793 69 206 + 138 Gaps:4 39.18 342 73.88 2e-61 uncharacterized LOC103951793
blastp_uniprot_sprot sp|Q8CDF7|EXD1_MOUSE 119 211 + 93 Gaps:10 18.07 570 37.86 6e-12 Exonuclease 3'-5' domain-containing protein 1 OS Mus musculus GN Exd1 PE 2 SV 1
blastp_uniprot_sprot sp|Q6NRD5|EXD1_XENLA 119 210 + 92 Gaps:1 20.95 444 37.63 5e-11 Exonuclease 3'-5' domain-containing protein 1 OS Xenopus laevis GN exd1 PE 2 SV 1
blastp_uniprot_sprot sp|Q8NHP7|EXD1_HUMAN 119 206 + 88 Gaps:1 17.32 514 39.33 5e-11 Exonuclease 3'-5' domain-containing protein 1 OS Homo sapiens GN EXD1 PE 2 SV 4
blastp_uniprot_sprot sp|Q0P3U3|EXD1_DANRE 119 211 + 93 Gaps:10 27.25 378 33.98 3e-06 Exonuclease 3'-5' domain-containing protein 1 OS Danio rerio GN exd1 PE 2 SV 1
rpsblast_cdd gnl|CDD|99851 113 213 + 101 Gaps:3 51.78 197 48.04 7e-33 cd06148 Egl_like_exo DEDDy 3'-5' exonuclease domain of Drosophila Egalitarian (Egl) and similar proteins. The Egalitarian (Egl) protein subfamily is composed of Drosophila Egl and similar proteins. Egl is a component of an mRNA-binding complex which is required for oocyte specification. Egl contains a DEDDy-type DnaQ-like 3'-5' exonuclease domain possessing three conserved sequence motifs termed ExoI ExoII and ExoIII with a specific YX(3)D pattern at ExoIII. The motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. The conservation of this subfamily throughout eukaryotes suggests that its members may be part of ancient RNA processing complexes that are likely to participate in the regulated processing of specific mRNAs. Some members of this subfamily do not have a completely conserved YX(3)D pattern at the ExoIII motif.
rpsblast_cdd gnl|CDD|28891 123 210 + 88 Gaps:1 57.42 155 30.34 9e-13 cd00007 35EXOc 3'-5' exonuclease. The 35EXOc domain is responsible for the 3'-5' exonuclease proofreading activity of prokaryotic DNA polymerase I (pol I) and other enzymes it catalyses the hydrolysis of unpaired or mismatched nucleotides. This domain consists of the amino-terminal half of the Klenow fragment in E. coli pol I. 35EXOc is also found in the Werner syndrome helicase (WRN) focus forming activity 1 protein (FFA-1) and ribonuclease D (RNase D)..
rpsblast_cdd gnl|CDD|197748 100 214 + 115 Gaps:5 66.28 172 30.70 2e-12 smart00474 35EXOc 3'-5' exonuclease. 3\' -5' exonuclease proofreading domain present in DNA polymerase I Werner syndrome helicase RNase D and other enzymes.
rpsblast_cdd gnl|CDD|201888 100 210 + 111 Gaps:6 64.53 172 32.43 1e-11 pfam01612 DNA_pol_A_exo1 3'-5' exonuclease. This domain is responsible for the 3'-5' exonuclease proofreading activity of E. coli DNA polymerase I (polI) and other enzymes it catalyzes the hydrolysis of unpaired or mismatched nucleotides. This domain consists of the amino-terminal half of the Klenow fragment in E. coli polI it is also found in the Werner syndrome helicase (WRN) focus forming activity 1 protein (FFA-1) and ribonuclease D (RNase D). Werner syndrome is a human genetic disorder causing premature aging the WRN protein has helicase activity in the 3'-5' direction. The FFA-1 protein is required for formation of a replication foci and also has helicase activity it is a homologue of the WRN protein. RNase D is a 3'-5' exonuclease involved in tRNA processing. Also found in this family is the autoantigen PM/Scl thought to be involved in polymyositis-scleroderma overlap syndrome.
rpsblast_cdd gnl|CDD|176654 123 210 + 88 Gaps:3 48.88 178 33.33 1e-08 cd06142 RNaseD_exo DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins. Ribonuclease (RNase) D is a bacterial enzyme involved in the maturation of small stable RNAs and the 3' maturation of tRNA. It contains a DEDDy-type DnaQ-like 3'-5' exonuclease domain possessing three conserved sequence motifs termed ExoI ExoII and ExoIII with a specific YX(3)D pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. In vivo RNase D only becomes essential upon removal of other ribonucleases. Eukaryotic RNase D homologs include yeast Rrp6p human PM/Scl-100 and the Drosophila melanogaster egalitarian protein.
rpsblast_kog gnl|CDD|37616 101 206 + 106 Gaps:8 40.39 458 32.43 2e-11 KOG2405 KOG2405 KOG2405 Predicted 3'-5' exonuclease [Replication recombination and repair].

4 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
SUPERFAMILY 75 211 137 SSF53098 none none IPR012337
Gene3D 119 210 92 G3DSA:3.30.420.10 none none IPR012337
Pfam 119 210 92 PF01612 none 3'-5' exonuclease IPR002562
PANTHER 97 210 114 PTHR12124 none none none

1 Localization

Analysis Start End Length
TMHMM 21 43 22

5 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran2_2014_vSeqBC_3P Qrob_Chr10 10 s_1A6CK6_610 v_7092_29 4,28 0 23,27 lod 2,8619 7
Bourran2_2015_nEpis_3P Qrob_Chr12 12 s_1AOES6_1466 s_1B0DDG_1094 28,97 28,55 30,1 lod 3.6 8.4
Bourran2_2014_nFork*_3P Qrob_Chr06 6 v_12930_125 s_1AMZEI_909 34,28 7,43 41,48 lod 2,4044 5,5
Bourran2_2015_nP_3P Qrob_Chr12 12 v_10140_295 v_838_303 16 14,69 18,01 lod 5.1 13.7
Bourran1_2004_QTL4_peak_Bud_burst_3P Qrob_Chr04 4 s_1AHUWN_1101 s_1BRNG7_1618 30,55 0 47,55 lod 2,8 7,4

1 Targeting

Analysis Start End Length Location Reliability Signal Peptide Cut Off Mitochondrion Cut Off Network Signal Peptide Length
TargetP 1 57   Mitochondrion 3 0.072 0.737 NON-PLANT 57