Protein : Qrob_P0034940.2 Q. robur
Protein Identifier  ? Qrob_P0034940.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=1) PF03134//PF12874//PF13456 - TB2/DP1, HVA22 family // Zinc-finger of C2H2 type // Reverse transcriptase-like Gene Prediction Quality  validated
Protein length 

Sequence

Length: 405  
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0 Synonyms

2 GO Terms

Identifier Name Description
GO:0003676 nucleic acid binding Interacting selectively and non-covalently with any nucleic acid.
GO:0004523 RNA-DNA hybrid ribonuclease activity Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters.

28 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|fve:101302388 1 403 + 403 Gaps:25 99.76 425 57.78 9e-162 uncharacterized protein LOC101302388
blastp_kegg lcl|pper:PRUPE_ppa018732mg 13 403 + 391 Gaps:60 96.98 430 57.07 3e-153 hypothetical protein
blastp_kegg lcl|tcc:TCM_034538 5 403 + 399 Gaps:15 98.57 420 56.28 3e-153 HVA22-like protein a putative isoform 1
blastp_kegg lcl|vvi:100264337 1 403 + 403 Gaps:27 99.77 431 54.19 2e-142 uncharacterized LOC100264337
blastp_kegg lcl|rcu:RCOM_0482840 10 403 + 394 Gaps:26 94.74 437 55.80 2e-142 hypothetical protein
blastp_kegg lcl|pop:POPTR_0005s19515g 1 403 + 403 Gaps:24 99.76 424 53.90 5e-141 POPTRDRAFT_558978 hypothetical protein
blastp_kegg lcl|pmum:103319525 62 403 + 342 Gaps:44 97.71 393 55.73 2e-140 uncharacterized LOC103319525
blastp_kegg lcl|pvu:PHAVU_008G183100g 1 403 + 403 Gaps:37 99.77 439 47.72 1e-118 hypothetical protein
blastp_kegg lcl|gmx:102661917 1 403 + 403 Gaps:82 99.79 470 44.14 1e-115 uncharacterized LOC102661917
blastp_kegg lcl|cam:101492718 6 368 + 363 Gaps:27 98.13 375 51.09 7e-109 uncharacterized LOC101492718
blastp_uniprot_sprot sp|Q9S7V4|HA22A_ARATH 20 108 + 89 Gaps:1 50.85 177 47.78 8e-20 HVA22-like protein a OS Arabidopsis thaliana GN HVA22A PE 2 SV 1
blastp_uniprot_sprot sp|Q9S784|HA22C_ARATH 20 99 + 80 none 43.48 184 43.75 2e-14 HVA22-like protein c OS Arabidopsis thaliana GN HVA22C PE 2 SV 1
blastp_uniprot_sprot sp|Q682H0|HA22F_ARATH 14 95 + 82 none 51.90 158 41.46 7e-14 HVA22-like protein f OS Arabidopsis thaliana GN HVA22F PE 2 SV 1
blastp_uniprot_sprot sp|Q9SYX7|HA22B_ARATH 20 109 + 90 Gaps:1 54.49 167 40.66 8e-14 HVA22-like protein b OS Arabidopsis thaliana GN HVA22B PE 2 SV 2
blastp_uniprot_sprot sp|Q9FED2|HA22E_ARATH 20 91 + 72 none 62.07 116 40.28 1e-08 HVA22-like protein e OS Arabidopsis thaliana GN HVA22E PE 2 SV 1
blastp_uniprot_sprot sp|Q6CP93|YOP1_KLULA 20 94 + 75 none 41.67 180 37.33 4e-08 Protein YOP1 OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) GN YOP1 PE 3 SV 1
blastp_uniprot_sprot sp|P0C2F6|RNHX1_ARATH 237 371 + 135 Gaps:12 22.10 620 35.77 6e-08 Putative ribonuclease H protein At1g65750 OS Arabidopsis thaliana GN At1g65750 PE 3 SV 1
blastp_uniprot_sprot sp|Q9S760|HA22D_ARATH 14 87 + 74 none 54.81 135 35.14 3e-07 HVA22-like protein d OS Arabidopsis thaliana GN HVA22D PE 2 SV 1
blastp_uniprot_sprot sp|Q9UU91|YOP1_SCHPO 1 128 + 128 Gaps:5 69.78 182 29.13 5e-06 Protein yop1 OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN yop1 PE 1 SV 1
blastp_uniprot_sprot sp|Q07764|HVA22_HORVU 20 87 + 68 none 52.31 130 38.24 5e-06 Protein HVA22 OS Hordeum vulgare GN HVA22 PE 2 SV 1
rpsblast_cdd gnl|CDD|187690 252 371 + 120 Gaps:2 99.19 123 37.70 3e-24 cd06222 RNase_H RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner. Ribonuclease H (RNase H) enzymes are divided into two major families Type 1 and Type 2 based on amino acid sequence similarities and biochemical properties. RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner in the presence of divalent cations. RNase H is widely present in various organisms including bacteria archaea and eukaryotes. Most prokaryotic and eukaryotic genomes contain multiple RNase H genes. Despite the lack of amino acid sequence homology Type 1 and type 2 RNase H share a main-chain fold and steric configurations of the four acidic active-site residues and have the same catalytic mechanism and functions in cells. RNase H is involved in DNA replication repair and transcription. One of the important functions of RNase H is to remove Okazaki fragments during DNA replication. RNase H inhibitors have been explored as an anti-HIV drug target because RNase H inactivation inhibits reverse transcription.
rpsblast_cdd gnl|CDD|205634 291 371 + 81 none 92.05 88 45.68 4e-19 pfam13456 RVT_3 Reverse transcriptase-like. This domain is found in plants and appears to be part of a retrotransposon.
rpsblast_cdd gnl|CDD|190535 20 95 + 76 none 80.85 94 39.47 7e-15 pfam03134 TB2_DP1_HVA22 TB2/DP1 HVA22 family. This family includes members from a wide variety of eukaryotes. It includes the TB2/DP1 (deleted in polyposis) protein which in humans is deleted in severe forms of familial adenomatous polyposis an autosomal dominant oncological inherited disease. The family also includes the plant protein of known similarity to TB2/DP1 the HVA22 abscisic acid-induced protein which is thought to be a regulatory protein.
rpsblast_cdd gnl|CDD|187703 250 371 + 122 Gaps:3 97.66 128 28.00 2e-09 cd09279 RNase_HI_archaeal_like RNAse HI family that includes Archaeal RNase HI. Ribonuclease H (RNase H) is classified into two evolutionarily unrelated families type 1 (prokaryotic RNase HI eukaryotic RNase H1 and viral RNase H) and type 2 (prokaryotic RNase HII and HIII and eukaryotic RNase H2). RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner. RNase H is involved in DNA replication repair and transcription. RNase H is widely present in various organisms including bacteria archaea and eukaryotes and most prokaryotic and eukaryotic genomes contain multiple RNase H genes. Despite the lack of amino acid sequence homology Type 1 and type 2 RNase H share a main-chain fold and steric configurations of the four acidic active-site (DEDD) residues and have the same catalytic mechanism and functions in cells. One of the important functions of RNase H is to remove Okazaki fragments during DNA replication. Most archaeal genomes contain only type 2 RNase H (RNase HII) however a few contain RNase HI as well. Although archaeal RNase HI sequences conserve the DEDD active-site motif they lack other common features important for catalytic function such as the basic protrusion region. Archaeal RNase HI homologs are more closely related to retroviral RNase HI than bacterial and eukaryotic type I RNase H in enzymatic properties.
rpsblast_cdd gnl|CDD|187700 253 372 + 120 Gaps:12 96.88 128 33.87 7e-09 cd09276 Rnase_HI_RT_non_LTR non-LTR RNase HI domain of reverse transcriptases. Ribonuclease H (RNase H) is classified into two families type 1 (prokaryotic RNase HI eukaryotic RNase H1 and viral RNase H) and type 2 (prokaryotic RNase HII and HIII and eukaryotic RNase H2). Ribonuclease HI (RNase HI) is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner. RNase H is widely present in various organisms including bacteria archaea and eukaryotes. RNase HI has also been observed as an adjunct domain to the reverse transcriptase gene in retroviruses long-term repeat (LTR)-bearing retrotransposons and non-LTR retrotransposons. RNase HI in LTR retrotransposons perform degradation of the original RNA template generation of a polypurine tract (the primer for plus-strand DNA synthesis) and final removal of RNA primers from newly synthesized minus and plus strands. The catalytic residues for RNase H enzymatic activity three aspartatic acids and one glutamatic acid residue (DEDD) are unvaried across all RNase H domains. The position of the RNase domain of non-LTR and LTR transposons is at the carboxyl terminal of the reverse transcriptase (RT) domain and their RNase domains group together indicating a common evolutionary origin. Many non-LTR transposons have lost the RNase domain because their activity is at the nucleus and cellular RNase may suffice however LTR retotransposons always encode their own RNase domain because it requires RNase activity in RNA-protein particles in the cytoplasm. RNase H inhibitors have been explored as an anti-HIV drug target because RNase H inactivation inhibits reverse transcription.
rpsblast_cdd gnl|CDD|34657 4 128 + 125 Gaps:1 67.74 186 21.43 1e-07 COG5052 YOP1 Protein involved in membrane traffic [Intracellular trafficking and secretion].
rpsblast_kog gnl|CDD|36936 2 95 + 94 Gaps:1 50.00 186 38.71 2e-14 KOG1725 KOG1725 KOG1725 Protein involved in membrane traffic (YOP1/TB2/DP1/HVA22 family) [Intracellular trafficking secretion and vesicular transport].
rpsblast_kog gnl|CDD|36937 13 218 + 206 Gaps:14 96.00 225 21.76 9e-08 KOG1726 KOG1726 KOG1726 HVA22/DP1 gene product-related proteins [Defense mechanisms].

16 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
ProSiteProfiles 245 373 129 PS50879 none RNase H domain profile. IPR002156
Phobius 38 57 20 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 1 5 5 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 88 404 317 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
PANTHER 20 110 91 PTHR12300:SF22 none none none
PANTHER 20 110 91 PTHR12300 none none IPR004345
Gene3D 251 372 122 G3DSA:3.30.420.10 none none IPR012337
Phobius 6 26 21 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 63 87 25 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
SUPERFAMILY 248 378 131 SSF53098 none none IPR012337
Pfam 169 193 25 PF12874 none Zinc-finger of C2H2 type none
Pfam 12 94 83 PF03134 none TB2/DP1, HVA22 family IPR004345
Phobius 58 62 5 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Pfam 291 372 82 PF13456 none Reverse transcriptase-like none
Phobius 27 37 11 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
SUPERFAMILY 153 197 45 SSF57667 none none none

4 Localization

Analysis Start End Length
TMHMM 70 92 22
TMHMM 38 55 17
TMHMM 4 26 22
SignalP_EUK 1 25 24

0 Qtllist

1 Targeting

Analysis Start End Length Location Reliability Signal Peptide Cut Off Mitochondrion Cut Off Network Signal Peptide Length
TargetP 1 25   Secretory pathway 1 0.964 0.035 NON-PLANT 25