| Analysis | rpsblast_cdd | Start | 253 |
| End | 372 | Strand | + |
| Length | 120 | Note | Gaps:12 |
| Hit Coverage | 96.88 | Hit Length | 128 |
| Hit Pident | 33.87 | E Val | 7e-09 |
| Hit Description | cd09276 Rnase_HI_RT_non_LTR non-LTR RNase HI domain of reverse transcriptases. Ribonuclease H (RNase H) is classified into two families type 1 (prokaryotic RNase HI eukaryotic RNase H1 and viral RNase H) and type 2 (prokaryotic RNase HII and HIII and eukaryotic RNase H2). Ribonuclease HI (RNase HI) is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner. RNase H is widely present in various organisms including bacteria archaea and eukaryotes. RNase HI has also been observed as an adjunct domain to the reverse transcriptase gene in retroviruses long-term repeat (LTR)-bearing retrotransposons and non-LTR retrotransposons. RNase HI in LTR retrotransposons perform degradation of the original RNA template generation of a polypurine tract (the primer for plus-strand DNA synthesis) and final removal of RNA primers from newly synthesized minus and plus strands. The catalytic residues for RNase H enzymatic activity three aspartatic acids and one glutamatic acid residue (DEDD) are unvaried across all RNase H domains. The position of the RNase domain of non-LTR and LTR transposons is at the carboxyl terminal of the reverse transcriptase (RT) domain and their RNase domains group together indicating a common evolutionary origin. Many non-LTR transposons have lost the RNase domain because their activity is at the nucleus and cellular RNase may suffice however LTR retotransposons always encode their own RNase domain because it requires RNase activity in RNA-protein particles in the cytoplasm. RNase H inhibitors have been explored as an anti-HIV drug target because RNase H inactivation inhibits reverse transcription. | Hit Pcons | 8.87 |
| Name | Qrob_P0034940.2 |
| Protein Identifier |
Organism . Name |
Score | Score Type | Protein Description | Alias (in v1) | Code Enzyme | Gene Prediction Quality |
|---|---|---|---|---|---|---|---|
| Qrob_P0034940.2 | Quercus robur | 100.0 | egn | (M=1) PF03134//PF12874//PF13456 - TB2/DP1, HVA22 family // Zinc-finger of C2H2 type // Reverse transcriptase-like | validated |
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