Protein : Qrob_P0010570.2 Q. robur
Protein Identifier  ? Qrob_P0010570.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=1) K08873 - PI-3-kinase-related kinase SMG-1 Code Enzyme  EC:2.7.11.1
Gene Prediction Quality  validated Protein length 

Sequence

Length: 3925  
Kegg Orthology  K08873
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0 Synonyms

3 GO Terms

Identifier Name Description
GO:0005515 protein binding Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
GO:0005488 binding The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
GO:0016773 phosphotransferase activity, alcohol group as acceptor Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor).

37 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|pper:PRUPE_ppa000007mg 13 3819 + 3807 Gaps:53 99.53 3792 76.66 0.0 hypothetical protein
blastp_kegg lcl|pmum:103335454 13 3819 + 3807 Gaps:53 99.53 3792 76.66 0.0 serine/threonine-protein kinase SMG1-like
blastp_kegg lcl|vvi:100260579 13 3819 + 3807 Gaps:49 99.55 3787 76.71 0.0 SMG1 smg-1 homolog phosphatidylinositol 3-kinase-related kinase (C. elegans)
blastp_kegg lcl|mdm:103402261 13 3819 + 3807 Gaps:69 99.55 3789 75.90 0.0 uncharacterized LOC103402261
blastp_kegg lcl|pxb:103934403 13 3819 + 3807 Gaps:62 99.55 3782 75.62 0.0 uncharacterized LOC103934403
blastp_kegg lcl|cit:102618809 13 3819 + 3807 Gaps:38 99.53 3821 75.07 0.0 uncharacterized LOC102618809
blastp_kegg lcl|cic:CICLE_v10027657mg 13 3819 + 3807 Gaps:51 99.53 3800 75.25 0.0 hypothetical protein
blastp_kegg lcl|fve:101291497 3 3819 + 3817 Gaps:68 99.81 3778 74.17 0.0 uncharacterized protein LOC101291497
blastp_kegg lcl|tcc:TCM_006288 13 3819 + 3807 Gaps:42 99.53 3831 74.27 0.0 Target of rapamycin
blastp_kegg lcl|pop:POPTR_0004s15490g 50 3819 + 3770 Gaps:69 98.44 3788 73.59 0.0 hypothetical protein
blastp_uniprot_sprot sp|Q8BKX6|SMG1_MOUSE 50 3819 + 3770 Gaps:372 54.51 3658 30.74 1e-164 Serine/threonine-protein kinase SMG1 OS Mus musculus GN Smg1 PE 1 SV 3
blastp_uniprot_sprot sp|Q96Q15|SMG1_HUMAN 50 3819 + 3770 Gaps:374 53.48 3661 30.95 6e-161 Serine/threonine-protein kinase SMG1 OS Homo sapiens GN SMG1 PE 1 SV 3
blastp_uniprot_sprot sp|Q70PP2|SMG1_DROME 873 3819 + 2947 Gaps:150 35.86 3218 34.49 7e-107 Serine/threonine-protein kinase Smg1 OS Drosophila melanogaster GN nonC PE 1 SV 2
blastp_uniprot_sprot sp|O01510|SMG1_CAEEL 873 2350 + 1478 Gaps:92 34.93 2322 33.79 2e-103 Serine/threonine-protein kinase smg-1 OS Caenorhabditis elegans GN smg-1 PE 1 SV 3
blastp_uniprot_sprot sp|Q553E9|SMG1_DICDI 872 2324 + 1453 Gaps:180 42.11 2344 32.42 1e-99 Probable serine/threonine-protein kinase smg1 OS Dictyostelium discoideum GN smg1 PE 3 SV 1
blastp_uniprot_sprot sp|Q61CW2|SMG1_CAEBR 1661 2350 + 690 Gaps:73 29.18 2313 33.78 2e-99 Serine/threonine-protein kinase smg-1 OS Caenorhabditis briggsae GN smg-1 PE 3 SV 3
blastp_uniprot_sprot sp|Q9FR53|TOR_ARATH 1722 2327 + 606 Gaps:86 21.85 2481 34.13 2e-63 Serine/threonine-protein kinase TOR OS Arabidopsis thaliana GN TOR PE 1 SV 1
blastp_uniprot_sprot sp|Q9VK45|TOR_DROME 1722 2320 + 599 Gaps:90 21.50 2470 33.52 3e-63 Target of rapamycin OS Drosophila melanogaster GN Tor PE 1 SV 1
blastp_uniprot_sprot sp|Q86C65|TOR_DICDI 1722 2320 + 599 Gaps:84 22.31 2380 33.33 6e-63 Target of rapamycin OS Dictyostelium discoideum GN tor PE 1 SV 1
blastp_uniprot_sprot sp|Q0DJS1|TOR_ORYSJ 1722 2341 + 620 Gaps:102 22.88 2465 33.33 2e-62 Serine/threonine-protein kinase TOR OS Oryza sativa subsp. japonica GN TOR PE 2 SV 3
rpsblast_cdd gnl|CDD|119430 2016 2322 + 307 none 100.00 307 54.40 1e-137 cd05170 PIKKc_SMG1 Suppressor of morphogenetic effect on genitalia-1 (SMG-1) catalytic domain The SMG-1 catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs) aminoglycoside phosphotransferase choline kinase and RIO kinases. SMG-1 is a member of the phosphoinositide 3-kinase-related protein kinase (PIKK) subfamily. PIKKs have intrinsic serine/threonine kinase activity and are distinguished from other PKs by their unique catalytic domain similar to that of lipid PI3K and their large molecular weight (240-470 kDa). In addition to its catalytic domain SMG-1 contains a FATC (FRAP ATM and TRRAP C-terminal) domain at the C-terminus. SMG-1 plays a critical role in the mRNA surveillance mechanism known as non-sense mediated mRNA decay (NMD). NMD protects the cells from the accumulation of aberrant mRNAs with premature termination codons (PTCs) generated by genome mutations and by errors during transcription and splicing. SMG-1 phosphorylates Upf1 another central component of NMD at the C-terminus upon recognition of PTCs. The phosphorylation/dephosphorylation cycle of Upf1 is essential for promoting NMD..
rpsblast_cdd gnl|CDD|119429 2016 2321 + 306 Gaps:45 99.64 280 43.73 8e-76 cd05169 PIKKc_TOR TOR (Target of rapamycin) catalytic domain The TOR catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs) aminoglycoside phosphotransferase choline kinase and RIO kinases. TOR is a member of the phosphoinositide 3-kinase-related protein kinase (PIKK) subfamily. PIKKs have intrinsic serine/threonine kinase activity and are distinguished from other PKs by their unique catalytic domain similar to that of lipid PI3K and their large molecular weight (240-470 kDa). TOR contains a rapamycin binding domain a catalytic domain and a FATC (FRAP ATM and TRRAP C-terminal) domain at the C-terminus. It is also called FRAP (FK506 binding protein 12-rapamycin associated protein). TOR is a central component of the eukaryotic growth regulatory network. It controls the expression of many genes transcribed by all three RNA polymerases. It associates with other proteins to form two distinct complexes TORC1 and TORC2. TORC1 is involved in diverse growth-related functions including protein synthesis nutrient use and transport autophagy and stress responses. TORC2 is involved in organizing cytoskeletal structures..
rpsblast_cdd gnl|CDD|119431 2016 2321 + 306 Gaps:34 99.64 279 39.93 1e-65 cd05171 PIKKc_ATM Ataxia telangiectasia mutated (ATM) catalytic domain The ATM catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs) aminoglycoside phosphotransferase choline kinase and RIO kinases. ATM is a member of the phosphoinositide 3-kinase-related protein kinase (PIKK) subfamily. PIKKs have intrinsic serine/threonine kinase activity and are distinguished from other PKs by their unique catalytic domain similar to that of lipid PI3K and their large molecular weight (240-470 kDa). ATM contains a FAT (FRAP ATM and TRRAP) domain a catalytic domain and a FATC domain at the C-terminus. ATM is critical in the response to DNA double strand breaks (DSBs) caused by radiation. It is activated at the site of a DSB and phosphorylates key substrates that trigger pathways that regulate DNA repair and cell cycle checkpoints at the G1/S S phase and G2/M transition. Patients with the human genetic disorder Ataxia telangiectasia (A-T) caused by truncating mutations in ATM show genome instability increased cancer risk immunodeficiency compromised mobility and neurodegeneration. A-T displays clinical heterogeneity which is correlated to the degree of retained ATM activity..
rpsblast_cdd gnl|CDD|34637 1754 2322 + 569 Gaps:81 23.66 2105 27.51 3e-53 COG5032 TEL1 Phosphatidylinositol kinase and protein kinases of the PI-3 kinase family [Signal transduction mechanisms / Cell division and chromosome partitioning / Chromatin structure and dynamics / DNA replication recombination and repair / Intracellular trafficking and secretion].
rpsblast_cdd gnl|CDD|119418 2016 2322 + 307 Gaps:9 95.36 237 47.35 8e-45 cd00892 PIKKc_ATR ATR (Ataxia telangiectasia and Rad3-related) catalytic domain The ATR catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs) aminoglycoside phosphotransferase choline kinase and RIO kinases. ATR is also referred to as Mei-41 (Drosophila) Esr1/Mec1p (Saccharomyces cerevisiae) Rad3 (Schizosaccharomyces pombe) and FRAP-related protein (human). ATR is a member of the phosphoinositide 3-kinase-related protein kinase (PIKK) subfamily. PIKKs have intrinsic serine/threonine kinase activity and are distinguished from other PKs by their unique catalytic domain similar to that of lipid PI3K and their large molecular weight (240-470 kDa). ATR contains a UME domain of unknown function a FAT (FRAP ATM and TRRAP) domain a catalytic domain and a FATC domain at the C-terminus. Together with its downstream effector kinase Chk1 ATR plays a central role in regulating the replication checkpoint. ATR stabilizes replication forks by promoting the association of DNA polymerases with the fork. Preventing fork collapse is essential in preserving genomic integrity. ATR plays a role in normal cell growth and in response to DNA damage..
rpsblast_cdd gnl|CDD|197542 2048 2324 + 277 Gaps:42 99.58 240 33.89 1e-44 smart00146 PI3Kc Phosphoinositide 3-kinase catalytic domain. Phosphoinositide 3-kinase isoforms participate in a variety of processes including cell motility the Ras pathway vesicle trafficking and secretion and apoptosis. These homologues may be either lipid kinases and/or protein kinases: the former phosphorylate the 3-position in the inositol ring of inositol phospholipids. The ataxia telangiectesia-mutated gene produced the targets of rapamycin (TOR) and the DNA-dependent kinase have not been found to possess lipid kinase activity. Some of this family possess PI-4 kinase activities.
rpsblast_cdd gnl|CDD|189554 2045 2322 + 278 Gaps:52 99.57 233 34.48 2e-41 pfam00454 PI3_PI4_kinase Phosphatidylinositol 3- and 4-kinase. Some members of this family probably do not have lipid kinase activity and are protein kinases .
rpsblast_cdd gnl|CDD|119424 2016 2315 + 300 none 100.00 222 51.35 1e-37 cd05164 PIKKc Phosphoinositide 3-kinase-related protein kinase (PIKK) subfamily catalytic domain The PIKK catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs) aminoglycoside phosphotransferase choline kinase and RIO kinases. Members include ATM (Ataxia telangiectasia mutated) ATR (Ataxia telangiectasia and Rad3-related) TOR (Target of rapamycin) SMG-1 (Suppressor of morphogenetic effect on genitalia-1) and DNA-PK (DNA-dependent protein kinase). PIKKs have intrinsic serine/threonine kinase activity and are distinguished from other PKs by their unique catalytic domain similar to that of lipid PI3K and their large molecular weight (240-470 kDa). They show strong preference for phosphorylating serine/threonine residues followed by a glutamine and are also referred to as (S/T)-Q-directed kinases. They all contain a FATC (FRAP ATM and TRRAP C-terminal) domain. PIKKs have diverse functions including cell-cycle checkpoints genome surveillance mRNA surveillance and translation control..
rpsblast_cdd gnl|CDD|119416 2016 2315 + 300 Gaps:3 100.00 219 37.44 2e-29 cd00142 PI3Kc_like Phosphoinositide 3-kinase (PI3K)-like family catalytic domain The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs) aminoglycoside phosphotransferase choline kinase and RIO kinases. Members of the family include PI3K phosphoinositide 4-kinase (PI4K) PI3K-related protein kinases (PIKKs) and TRansformation/tRanscription domain-Associated Protein (TRRAP). PI3Ks catalyze the transfer of the gamma-phosphoryl group from ATP to the 3-hydroxyl of the inositol ring of D-myo-phosphatidylinositol (PtdIns) or its derivatives while PI4K catalyze the phosphorylation of the 4-hydroxyl of PtdIns. PIKKs are protein kinases that catalyze the phosphorylation of serine/threonine residues especially those that are followed by a glutamine. PI3Ks play an important role in a variety of fundamental cellular processes including cell motility the Ras pathway vesicle trafficking and secretion immune cell activation and apoptosis. PI4Ks produce PtdIns(4)P the major precursor to important signaling phosphoinositides. PIKKs have diverse functions including cell-cycle checkpoints genome surveillance mRNA surveillance and translation control..
rpsblast_cdd gnl|CDD|119432 2016 2322 + 307 Gaps:4 100.00 235 38.72 5e-24 cd05172 PIKKc_DNA-PK DNA-dependent protein kinase (DNA-PK) catalytic domain The DNA-PK catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs) aminoglycoside phosphotransferase choline kinase and RIO kinases. DNA-PK is a member of the phosphoinositide 3-kinase-related protein kinase (PIKK) subfamily. PIKKs have intrinsic serine/threonine kinase activity and are distinguished from other PKs by their unique catalytic domain similar to that of lipid PI3K and their large molecular weight (240-470 kDa). DNA-PK is comprised of a regulatory subunit containing the Ku70/80 subunit and a catalytic subunit which contains a NUC194 domain of unknown function a FAT (FRAP ATM and TRRAP) domain a catalytic domain and a FATC domain at the C-terminus. It is part of a multi-component system involved in non-homologous end joining (NHEJ) a process of repairing double strand breaks (DSBs) by joining together two free DNA ends of little homology. DNA-PK functions as a molecular sensor for DNA damage that enhances the signal via phosphorylation of downstream targets. It may also act as a protein scaffold that aids the localization of DNA repair proteins to the site of DNA damage. DNA-PK also plays a role in the maintenance of telomeric stability and the prevention of chromosomal end fusion..

35 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Gene3D 1995 2094 100 G3DSA:3.30.1010.10 none none none
SUPERFAMILY 2011 2122 112 SSF56112 none none IPR011009
SUPERFAMILY 2186 2324 139 SSF56112 none none IPR011009
Pfam 2045 2321 277 PF00454 none Phosphatidylinositol 3- and 4-kinase IPR000403
SMART 2046 2383 338 SM00146 none Phosphoinositide 3-kinase, catalytic domain IPR000403
SUPERFAMILY 272 383 112 SSF48371 none none IPR016024
SUPERFAMILY 605 756 152 SSF48371 none none IPR016024
SUPERFAMILY 1512 1584 73 SSF48371 none none IPR016024
SUPERFAMILY 457 493 37 SSF48371 none none IPR016024
SUPERFAMILY 1723 1799 77 SSF48371 none none IPR016024
SUPERFAMILY 534 554 21 SSF48371 none none IPR016024
SUPERFAMILY 1297 1383 87 SSF48371 none none IPR016024
SUPERFAMILY 1422 1446 25 SSF48371 none none IPR016024
ProSitePatterns 2215 2235 21 PS00916 none Phosphatidylinositol 3- and 4-kinases signature 2. IPR018936
Coils 2884 2905 22 Coil none none none
SUPERFAMILY 352 424 73 SSF48371 none none IPR016024
SUPERFAMILY 85 256 172 SSF48371 none none IPR016024
SUPERFAMILY 787 792 6 SSF48371 none none IPR016024
SUPERFAMILY 621 750 130 SSF48371 none none IPR016024
ProSiteProfiles 3793 3843 51 PS51190 none FATC domain profile. IPR003152
Coils 2607 2628 22 Coil none none none
PANTHER 1490 1532 43 PTHR11139 none none none
PANTHER 1651 1696 46 PTHR11139 none none none
PANTHER 1188 1453 266 PTHR11139 none none none
PANTHER 832 912 81 PTHR11139 none none none
PANTHER 3769 3819 51 PTHR11139 none none none
PANTHER 929 1013 85 PTHR11139 none none none
PANTHER 1911 2354 444 PTHR11139 none none none
PANTHER 1046 1166 121 PTHR11139 none none none
PANTHER 1718 1873 156 PTHR11139 none none none

0 Localization

5 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran2_2015_nEpis_3P Qrob_Chr12 12 s_1AOES6_1466 s_1B0DDG_1094 28,97 28,55 30,1 lod 3.6 8.4
Champenoux_2015_nEpis_3P Qrob_Chr11 11 s_1DG9PM_867 s_1BZ083_1312 26,53 25,47 27,72 lod 4.4 8.9
Bourran2_2002_QTL16_peak_Bud_burst_A4 Qrob_Chr11 11 s_A9OIA_166 s_1C6WBF_114 21,23 2,83 42,83 lod 5,1 7,2
Bourran2_2015_nSeqBC_3P Qrob_Chr11 11 s_1DG9PM_867 s_1BZ083_1312 26,06 25,47 27,72 lod 3.6 7.1
Champenoux_2015_nSecLBD_3P Qrob_Chr11 11 s_1DG9PM_867 s_1BZ083_1312 25,78 25,47 27,72 lod 6.3 16.6

1 Targeting

Analysis Start End Length Location Reliability Signal Peptide Cut Off Mitochondrion Cut Off Network Signal Peptide Length
TargetP 1 27   Secretory pathway 5 0.365 0.089 NON-PLANT 27