| Analysis | rpsblast_cdd | Start | 2016 |
| End | 2322 | Strand | + |
| Length | 307 | Note | Gaps:4 |
| Hit Coverage | 100.00 | Hit Length | 235 |
| Hit Pident | 38.72 | E Val | 5e-24 |
| Hit Description | cd05172 PIKKc_DNA-PK DNA-dependent protein kinase (DNA-PK) catalytic domain The DNA-PK catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs) aminoglycoside phosphotransferase choline kinase and RIO kinases. DNA-PK is a member of the phosphoinositide 3-kinase-related protein kinase (PIKK) subfamily. PIKKs have intrinsic serine/threonine kinase activity and are distinguished from other PKs by their unique catalytic domain similar to that of lipid PI3K and their large molecular weight (240-470 kDa). DNA-PK is comprised of a regulatory subunit containing the Ku70/80 subunit and a catalytic subunit which contains a NUC194 domain of unknown function a FAT (FRAP ATM and TRRAP) domain a catalytic domain and a FATC domain at the C-terminus. It is part of a multi-component system involved in non-homologous end joining (NHEJ) a process of repairing double strand breaks (DSBs) by joining together two free DNA ends of little homology. DNA-PK functions as a molecular sensor for DNA damage that enhances the signal via phosphorylation of downstream targets. It may also act as a protein scaffold that aids the localization of DNA repair proteins to the site of DNA damage. DNA-PK also plays a role in the maintenance of telomeric stability and the prevention of chromosomal end fusion.. | Hit Pcons | 17.87 |
| Name | Qrob_P0010570.2 |
| Protein Identifier |
Organism . Name |
Score | Score Type | Protein Description | Alias (in v1) | Code Enzyme | Gene Prediction Quality |
|---|---|---|---|---|---|---|---|
| Qrob_P0010570.2 | Quercus robur | 100.0 | egn | (M=1) K08873 - PI-3-kinase-related kinase SMG-1 | EC:2.7.11.1 | validated |
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