Protein : Qrob_P0008270.2 Q. robur
Protein Identifier  ? Qrob_P0008270.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=4) 3.2.2.20 - DNA-3-methyladenine glycosylase I. Code Enzyme  EC:3.2.2.20
Gene Prediction Quality  validated Protein length 

Sequence

Length: 211  
Kegg Orthology  K01246
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0 Synonyms

4 GO Terms

Identifier Name Description
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.
GO:0008725 DNA-3-methyladenine glycosylase activity Catalysis of the reaction: DNA containing 3-methyladenine + H2O = DNA with abasic site + 3-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methyladenine and the deoxyribose sugar to remove the 3-methyladenine, leaving an abasic site.

27 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|gmx:100805836 24 209 + 186 Gaps:41 45.36 377 59.65 6e-56 uncharacterized LOC100805836
blastp_kegg lcl|pvu:PHAVU_010G161200g 24 209 + 186 Gaps:41 45.00 380 57.31 4e-54 hypothetical protein
blastp_kegg lcl|cam:101512572 24 209 + 186 Gaps:43 46.51 372 60.12 8e-53 probable GMP synthase [glutamine-hydrolyzing]-like
blastp_kegg lcl|vvi:100267363 24 209 + 186 Gaps:43 45.07 375 58.58 1e-51 probable GMP synthase [glutamine-hydrolyzing]-like
blastp_kegg lcl|tcc:TCM_037057 25 209 + 185 Gaps:42 44.59 379 60.36 1e-51 DNA glycosylase superfamily protein isoform 1
blastp_kegg lcl|mtr:MTR_4g007070 24 209 + 186 Gaps:43 32.40 534 58.96 4e-51 DNA-3-methyladenine glycosylase I
blastp_kegg lcl|pop:POPTR_0006s19830g 17 209 + 193 Gaps:44 45.93 381 57.71 4e-51 POPTRDRAFT_802190 methyladenine glycosylase family protein
blastp_kegg lcl|rcu:RCOM_0622880 24 209 + 186 Gaps:44 44.21 380 57.14 6e-50 DNA-3-methyladenine glycosylase putative (EC:3.2.2.20)
blastp_kegg lcl|cmo:103499838 24 198 + 175 Gaps:43 43.78 370 58.64 1e-49 uncharacterized LOC103499838
blastp_kegg lcl|pop:POPTR_0018s11610g 24 209 + 186 Gaps:44 44.21 380 58.33 1e-49 POPTRDRAFT_578745 methyladenine glycosylase family protein
blastp_pdb 1p7m_A 24 162 + 139 Gaps:41 66.31 187 31.45 2e-11 mol:protein length:187 DNA-3-methyladenine glycosylase I
blastp_pdb 1nku_A 24 162 + 139 Gaps:41 66.31 187 31.45 2e-11 mol:protein length:187 3-Methyladenine Dna Glycosylase I (TAG)
blastp_pdb 1lmz_A 24 162 + 139 Gaps:41 66.31 187 31.45 2e-11 mol:protein length:187 3-methyladenine DNA glycosylase I (TAG)
blastp_pdb 2ofi_A 24 163 + 140 Gaps:41 67.93 184 28.80 2e-09 mol:protein length:184 3-methyladenine DNA glycosylase I constituti
blastp_pdb 2ofk_B 24 163 + 140 Gaps:41 68.31 183 28.80 2e-09 mol:protein length:183 3-methyladenine DNA glycosylase I constituti
blastp_pdb 2ofk_A 24 163 + 140 Gaps:41 68.31 183 28.80 2e-09 mol:protein length:183 3-methyladenine DNA glycosylase I constituti
blastp_pdb 2jg6_A 24 162 + 139 Gaps:41 66.67 186 29.03 4e-09 mol:protein length:186 DNA-3-METHYLADENINE GLYCOSIDASE
blastp_pdb 4ai4_A 24 162 + 139 Gaps:41 65.96 188 29.03 4e-09 mol:protein length:188 DNA-3-METHYLADENINE GLYCOSYLASE I
blastp_pdb 4aia_E 24 162 + 139 Gaps:41 65.96 188 29.03 4e-09 mol:protein length:188 DNA-3-METHYLADENINE GLYCOSYLASE I
blastp_pdb 4aia_D 24 162 + 139 Gaps:41 65.96 188 29.03 4e-09 mol:protein length:188 DNA-3-METHYLADENINE GLYCOSYLASE I
blastp_uniprot_sprot sp|Q7VG78|GUAA_HELHP 8 164 + 157 Gaps:45 10.62 1375 35.62 7e-13 Probable GMP synthase [glutamine-hydrolyzing] OS Helicobacter hepaticus (strain ATCC 51449 / 3B1) GN guaA PE 3 SV 1
blastp_uniprot_sprot sp|P44321|3MGA_HAEIN 24 162 + 139 Gaps:41 67.03 185 36.29 4e-11 DNA-3-methyladenine glycosylase OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) GN tag PE 3 SV 1
blastp_uniprot_sprot sp|P05100|3MG1_ECOLI 24 162 + 139 Gaps:41 66.31 187 32.26 5e-11 DNA-3-methyladenine glycosylase 1 OS Escherichia coli (strain K12) GN tag PE 1 SV 1
rpsblast_cdd gnl|CDD|190612 24 167 + 144 Gaps:41 72.07 179 35.66 1e-31 pfam03352 Adenine_glyco Methyladenine glycosylase. The DNA-3-methyladenine glycosylase I is constitutively expressed and is specific for the alkylated 3-methyladenine DNA.
rpsblast_cdd gnl|CDD|32646 24 168 + 145 Gaps:41 69.15 188 31.54 5e-16 COG2818 Tag 3-methyladenine DNA glycosylase [DNA replication recombination and repair].
rpsblast_cdd gnl|CDD|129711 23 165 + 143 Gaps:45 70.39 179 26.19 6e-13 TIGR00624 tag DNA-3-methyladenine glycosylase I. All proteins in this family are alkylation DNA glycosylases that function in base excision repair This family is based on the phylogenomic analysis of JA Eisen (1999 Ph.D. Thesis Stanford University).
rpsblast_cdd gnl|CDD|182401 24 163 + 140 Gaps:41 66.84 187 32.00 5e-11 PRK10353 PRK10353 3-methyl-adenine DNA glycosylase I Provisional.

9 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
SUPERFAMILY 98 168 71 SSF48150 "Reactome:REACT_216" none IPR011257
SUPERFAMILY 9 79 71 SSF48150 "Reactome:REACT_216" none IPR011257
Gene3D 11 165 155 G3DSA:1.10.340.30 "Reactome:REACT_216" none IPR011257
PANTHER 24 72 49 PTHR31116 none none none
PANTHER 101 205 105 PTHR31116 none none none
PANTHER 24 72 49 PTHR31116:SF1 none none none
PANTHER 101 205 105 PTHR31116:SF1 none none none
Pfam 15 82 68 PF03352 none Methyladenine glycosylase IPR005019
Pfam 98 166 69 PF03352 none Methyladenine glycosylase IPR005019

1 Localization

Analysis Start End Length
SignalP_EUK 1 20 19

7 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran2_2014_nLBD*_A4 Qrob_Chr08 8 v_12498_318 v_12364_308 34,91 16,12 53,62 lod 2,4961 5,2
Bourran2_2014_rEpiBC*_A4 Qrob_Chr08 8 v_12498_318 v_12364_308 35,77 14,11 55,31 lod 2,9413 6,2
Bourran_2000_2002_QTL6_Delta.F Qrob_Chr03 3 s_2HYXJ2_207 s_1AUAXK_317 29.12 6,3 45,37 lod 3.1666 0.026
Bourran2_2014_nLBD_3P Qrob_Chr03 3 s_1ET7H8_604 s_1BYNB5_834 23,73 0 46,72 lod 1,7573 3,8
PM_1999_QTL14_peak_Bud_burst_3P Qrob_Chr03 3 s_2F0SI1_756 v_6056_735 11,78 3,78 50,78 lod 2,5 4,5
Bourran2_2014_nPriLBD*_3P Qrob_Chr11 11 v_12066_307 s_1B15GJ_447 3,37 0,57 16,17 lod 3,4299 6,9
Bourran2_2014_rEpiBC*_3P Qrob_Chr03 3 s_1A3B3X_1163 s_1DKGMO_450 23,04 4,92 41,12 lod 2,5668 7

1 Targeting

Analysis Start End Length Location Reliability Signal Peptide Cut Off Mitochondrion Cut Off Network Signal Peptide Length
TargetP 1 21   Secretory pathway 2 0.834 0.033 NON-PLANT 21