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GO:0007165
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signal transduction
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The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
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GO:0007186
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G-protein coupled receptor signaling pathway
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A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576). |
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GO:0051716
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cellular response to stimulus
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Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell. |
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GO:0044699
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single-organism process
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A biological process that involves only one organism. |
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GO:0009987
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cellular process
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Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. |
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GO:0008150
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biological_process
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Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end. |
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GO:0044763
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single-organism cellular process
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Any process that is carried out at the cellular level, occurring within a single organism. |
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GO:0050896
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response to stimulus
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Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. |
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GO:0065007
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biological regulation
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Any process that modulates a measurable attribute of any biological process, quality or function. |
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GO:0050794
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regulation of cellular process
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Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. |
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GO:0050789
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regulation of biological process
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Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. |
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GO:0007154
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cell communication
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Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. |
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GO:0044700
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single organism signaling
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A signaling process occurring within a single organism. |
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GO:0023052
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signaling
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The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered. |
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GO:0044707
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single-multicellular organism process
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A biological process occurring within a single, multicellular organism. |
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GO:0032501
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multicellular organismal process
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Any biological process, occurring at the level of a multicellular organism, pertinent to its function. |
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GO:0003008
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system process
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A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective. |
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GO:0003013
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circulatory system process
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A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism. |
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GO:0003015
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heart process
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A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. |
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GO:0003012
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muscle system process
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A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers. |
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GO:0007187
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G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
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The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide. |
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GO:0007188
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adenylate cyclase-modulating G-protein coupled receptor signaling pathway
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The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP (cAMP). |
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GO:0007189
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adenylate cyclase-activating G-protein coupled receptor signaling pathway
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The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP). |
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GO:0090075
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relaxation of muscle
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A process in which the extent of muscle contraction is reduced. Muscle relaxation can involve a number of processes including the removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases. In some muscles, calcium-independent pathways also play a role in muscle relaxation by decreasing the phosphorylation state of myosin light chain. |
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GO:0055119
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relaxation of cardiac muscle
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The process in which the extent of cardiac muscle contraction is reduced. |
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GO:0071875
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adrenergic receptor signaling pathway
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A series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands. |
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GO:0071880
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adenylate cyclase-activating adrenergic receptor signaling pathway
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The series of molecular signals generated as a consequence of an adrenergic receptor binding to its physiological ligand, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP). |
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GO:0086023
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adrenergic receptor signaling pathway involved in heart process
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A series of molecular signals beginning with a G-protein coupled adrenergic cell surface receptor combining with epinephrine or norepinephrine, which contributes to a circulatory system process carried out by the heart. |
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GO:0086103
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G-protein coupled receptor signaling pathway involved in heart process
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An G-protein coupled receptor signaling pathway which contributes to a circulatory system process carried out by the heart. |
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GO:0086030
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adrenergic receptor signaling pathway involved in cardiac muscle relaxation
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An adrenergic receptor signaling pathway that contributes to a reduction in cardiac muscle contraction. Beta-adrenergic receptor-induced cardiac relaxation is achieved by a GPCR-activated adenylate cyclase generating cAMP; cAMP then activates the cAMP-dependent protein kinase A (PKA), which phosphorylates the sarcoplasmic reticulum (SR) membrane protein PLB. In its non-phosphorylated state, PLB acts as an inhibitor of the ATPase Ca(2+) pump of the cardiac SR (SERCA2a); inhibition of the pump is relieved upon phosphorylation. The pump removes Ca(2+) from the cytoplasm, thereby preventing cytosolic Ca(2+)-dependent activation of contractile proteins, leading to enhanced muscle relaxation. |
