GO Term : GO:0070782 phosphatidylserine exposure on apoptotic cell surface GO

Namespace  biological_process Obsolete  false
description  A phospholipid scrambling process that results in the appearance of phosphatidylserine on the outer leaflet of the plasma membrane of an apoptotic cell, which acts as an 'eat-me' signal for engulfing cells. Phosphatidylserine is exposed on the apoptotic cell surface by a phospholipid scramblase activity.

0 Cross References

1 Ontology

Name
GO

20 Parents

Identifier Name Description
GO:0044699 single-organism process A biological process that involves only one organism.
GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0016043 cellular component organization A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.
GO:0071840 cellular component organization or biogenesis A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component.
GO:0008150 biological_process Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO:0044763 single-organism cellular process Any process that is carried out at the cellular level, occurring within a single organism.
GO:0065007 biological regulation Any process that modulates a measurable attribute of any biological process, quality or function.
GO:0044802 single-organism membrane organization A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane, involving only one organism.
GO:0061024 membrane organization A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
GO:0065008 regulation of biological quality Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.
GO:0010256 endomembrane system organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system.
GO:0007009 plasma membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane.
GO:0006915 apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
GO:0008219 cell death Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as "apoptotic bodies"); and/or (3) its corpse (or its fragments) have been engulfed by an adjacent cell in vivo.
GO:0016265 death A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism.
GO:0012501 programmed cell death A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.
GO:0097194 execution phase of apoptosis A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
GO:0017121 phospholipid scrambling The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet, resulting in loss of lipid asymmetry and surface exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE).
GO:0097035 regulation of membrane lipid distribution Any process that modulates the proportions or spatial arrangement of lipids in a cellular membrane.
GO:0070782 phosphatidylserine exposure on apoptotic cell surface A phospholipid scrambling process that results in the appearance of phosphatidylserine on the outer leaflet of the plasma membrane of an apoptotic cell, which acts as an 'eat-me' signal for engulfing cells. Phosphatidylserine is exposed on the apoptotic cell surface by a phospholipid scramblase activity.

0 Protein

25 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
part of GO:0097194 GO:0070782
is_a GO:0017121 GO:0070782
is_a GO:0008150 GO:0070782
is_a GO:0065007 GO:0070782
is_a GO:0065008 GO:0070782
part of GO:0071840 GO:0070782
is_a GO:0097035 GO:0070782
part of GO:0044763 GO:0070782
is_a GO:0071840 GO:0070782
is_a GO:0044763 GO:0070782
part of GO:0008150 GO:0070782
is_a GO:0007009 GO:0070782
part of GO:0009987 GO:0070782
is_a GO:0016043 GO:0070782
part of GO:0016043 GO:0070782
is_a GO:0061024 GO:0070782
is_a GO:0044802 GO:0070782
is_a GO:0009987 GO:0070782
part of GO:0006915 GO:0070782
part of GO:0008219 GO:0070782
part of GO:0044699 GO:0070782
part of GO:0012501 GO:0070782
part of GO:0010256 GO:0070782
is_a GO:0044699 GO:0070782
part of GO:0016265 GO:0070782

1 Synonyms

Name Type
externalization of phosphatidylserine synonym