GO Term : GO:0070266 necroptotic process GO

Namespace  biological_process Obsolete  false
description  A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former.

0 Cross References

1 Ontology

Name
GO

10 Parents

Identifier Name Description
GO:0044699 single-organism process A biological process that involves only one organism.
GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0008150 biological_process Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO:0044763 single-organism cellular process Any process that is carried out at the cellular level, occurring within a single organism.
GO:0008219 cell death Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as "apoptotic bodies"); and/or (3) its corpse (or its fragments) have been engulfed by an adjacent cell in vivo.
GO:0016265 death A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism.
GO:0012501 programmed cell death A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.
GO:0070265 necrotic cell death A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues.
GO:0070266 necroptotic process A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former.
GO:0097300 programmed necrotic cell death A necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors.

0 Protein

20 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
regulates GO:0070266 GO:0060544
positively regulates GO:0070266 GO:0060545
regulates GO:0070266 GO:0060545
negatively regulates GO:0070266 GO:0060546
regulates GO:0070266 GO:0060546
is_a GO:0097300 GO:0070266
is_a GO:0016265 GO:0070266
is_a GO:0070265 GO:0070266
is_a GO:0009987 GO:0070266
is_a GO:0008150 GO:0070266
is_a GO:0044699 GO:0070266
is_a GO:0008219 GO:0070266
is_a GO:0012501 GO:0070266
is_a GO:0044763 GO:0070266
part of GO:0070266 GO:0097527
part of GO:0070266 GO:0097528
part of GO:0070266 GO:1901026
regulates GO:0070266 GO:1902442
regulates GO:0070266 GO:1902443
negatively regulates GO:0070266 GO:1902443

16 Synonyms

Name Type
induction of necroptosis of activated-T cells synonym
induction of necroptosis by extracellular signals synonym
programmed necrotic cell death synonym
necroptosis synonym
GO:0060553 alt_id
TNF-induced necroptosis synonym
GO:0060555 alt_id
GO:0060554 alt_id
activation of necroptosis by extracellular signals synonym
activation of necroptosis synonym
activation of necroptosis of activated-T cells synonym
activation of necroptosis in response to extracellular signals synonym
establishment of necroptosis of activated-T cells synonym
establishment of necroptosis synonym
induction of necroptosis synonym
extracellular signal-induced necroptosis synonym