GO Term : GO:0051870 methotrexate binding GO

Namespace  molecular_function Obsolete  false
description  Interacting selectively and non-covalently with methotrexate, an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate reductase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.

0 Cross References

1 Ontology

Name
GO

12 Parents

Identifier Name Description
GO:0005488 binding The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
GO:0008144 drug binding Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
GO:0003674 molecular_function Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
GO:1901363 heterocyclic compound binding Interacting selectively and non-covalently with heterocyclic compound.
GO:0097159 organic cyclic compound binding Interacting selectively and non-covalently with an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure.
GO:0043168 anion binding Interacting selectively and non-covalently with anions, charged atoms or groups of atoms with a net negative charge.
GO:0043167 ion binding Interacting selectively and non-covalently with ions, charged atoms or groups of atoms.
GO:0036094 small molecule binding Interacting selectively and non-covalently with a small molecule, any low molecular weight, monomeric, non-encoded molecule.
GO:0033218 amide binding Interacting selectively and non-covalently with an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group.
GO:0031406 carboxylic acid binding Interacting selectively and non-covalently with a carboxylic acid, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).
GO:0043177 organic acid binding Interacting selectively and non-covalently with an organic acid, any acidic compound containing carbon in covalent linkage.
GO:0051870 methotrexate binding Interacting selectively and non-covalently with methotrexate, an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate reductase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.

0 Protein

11 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0008144 GO:0051870
is_a GO:1901363 GO:0051870
is_a GO:0031406 GO:0051870
is_a GO:0033218 GO:0051870
is_a GO:0097159 GO:0051870
is_a GO:0003674 GO:0051870
is_a GO:0005488 GO:0051870
is_a GO:0036094 GO:0051870
is_a GO:0043167 GO:0051870
is_a GO:0043168 GO:0051870
is_a GO:0043177 GO:0051870

0 Synonyms