GO Term : GO:0048102 autophagic cell death GO

Namespace  biological_process Obsolete  false
description  A form of programmed cell death that is accompanied by macroautophagy, which is characterized by the sequestration of cytoplasmic material within autophagosomes for bulk degradation by lysosomes. Autophagic cell death is characterized by lack of chromatin condensation, massive vacuolization of the cytoplasm, and accumulation of (double-membraned) autophagosomes, with little or no uptake by phagocytic cells.

0 Cross References

1 Ontology

Name
GO

8 Parents

Identifier Name Description
GO:0044699 single-organism process A biological process that involves only one organism.
GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0008150 biological_process Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO:0044763 single-organism cellular process Any process that is carried out at the cellular level, occurring within a single organism.
GO:0008219 cell death Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as "apoptotic bodies"); and/or (3) its corpse (or its fragments) have been engulfed by an adjacent cell in vivo.
GO:0016265 death A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism.
GO:0012501 programmed cell death A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.
GO:0048102 autophagic cell death A form of programmed cell death that is accompanied by macroautophagy, which is characterized by the sequestration of cytoplasmic material within autophagosomes for bulk degradation by lysosomes. Autophagic cell death is characterized by lack of chromatin condensation, massive vacuolization of the cytoplasm, and accumulation of (double-membraned) autophagosomes, with little or no uptake by phagocytic cells.

0 Protein

14 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0048102 GO:0035071
part of GO:0048102 GO:0035072
is_a GO:0012501 GO:0048102
is_a GO:0044699 GO:0048102
is_a GO:0009987 GO:0048102
is_a GO:0008219 GO:0048102
is_a GO:0008150 GO:0048102
is_a GO:0016265 GO:0048102
is_a GO:0044763 GO:0048102
regulates GO:0048102 GO:1904092
negatively regulates GO:0048102 GO:1904093
regulates GO:0048102 GO:1904093
positively regulates GO:0048102 GO:1904094
regulates GO:0048102 GO:1904094

4 Synonyms

Name Type
type II programmed cell death synonym
autophagic death synonym
programmed cell death by autophagy synonym
programmed cell death by macroautophagy synonym