| Analysis | rpsblast_cdd | Start | 74 |
| End | 297 | Strand | + |
| Length | 224 | Note | Gaps:18 |
| Hit Coverage | 99.13 | Hit Length | 230 |
| Hit Pident | 30.70 | E Val | 1e-34 |
| Hit Description | pfam02602 HEM4 Uroporphyrinogen-III synthase HemD. This family consists of uroporphyrinogen-III synthase HemD EC:4.2.1.75 also known as Hydroxymethylbilane hydrolyase (cyclizing) from eukaryotes bacteria and archaea. This enzyme catalyzes the reaction: Hydroxymethylbilane < > uroporphyrinogen-III + H(2)O. Some members of this family are multi-functional proteins possessing other enzyme activities related to porphyrin biosynthesis such as hemD from Clostridium josui with pfam00590 however the aligned region corresponds with the uroporphyrinogen-III synthase EC:4.2.1.75 activity only. Uroporphyrinogen-III synthase is the fourth enzyme in the heme pathway. Mutant forms of the Uroporphyrinogen-III synthase gene cause congenital erythropoietic porphyria in humans a recessive inborn error of metabolism also known as Gunther disease. | Hit Pcons | 14.47 |
| Name | Qrob_P0738120.2 |
| Protein Identifier |
Organism . Name |
Score | Score Type | Protein Description | Alias (in v1) | Code Enzyme | Gene Prediction Quality |
|---|---|---|---|---|---|---|---|
| Qrob_P0738120.2 | Quercus robur | 100.0 | egn | (M=1) 4.2.1.75 - Uroporphyrinogen-III synthase. | EC:4.2.1.75 | validated |
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