Protein : Qrob_P0738120.2 Q. robur
Protein Identifier  ? Qrob_P0738120.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=1) 4.2.1.75 - Uroporphyrinogen-III synthase. Code Enzyme  EC:4.2.1.75
Gene Prediction Quality  validated Protein length 

Sequence

Length: 311  
Kegg Orthology  K01719
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0 Synonyms

2 GO Terms

Identifier Name Description
GO:0033014 tetrapyrrole biosynthetic process The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.
GO:0004852 uroporphyrinogen-III synthase activity Catalysis of the reaction: hydroxymethylbilane = H(2)O + uroporphyrinogen III.

19 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|pxb:103957047 1 310 + 310 Gaps:22 100.00 298 73.83 2e-148 uroporphyrinogen-III synthase chloroplastic-like
blastp_kegg lcl|pper:PRUPE_ppa008920mg 37 307 + 271 Gaps:4 86.94 314 79.49 3e-147 hypothetical protein
blastp_kegg lcl|pxb:103959538 36 307 + 272 Gaps:2 91.28 298 77.21 2e-146 uroporphyrinogen-III synthase chloroplastic-like
blastp_kegg lcl|pmum:103320285 37 307 + 271 Gaps:3 91.58 297 78.68 3e-146 uroporphyrinogen-III synthase chloroplastic
blastp_kegg lcl|cit:102622450 62 310 + 249 Gaps:2 83.11 302 81.67 1e-145 uroporphyrinogen-III synthase chloroplastic-like
blastp_kegg lcl|vvi:100250675 38 310 + 273 Gaps:5 88.82 304 77.41 5e-144 uroporphyrinogen-III synthase chloroplastic-like
blastp_kegg lcl|tcc:TCM_033898 38 310 + 273 Gaps:7 90.55 307 74.46 5e-142 Uroporphyrinogen-III synthase family protein isoform 1
blastp_kegg lcl|pop:POPTR_0014s03400g 15 308 + 294 Gaps:4 98.65 296 72.26 5e-140 uroporphyrinogen-3 synthase family protein
blastp_kegg lcl|fve:101313861 37 310 + 274 Gaps:7 94.39 285 78.44 1e-139 uroporphyrinogen-III synthase chloroplastic-like
blastp_kegg lcl|mdm:103455996 36 295 + 260 Gaps:1 92.23 283 74.71 1e-138 uroporphyrinogen-III synthase chloroplastic
blastp_uniprot_sprot sp|O48721|HEM4_ARATH 62 307 + 246 Gaps:2 76.64 321 72.36 2e-123 Uroporphyrinogen-III synthase chloroplastic OS Arabidopsis thaliana GN UROS PE 2 SV 2
blastp_uniprot_sprot sp|Q10QR9|HEM4_ORYSJ 63 307 + 245 Gaps:2 81.13 302 67.76 5e-116 Uroporphyrinogen-III synthase chloroplastic OS Oryza sativa subsp. japonica GN UROS PE 2 SV 1
blastp_uniprot_sprot sp|Q59294|HEM4_CLOJO 57 285 + 229 Gaps:18 45.83 504 26.84 6e-11 Porphyrin biosynthesis protein HemD OS Clostridium josui GN hemD PE 3 SV 1
rpsblast_cdd gnl|CDD|119440 63 300 + 238 Gaps:17 100.00 239 30.96 3e-37 cd06578 HemD Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes bacteria and archaea. Mutations in the human uroporphyrinogen-III synthase gene cause congenital erythropoietic porphyria a recessive inborn error of metabolism also known as Gunther disease.
rpsblast_cdd gnl|CDD|202304 74 297 + 224 Gaps:18 99.13 230 30.70 1e-34 pfam02602 HEM4 Uroporphyrinogen-III synthase HemD. This family consists of uroporphyrinogen-III synthase HemD EC:4.2.1.75 also known as Hydroxymethylbilane hydrolyase (cyclizing) from eukaryotes bacteria and archaea. This enzyme catalyzes the reaction: Hydroxymethylbilane < > uroporphyrinogen-III + H(2)O. Some members of this family are multi-functional proteins possessing other enzyme activities related to porphyrin biosynthesis such as hemD from Clostridium josui with pfam00590 however the aligned region corresponds with the uroporphyrinogen-III synthase EC:4.2.1.75 activity only. Uroporphyrinogen-III synthase is the fourth enzyme in the heme pathway. Mutant forms of the Uroporphyrinogen-III synthase gene cause congenital erythropoietic porphyria in humans a recessive inborn error of metabolism also known as Gunther disease.
rpsblast_cdd gnl|CDD|180313 62 305 + 244 Gaps:21 97.59 249 31.28 2e-30 PRK05928 hemD uroporphyrinogen-III synthase Reviewed.
rpsblast_cdd gnl|CDD|31775 62 305 + 244 Gaps:18 98.39 248 32.79 3e-28 COG1587 HemD Uroporphyrinogen-III synthase [Coenzyme metabolism].
rpsblast_cdd gnl|CDD|180782 63 154 + 92 none 14.02 656 29.35 7e-08 PRK06975 PRK06975 bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase Reviewed.
rpsblast_kog gnl|CDD|39335 74 307 + 234 Gaps:21 92.69 260 20.75 3e-07 KOG4132 KOG4132 KOG4132 Uroporphyrinogen III synthase UROS/HEM4 [Coenzyme transport and metabolism].

9 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Phobius 1 24 24 SIGNAL_PEPTIDE none Signal peptide region none
Phobius 5 12 8 SIGNAL_PEPTIDE_H_REGION none Hydrophobic region of a signal peptide. none
SUPERFAMILY 62 305 244 SSF69618 "KEGG:00860+4.2.1.75","MetaCyc:PWY-5188","MetaCyc:PWY-5189","UniPathway:UPA00251" none IPR003754
Pfam 74 297 224 PF02602 "KEGG:00860+4.2.1.75","MetaCyc:PWY-5188","MetaCyc:PWY-5189","UniPathway:UPA00251" Uroporphyrinogen-III synthase HemD IPR003754
Phobius 1 4 4 SIGNAL_PEPTIDE_N_REGION none N-terminal region of a signal peptide. none
Gene3D 65 184 120 G3DSA:3.40.50.10090 none none none
Gene3D 193 307 115 G3DSA:3.40.50.10090 none none none
Phobius 13 24 12 SIGNAL_PEPTIDE_C_REGION none C-terminal region of a signal peptide. none
Phobius 25 310 286 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none

1 Localization

Analysis Start End Length
SignalP_GRAM_POSITIVE 1 21 20

0 Qtllist

0 Targeting