| Analysis | rpsblast_cdd | Start | 120 |
| End | 300 | Strand | + |
| Length | 181 | Note | Gaps:8 |
| Hit Coverage | 87.75 | Hit Length | 204 |
| Hit Pident | 16.76 | E Val | 1e-07 |
| Hit Description | cd01335 Radical_SAM Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif which coordinates the conserved iron-sulfur cluster. Mechanistically they share the transfer of a single electron from the iron-sulfur cluster to SAM which leads to its reductive cleavage to methionine and a 5'-deoxyadenosyl radical which in turn abstracts a hydrogen from the appropriately positioned carbon atom. Depending on the enzyme SAM is consumed during this process or it is restored and reused. Radical SAM enzymes catalyze steps in metabolism DNA repair the biosynthesis of vitamins and coenzymes and the biosynthesis of many antibiotics. Examples are biotin synthase (BioB) lipoyl synthase (LipA) pyruvate formate-lyase (PFL) coproporphyrinogen oxidase (HemN) lysine 2 3-aminomutase (LAM) anaerobic ribonucleotide reductase (ARR) and MoaA an enzyme of the biosynthesis of molybdopterin.. | Hit Pcons | 20.11 |
| Name | Qrob_P0637150.2 |
| Protein Identifier |
Organism . Name |
Score | Score Type | Protein Description | Alias (in v1) | Code Enzyme | Gene Prediction Quality |
|---|---|---|---|---|---|---|---|
| Qrob_P0637150.2 | Quercus robur | 98.0 | egn | (M=2) 2.8.1.8 - Lipoyl synthase. | EC:2.8.1.8 | validated |
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