Blast Analysis : gnl|CDD|190619

Analysis  rpsblast_cdd Start  532
End  966 Strand  +
Length  435 Note  Gaps:8
Hit Coverage  100.00 Hit Length  435
Hit Pident  42.99 E Val  1e-155
Hit Description  pfam03378 CAS_CSE1 CAS/CSE protein C-terminus. Mammalian cellular apoptosis susceptibility (CAS) proteins are homologous to the yeast chromosome-segregation protein CSE1. This family aligns the C-terminal halves (approximately). CAS is involved in both cellular apoptosis and proliferation. Apoptosis is inhibited in CAS-depleted cells while the expression of CAS correlates to the degree of cellular proliferation. Like CSE1 it is essential for the mitotic checkpoint in the cell cycle (CAS depletion blocks the cell in the G2 phase) and has been shown to be associated with the microtubule network and the mitotic spindle as is the protein MEK which is thought to regulate the intracellular localisation (predominantly nuclear vs. predominantly cytosolic) of CAS. In the nucleus CAS acts as a nuclear transport factor in the importin pathway. The importin pathway mediates the nuclear transport of several proteins that are necessary for mitosis and further progression. CAS is therefore thought to affect the cell cycle through its effect on the nuclear transport of these proteins. Since apoptosis also requires the nuclear import of several proteins (such as P53 and transcription factors) it has been suggested that CAS also enables apoptosis by facilitating the nuclear import of at least a subset of these essential proteins. Hit Pcons  18.62
Name  Qrob_P0410820.2
Paste the following link
Lists
This BlastAnalysis isn't in any lists. Upload a list.

1 Protein

Protein Identifier
Organism . Name 		Score Score Type Protein Description Alias (in v1) Code Enzyme Gene Prediction Quality
Qrob_P0410820.2 Quercus robur 100.0 egn (M=1) KOG1241//KOG1991//KOG1992//KOG1993//KOG2171//KOG2274 - Karyopherin (importin) beta 1 [Nuclear structure Intracellular trafficking secretion and vesicular transport]. // Nuclear transport receptor RANBP7/RANBP8 (importin beta superfamily) [Nuclear structure Intracellular trafficking secretion and vesicular transport]. // Nuclear export receptor CSE1/CAS (importin beta superfamily) [Nuclear structure Intracellular trafficking secretion and vesicular transport]. // Nuclear transport receptor KAP120 (importin beta superfamily) [Nuclear structure Intracellular trafficking secretion and vesicular transport]. // Karyopherin (importin) beta 3 [Nuclear structure Intracellular trafficking secretion and vesicular transport]. // Predicted importin 9 [Intracellular trafficking secretion and vesicular transport Nuclear structure].     validated