Protein : Qrob_P0410820.2 Q. robur
Protein Identifier  ? Qrob_P0410820.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=1) KOG1241//KOG1991//KOG1992//KOG1993//KOG2171//KOG2274 - Karyopherin (importin) beta 1 [Nuclear structure Intracellular trafficking secretion and vesicular transport]. // Nuclear transport receptor RANBP7/RANBP8 (importin beta superfamily) [Nuclear structure Intracellular trafficking secretion and vesicular transport]. // Nuclear export receptor CSE1/CAS (importin beta superfamily) [Nuclear structure Intracellular trafficking secretion and vesicular transport]. // Nuclear transport receptor KAP120 (importin beta superfamily) [Nuclear structure Intracellular trafficking secretion and vesicular transport]. // Karyopherin (importin) beta 3 [Nuclear structure Intracellular trafficking secretion and vesicular transport]. // Predicted importin 9 [Intracellular trafficking secretion and vesicular transport Nuclear structure]. Gene Prediction Quality  validated
Protein length 

Sequence

Length: 976  
Kegg Orthology  K18423
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0 Synonyms

4 GO Terms

Identifier Name Description
GO:0005515 protein binding Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
GO:0005488 binding The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
GO:0008536 Ran GTPase binding Interacting selectively and non-covalently with Ran, a conserved Ras-like GTP-binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly.

34 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|cmo:103483177 1 974 + 974 Gaps:8 99.90 977 81.35 0.0 exportin-2
blastp_kegg lcl|csv:101208601 1 974 + 974 Gaps:8 99.90 977 81.15 0.0 exportin-2-like
blastp_kegg lcl|tcc:TCM_005128 1 975 + 975 Gaps:10 100.00 977 80.35 0.0 Cellular apoptosis susceptibility protein / importin-alpha re-exporter putative isoform 1
blastp_kegg lcl|gmx:100801426 1 975 + 975 Gaps:13 100.00 962 79.31 0.0 exportin-2-like
blastp_kegg lcl|gmx:100806017 1 975 + 975 Gaps:13 100.00 962 78.90 0.0 exportin-2-like
blastp_kegg lcl|cam:101492715 1 975 + 975 Gaps:11 100.00 970 78.35 0.0 exportin-2-like
blastp_kegg lcl|mdm:103439366 1 974 + 974 Gaps:5 99.90 970 78.43 0.0 exportin-2
blastp_kegg lcl|pxb:103929309 1 975 + 975 Gaps:6 100.00 971 78.78 0.0 exportin-2-like
blastp_kegg lcl|pxb:103964225 1 975 + 975 Gaps:6 100.00 971 78.78 0.0 exportin-2
blastp_kegg lcl|mdm:103417637 1 975 + 975 Gaps:6 100.00 971 78.89 0.0 exportin-2-like
blastp_pdb 1wa5_C 27 967 + 941 Gaps:52 97.60 960 29.88 3e-122 mol:protein length:960 IMPORTIN ALPHA RE-EXPORTER
blastp_pdb 1z3h_B 27 967 + 941 Gaps:52 96.80 968 29.88 3e-122 mol:protein length:968 Importin alpha re-exporter
blastp_pdb 1z3h_A 27 967 + 941 Gaps:52 96.80 968 29.88 3e-122 mol:protein length:968 Importin alpha re-exporter
blastp_uniprot_sprot sp|Q9ZPY7|XPO2_ARATH 1 974 + 974 Gaps:9 99.90 972 73.33 0.0 Exportin-2 OS Arabidopsis thaliana GN CAS PE 2 SV 1
blastp_uniprot_sprot sp|Q8AY73|XPO2_ORENI 1 966 + 966 Gaps:28 99.90 971 40.93 0.0 Exportin-2 OS Oreochromis niloticus GN cse1l PE 2 SV 1
blastp_uniprot_sprot sp|Q9PTU3|XPO2_PAGMA 1 966 + 966 Gaps:28 99.90 971 40.52 0.0 Exportin-2 OS Pagrus major GN cse1l PE 2 SV 1
blastp_uniprot_sprot sp|A5D785|XPO2_BOVIN 1 966 + 966 Gaps:28 99.90 971 40.31 0.0 Exportin-2 OS Bos taurus GN CSE1L PE 2 SV 1
blastp_uniprot_sprot sp|Q6GMY9|XPO2_XENLA 1 970 + 970 Gaps:24 99.07 971 39.71 0.0 Exportin-2 OS Xenopus laevis GN cse1l PE 2 SV 1
blastp_uniprot_sprot sp|P55060|XPO2_HUMAN 1 966 + 966 Gaps:28 99.90 971 40.21 0.0 Exportin-2 OS Homo sapiens GN CSE1L PE 1 SV 3
blastp_uniprot_sprot sp|Q9ERK4|XPO2_MOUSE 1 966 + 966 Gaps:28 99.90 971 40.10 0.0 Exportin-2 OS Mus musculus GN Cse1l PE 2 SV 1
blastp_uniprot_sprot sp|Q7SZC2|XPO2_DANRE 1 966 + 966 Gaps:28 99.90 971 40.10 0.0 Exportin-2 OS Danio rerio GN cse1l PE 2 SV 1
blastp_uniprot_sprot sp|Q5R9J2|XPO2_PONAB 1 966 + 966 Gaps:28 99.90 971 40.00 0.0 Exportin-2 OS Pongo abelii GN CSE1L PE 2 SV 1
blastp_uniprot_sprot sp|Q9XZU1|XPO2_DROME 1 974 + 974 Gaps:20 99.90 975 36.04 0.0 Exportin-2 OS Drosophila melanogaster GN Cas PE 2 SV 2
rpsblast_cdd gnl|CDD|190619 532 966 + 435 Gaps:8 100.00 435 42.99 1e-155 pfam03378 CAS_CSE1 CAS/CSE protein C-terminus. Mammalian cellular apoptosis susceptibility (CAS) proteins are homologous to the yeast chromosome-segregation protein CSE1. This family aligns the C-terminal halves (approximately). CAS is involved in both cellular apoptosis and proliferation. Apoptosis is inhibited in CAS-depleted cells while the expression of CAS correlates to the degree of cellular proliferation. Like CSE1 it is essential for the mitotic checkpoint in the cell cycle (CAS depletion blocks the cell in the G2 phase) and has been shown to be associated with the microtubule network and the mitotic spindle as is the protein MEK which is thought to regulate the intracellular localisation (predominantly nuclear vs. predominantly cytosolic) of CAS. In the nucleus CAS acts as a nuclear transport factor in the importin pathway. The importin pathway mediates the nuclear transport of several proteins that are necessary for mitosis and further progression. CAS is therefore thought to affect the cell cycle through its effect on the nuclear transport of these proteins. Since apoptosis also requires the nuclear import of several proteins (such as P53 and transcription factors) it has been suggested that CAS also enables apoptosis by facilitating the nuclear import of at least a subset of these essential proteins.
rpsblast_cdd gnl|CDD|117083 163 531 + 369 Gaps:7 100.00 370 47.57 1e-144 pfam08506 Cse1 Cse1. This domain is present in Cse1 nuclear export receptor proteins. Cse1 mediates the nuclear export of importin alpha. This domain contains HEAT repeats.
rpsblast_cdd gnl|CDD|35216 20 966 + 947 Gaps:62 98.10 947 23.90 3e-93 COG5657 CSE1 CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning].
rpsblast_cdd gnl|CDD|35215 11 968 + 958 Gaps:93 99.48 970 19.48 1e-26 COG5656 SXM1 Importin protein involved in nuclear import [Posttranslational modification protein turnover chaperones].
rpsblast_cdd gnl|CDD|202774 29 105 + 77 Gaps:8 100.00 71 30.99 1e-07 pfam03810 IBN_N Importin-beta N-terminal domain.
rpsblast_kog gnl|CDD|37203 6 970 + 965 Gaps:18 99.90 960 46.92 0.0 KOG1992 KOG1992 KOG1992 Nuclear export receptor CSE1/CAS (importin beta superfamily) [Nuclear structure Intracellular trafficking secretion and vesicular transport].
rpsblast_kog gnl|CDD|37202 8 969 + 962 Gaps:194 98.81 1010 19.94 7e-38 KOG1991 KOG1991 KOG1991 Nuclear transport receptor RANBP7/RANBP8 (importin beta superfamily) [Nuclear structure Intracellular trafficking secretion and vesicular transport].

11 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
SUPERFAMILY 1 968 968 SSF48371 none none IPR016024
Pfam 532 965 434 PF03378 none CAS/CSE protein, C-terminus IPR005043
Pfam 29 104 76 PF03810 none Importin-beta N-terminal domain IPR001494
ProSiteProfiles 29 105 77 PS50166 none Importin-beta N-terminal domain profile. IPR001494
Gene3D 3 878 876 G3DSA:1.25.10.10 none none IPR011989
Gene3D 917 966 50 G3DSA:1.25.10.10 none none IPR011989
PANTHER 1 953 953 PTHR10997:SF8 none none none
Pfam 163 531 369 PF08506 none Cse1 IPR013713
SMART 29 105 77 SM00913 none Importin-beta N-terminal domain IPR001494
Pfam 109 147 39 PF08389 none Exportin 1-like protein IPR013598
PANTHER 1 953 953 PTHR10997 none none none

0 Localization

10 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran2_2014_nLBD*_A4 Qrob_Chr08 8 v_12498_318 v_12364_308 34,91 16,12 53,62 lod 2,4961 5,2
Bourran2_2014_nSecLBD_3P Qrob_Chr08 8 s_1BN2OD_551 s_1B5AYF_599 17,17 0 43,51 lod 1,9229 4,4
Bourran2_2014_rEpiBC*_A4 Qrob_Chr08 8 v_12498_318 v_12364_308 35,77 14,11 55,31 lod 2,9413 6,2
Bourran2_2015_nEpiBC_3P Qrob_Chr12 12 s_1B73S5_217 v_7050_211 28,31 26,37 28,45 lod 4.5 11.6
Bourran2_2014_aSeqBC_A4 Qrob_Chr08 8 v_15999_278 v_AP13YL15_395 32,52 4,22 57,22 lod 2,7561 6,7
Bourran2_2014_nFork*_A4 Qrob_Chr08 8 PIE175 s_1CD7GJ_1398 31,22 5,24 57,24 lod 2,6724 6,8
Bourran2_2014_nPriLBD_A4 Qrob_Chr08 8 PIE175 v_9164_159 31,85 15,39 48,29 lod 2,8308 6,8
Bourran2_2015_rEpiBC_3P Qrob_Chr08 8 s_A9TNV_543 v_11837_70 9,93 9,83 11,15 lod 3.3 7.3
Champenoux_2015_nSeqBC_A4 Qrob_Chr08 8 v_AD7YD13_501 s_1A7IED_780 43,44 43,42 43,99 lod 3.7 8.9
NancyGreenhouseCO2_2001_ambient_elevated_leaf_cellulose_QTL3_d13Cf Qrob_Chr08 8 v_5216_549 v_11625_20 37.08 12,26 54,9 lod 6.5888 0.04

0 Targeting