Blast Analysis : gnl|CDD|99822

Analysis  rpsblast_cdd Start  821
End  894 Strand  +
Length  74 Note  none
Hit Coverage  36.27 Hit Length  204
Hit Pident  71.62 E Val  5e-34
Hit Description  cd05779 DNA_polB_epsilon_exo DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase epsilon a family-B DNA polymerase. The 3'-5' exonuclease domain of eukaryotic DNA polymerase epsilon. DNA polymerase epsilon is a family-B DNA polymerase with a catalytic subunit that contains a DEDDy-type DnaQ-like 3'-5' exonuclease domain. It is one of the three DNA-dependent type B DNA polymerases (alpha and delta are the other two) that have been identified as essential for nuclear DNA replication in eukaryotes. DNA polymerase epsilon plays a role in elongating the leading strand during DNA replication. It is also involved in DNA repair. The catalytic subunit contains both polymerase and 3'-5' exonuclease activities. The N-terminal exonuclease domain contains three sequence motifs termed ExoI ExoII and ExoIII with a specific YX(3)D pattern at ExoIII. These motifs are clustered around the active site and are involved in metal binding and catalysis. DNA polymerase epsilon also carries a unique large C-terminal domain with an unknown function. Phylogenetic analyses indicate that it is orthologous to the archaeal DNA polymerase B3 rather than to the eukaryotic alpha delta or zeta polymerases. The exonuclease domain of family-B polymerases contains a beta hairpin structure that plays an important role in active site switching in the event of nucleotide misincorporation. Hit Pcons  6.76
Name  Qrob_P0332710.2
Paste the following link
Lists
This BlastAnalysis isn't in any lists. Upload a list.

1 Protein

Protein Identifier
Organism . Name 		Score Score Type Protein Description Alias (in v1) Code Enzyme Gene Prediction Quality
Qrob_P0332710.2 Quercus robur 28.0 egn (M=1) KOG0132//KOG0260//KOG0307//KOG0916//KOG1049//KOG1798//KOG1830//KOG1984//KOG1985//KOG3671 - RNA polymerase II C-terminal domain-binding protein RA4 contains RPR and RRM domains [RNA processing and modification Transcription]. // RNA polymerase II large subunit [Transcription]. // Vesicle coat complex COPII subunit SEC31 [Intracellular trafficking secretion and vesicular transport]. // 1 3-beta-glucan synthase/callose synthase catalytic subunit [Cell wall/membrane/envelope biogenesis]. // Polyadenylation factor I complex subunit FIP1 [RNA processing and modification]. // DNA polymerase epsilon catalytic subunit A [Replication recombination and repair]. // Wiskott Aldrich syndrome proteins [Cytoskeleton]. // Vesicle coat complex COPII subunit SFB3 [Intracellular trafficking secretion and vesicular transport]. // Vesicle coat complex COPII subunit SEC24/subunit SFB2 [Intracellular trafficking secretion and vesicular transport]. // Actin regulatory protein (Wiskott-Aldrich syndrome protein) [Signal transduction mechanisms Cytoskeleton].   EC:2.4.1.34 validated