| Analysis | rpsblast_cdd | Start | 60 |
| End | 213 | Strand | + |
| Length | 154 | Note | Gaps:42 |
| Hit Coverage | 60.47 | Hit Length | 215 |
| Hit Pident | 31.54 | E Val | 6e-12 |
| Hit Description | cd00497 PseudoU_synth_TruA_like Pseudouridine synthase TruA family. This group consists of eukaryotic bacterial and archeal pseudouridine synthases similar to Escherichia coli TruA Saccharomyces cerevisiae Pus1p S. cerevisiae Pus3p Caenorhabditis elegans Pus1p and human PUS1. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil psi). No cofactors are required. S. cerevisiae PUS1 catalyzes the formation of psi34 and psi36 in the intron containing tRNAIle psi35 in the intron containing tRNATyr psi27 and/or psi28 in several yeast cytoplasmic tRNAs and psi44 in U2 small nuclear RNA (U2 snRNA). The presence of the intron is required for the formation of psi 34 35 and 36. In addition S. cerevisiae PUS1 makes psi 26 65 and 67. C. elegans Pus1p does not modify psi44 in U2 snRNA. S. cerevisiae Pus3p makes psi38 and psi39 in tRNAs. Psi44 in U2 snRNA and psi38 and psi39 in tRNAs are highly phylogenetically conserved. Psi 26 27 28 34 35 36 65 and 67 in tRNAs are less highly conserved. Mouse Pus1p regulates nuclear receptor activity through pseudouridylation of Steroid Receptor RNA Activator. Missense mutation in human PUS1 causes mitochondrial myopathy and sideroblastic anemia (MLASA). | Hit Pcons | 13.85 |
| Name | Qrob_P0280300.2 |
| Protein Identifier |
Organism . Name |
Score | Score Type | Protein Description | Alias (in v1) | Code Enzyme | Gene Prediction Quality |
|---|---|---|---|---|---|---|---|
| Qrob_P0280300.2 | Quercus robur | 100.0 | egn | (M=1) 4.2.1.70//5.4.99.12 - Pseudouridylate synthase. // tRNA pseudouridine(38-40) synthase. | EC:5.4.99.12, EC:4.2.1.70 | validated |
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