| Analysis | rpsblast_cdd | Start | 58 |
| End | 386 | Strand | + |
| Length | 329 | Note | Gaps:26 |
| Hit Coverage | 100.00 | Hit Length | 245 |
| Hit Pident | 39.18 | E Val | 9e-43 |
| Hit Description | cd02568 PseudoU_synth_PUS1_PUS2 Pseudouridine synthase PUS1/ PUS2 like. This group consists of eukaryotic pseudouridine synthases similar to Saccharomyces cerevisiae Pus1p S. cerevisiae Pus2p Caenorhabditis elegans Pus1p and human PUS1. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil psi). No cofactors are required. S. cerevisiae Pus1p catalyzes the formation of psi34 and psi36 in the intron-containing tRNAIle psi35 in the intron-containing tRNATyr psi27 and/or psi28 in several yeast cytoplasmic tRNAs and psi44 in U2 small nuclear RNA (U2 snRNA). The presence of the intron is required for the formation of psi 34 35 and 36. In addition S. cerevisiae PUS1 makes are psi 26 65 and 67. C. elegans Pus1p does not modify psi44 in U2 snRNA. Mouse Pus1p makes psi27/28 in pre- tRNASer tRNAVal and tRNAIle psi 34/36 in tRNAIle and psi 32 and potentially 67 in tRNAVal. Psi44 in U2 snRNA and psi32 in tRNAs are highly phylogenetically conserved. Psi 26 27 28 34 35 36 65 and 67 in tRNAs are less highly conserved. Mouse Pus1p regulates nuclear receptor activity through pseudouridylation of Steroid Receptor RNA Activator. Missense mutation in human PUS1 causes mitochondrial myopathy and sideroblastic anemia (MLASA). | Hit Pcons | 16.33 |
| Name | Qrob_P0280300.2 |
| Protein Identifier |
Organism . Name |
Score | Score Type | Protein Description | Alias (in v1) | Code Enzyme | Gene Prediction Quality |
|---|---|---|---|---|---|---|---|
| Qrob_P0280300.2 | Quercus robur | 100.0 | egn | (M=1) 4.2.1.70//5.4.99.12 - Pseudouridylate synthase. // tRNA pseudouridine(38-40) synthase. | EC:5.4.99.12, EC:4.2.1.70 | validated |
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