| Analysis | rpsblast_cdd | Start | 18 |
| End | 276 | Strand | + |
| Length | 259 | Note | Gaps:24 |
| Hit Coverage | 94.10 | Hit Length | 288 |
| Hit Pident | 30.63 | E Val | 2e-24 |
| Hit Description | cd08063 MPN_CSN6 Mpr1p Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity found in COP9 signalosome complex subunit 6. CSN6 (COP9 signalosome subunit 6 COP9 subunit 6 MOV34 homolog 34 kD) is one of the eight subunits of COP9 signalosome a highly conserved protein complex with diverse functions including several important intracellular pathways such as the ubiquitin/proteasome system DNA repair cell cycle developmental changes and some aspects of immune responses. CSN6 is an MPN-domain protein that directly interacts with the MPN+-domain subunit CSN5. It is cleaved during apoptosis by activated caspases. CSN6 processing occurs in CSN/CRL (cullin-RING Ub ligase) complexes and is followed by the cleavage of Rbx1 the direct interaction partner of CSN6. CSN6 cleavage enhances CSN-mediated deneddylating activity (i.e. cleavage of ubiquitin-like protein Nedd8 (neural precursor cell expressed developmentally downregulated 8)) in the cullin 1 in cells. The cleavage of Rbx1 and increased deneddylation of cullins inactivate CRLs and presumably stabilize pro-apoptotic factors for final apoptotic steps. While CSN6 shows a typical MPN metalloprotease fold it lacks the canonical JAMM motif and therefore does not show catalytic isopeptidase activity. | Hit Pcons | 18.45 |
| Name | Qrob_P0236660.2 |
| Protein Identifier |
Organism . Name |
Score | Score Type | Protein Description | Alias (in v1) | Code Enzyme | Gene Prediction Quality |
|---|---|---|---|---|---|---|---|
| Qrob_P0236660.2 | Quercus robur | 100.0 | egn | (M=1) K03249 - translation initiation factor eIF-3 subunit 5 | validated |
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