| Analysis | rpsblast_cdd | Start | 20 |
| End | 177 | Strand | + |
| Length | 158 | Note | Gaps:15 |
| Hit Coverage | 100.00 | Hit Length | 157 |
| Hit Pident | 30.57 | E Val | 9e-28 |
| Hit Description | cd08057 MPN_euk_non_mb Mpr1p Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity (non metal-binding) eukaryotic. This family contains MPN (also known as Mov34 PAD-1 JAMM JAB MPN+) domains variants lacking key residues in the JAB1/MPN/Mov34 metalloenzyme (JAMM) motif and are unable to coordinate a metal ion. Comparisons of key catalytic and metal binding residues explain why the MPN-containing proteins Rpn7/PSMD7 Rpn8/PSMD8 CSN6 Prp8p and the translation initiation factor 3 subunits f and h do not show catalytic isopeptidase activity. It has been proposed that the MPN domain in these proteins has a primarily structural function. Rpn7 is known to be critical for the integrity of the 26S proteasome complex by establishing a correct lid structure. It is necessary for the incorporation/anchoring of Rpn3 and Rpn12 to the lid and essential for viability and normal mitosis. CSN6 is a highly conserved protein complex with diverse functions including several important intracellular pathways such as the ubiquitin/proteasome system DNA repair cell cycle developmental changes and some aspects of immune responses. It cleaves ubiquitin-like protein Nedd8 (neural precursor cell expressed developmentally downregulated 8)) in the cullin 1 in cells. EIF3f s a potent inhibitor of HIV-1 replication as well as an important negative regulator of cell growth and proliferation. EIF3h regulates cell growth and viability and that over-expression of the gene may provide growth advantage to prostate breast and liver cancer cells. | Hit Pcons | 19.11 |
| Name | Qrob_P0236660.2 |
| Protein Identifier |
Organism . Name |
Score | Score Type | Protein Description | Alias (in v1) | Code Enzyme | Gene Prediction Quality |
|---|---|---|---|---|---|---|---|
| Qrob_P0236660.2 | Quercus robur | 100.0 | egn | (M=1) K03249 - translation initiation factor eIF-3 subunit 5 | validated |
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