Blast Analysis : gnl|CDD|132846

Analysis  rpsblast_cdd Start  232
End  394 Strand  +
Length  163 Note  Gaps:11
Hit Coverage  87.63 Hit Length  194
Hit Pident  22.35 E Val  4e-12
Hit Description  cd07207 Pat_ExoU_VipD_like ExoU and VipD-like proteins homologus to patatin cPLA2 and iPLA2. ExoU a 74-kDa enzyme is a potent virulence factor of Pseudomonas aeruginosa. One of the pathogenic mechanisms of P. aeruginosa is to induce cytotoxicity by the injection of effector proteins (e.g. ExoU) using the type III secretion (T3S) system. ExoU is homologus to patatin and also has the conserved catalytic residues of mammalian calcium-independent (iPLA2) and cytosolic (cPLA2) PLA2. In vitro ExoU cytotoxity is blocked by the inhibitor of cytosolic and Ca2-independent phospholipase A2 (cPLA2 and iPLA2) enzymes suggesting that phospholipase A2 inhibitors may represent a novel mode of treatment for acute P. aeruginosa infections. ExoU requires eukaryotic superoxide dismutase as a cofactor and cleaves phosphatidylcholine and phosphatidylethanolamine in vitro. VipD a 69-kDa cytosolic protein belongs to the members of Legionella pneumophila family and is homologus to ExoU from Pseudomonas. Even though VipD shows high sequence similarity with several functional regions of ExoU (e.g. oxyanion hole active site serine active site aspartate) it has been shown to have no phospholipase activity. This family includes ExoU from Pseudomonas aeruginosa and VipD of Legionella pneumophila. Hit Pcons  23.53
Name  Qrob_P0225690.2
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1 Protein

Protein Identifier
Organism . Name 		Score Score Type Protein Description Alias (in v1) Code Enzyme Gene Prediction Quality
Qrob_P0225690.2 Quercus robur 100.0 egn (M=1) K14674 - TAG lipase / steryl ester hydrolase / phospholipase A2 / LPA acyltransferase [EC:3.1.1.3 3.1.1.13 3.1.1.4 2.3.1.51]   EC:3.1.1.3 validated