Protein : Qrob_P0225690.2 Q. robur
Protein Identifier  ? Qrob_P0225690.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=1) K14674 - TAG lipase / steryl ester hydrolase / phospholipase A2 / LPA acyltransferase [EC:3.1.1.3 3.1.1.13 3.1.1.4 2.3.1.51] Code Enzyme  EC:3.1.1.3
Gene Prediction Quality  validated Protein length 

Sequence

Length: 844  
Kegg Orthology  K14674
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0 Synonyms

3 GO Terms

Identifier Name Description
GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
GO:0004806 triglyceride lipase activity Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate.

31 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|pmum:103339243 1 842 + 842 Gaps:9 99.88 850 82.69 0.0 triacylglycerol lipase SDP1
blastp_kegg lcl|pper:PRUPE_ppa001336mg 1 842 + 842 Gaps:9 99.88 850 82.21 0.0 hypothetical protein
blastp_kegg lcl|mdm:103436385 1 835 + 835 Gaps:9 99.76 844 81.71 0.0 triacylglycerol lipase SDP1
blastp_kegg lcl|fve:101298727 1 840 + 840 Gaps:17 98.95 858 80.92 0.0 triacylglycerol lipase SDP1-like
blastp_kegg lcl|vvi:100258980 1 818 + 818 Gaps:11 97.06 850 83.88 0.0 triacylglycerol lipase SDP1-like
blastp_kegg lcl|tcc:TCM_024457 1 834 + 834 Gaps:10 99.18 849 80.29 0.0 Patatin-like phospholipase family protein isoform 1
blastp_kegg lcl|pxb:103940227 1 842 + 842 Gaps:10 99.88 851 80.47 0.0 triacylglycerol lipase SDP1-like
blastp_kegg lcl|cam:101509590 3 843 + 841 Gaps:10 98.47 852 81.41 0.0 triacylglycerol lipase SDP1-like
blastp_kegg lcl|mdm:103415051 1 842 + 842 Gaps:11 99.88 852 79.32 0.0 triacylglycerol lipase SDP1-like
blastp_kegg lcl|pxb:103933970 1 842 + 842 Gaps:11 99.88 852 79.20 0.0 triacylglycerol lipase SDP1-like
blastp_uniprot_sprot sp|Q9LZA6|SDP1_ARATH 1 804 + 804 Gaps:40 95.27 825 77.61 0.0 Triacylglycerol lipase SDP1 OS Arabidopsis thaliana GN SDP1 PE 1 SV 1
blastp_uniprot_sprot sp|P36165|TGL4_YEAST 108 568 + 461 Gaps:46 52.20 910 34.95 3e-71 Lipase 4 OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN TGL4 PE 1 SV 1
blastp_uniprot_sprot sp|Q12043|TGL5_YEAST 108 568 + 461 Gaps:45 64.09 749 32.92 3e-70 Lipase 5 OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN TGL5 PE 1 SV 1
blastp_uniprot_sprot sp|Q9Y827|YEX5_SCHPO 105 561 + 457 Gaps:30 95.03 483 34.64 3e-66 Uncharacterized protein C1A6.05c OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN SPAC1A6.05c PE 4 SV 1
blastp_uniprot_sprot sp|Q1DXR6|PLPL_COCIM 97 563 + 467 Gaps:58 66.16 730 33.13 2e-59 Patatin-like phospholipase domain-containing protein CIMG_04897 OS Coccidioides immitis (strain RS) GN CIMG_04897 PE 3 SV 1
blastp_uniprot_sprot sp|A1D4C8|PLPL_NEOFI 71 558 + 488 Gaps:74 72.19 712 33.27 8e-59 Patatin-like phospholipase domain-containing protein NFIA_019760 OS Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) GN NFIA_019760 PE 3 SV 1
blastp_uniprot_sprot sp|Q4WJS4|PLPL_ASPFU 71 558 + 488 Gaps:78 72.19 712 33.66 2e-58 Patatin-like phospholipase domain-containing protein AFUA_1G04970 OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) GN AFUA_1G04970 PE 3 SV 1
blastp_uniprot_sprot sp|O14115|PLPL_SCHPO 55 597 + 543 Gaps:55 87.62 630 30.62 2e-58 Patatin-like phospholipase domain-containing protein SPAC1786.01c OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN SPAC1786.01c PE 3 SV 2
blastp_uniprot_sprot sp|Q5BGC2|PLPL_EMENI 73 585 + 513 Gaps:80 69.56 749 33.01 5e-58 Patatin-like phospholipase domain-containing protein AN0408 OS Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) GN AN0408 PE 3 SV 1
blastp_uniprot_sprot sp|Q5AM72|PLPL_CANAL 72 563 + 492 Gaps:65 61.31 853 30.02 2e-56 Patatin-like phospholipase domain-containing protein CaO19.1504 OS Candida albicans (strain SC5314 / ATCC MYA-2876) GN CaO19.1504 PE 3 SV 1
rpsblast_cdd gnl|CDD|132869 162 569 + 408 Gaps:85 100.00 323 79.26 1e-167 cd07231 Pat_SDP1-like Sugar-Dependent 1 like lipase. Sugar-Dependent 1 (SDP1) lipase has a patatin-like acyl-hydrolase domain that initiates the breakdown of storage oil in germinating Arabidopsis seeds. This acyl-hydrolase domain is homologus to yeast triacylglycerol lipase 3 and human adipose triglyceride lipase. This family includes SDP1 from Arabidopsis thaliana.
rpsblast_cdd gnl|CDD|132845 162 563 + 402 Gaps:106 100.00 298 52.35 1e-118 cd07206 Pat_TGL3-4-5_SDP1 Triacylglycerol lipase 3 4 and 5 and Sugar-Dependent 1 lipase. Triacylglycerol lipases are involved in triacylglycerol mobilization and degradation they are found in lipid particles. TGL4 is 30% homologus to TGL3 whereas TGL5 is 26% homologus to TGL3. Sugar-Dependent 1 (SDP1) lipase has a patatin-like acyl-hydrolase domain that initiates the breakdown of storage oil in germinating Arabidopsis seeds. This family includes subfamilies of proteins: TGL3 TGL4 TGL5 and SDP1.
rpsblast_cdd gnl|CDD|132868 158 568 + 411 Gaps:31 99.29 421 40.91 1e-100 cd07230 Pat_TGL4-5_like Triacylglycerol lipase 4 and 5. TGL4 and TGL5 are triacylglycerol lipases that are involved in triacylglycerol mobilization and degradation they are found in lipid particles. Tgl4 is a functional ortholog of mammalian adipose TG lipase (ATGL) and is phosphorylated and activated by cyclin-dependent kinase 1 (Cdk1/Cdc28). TGL4 is 30% homologus to TGL3 whereas TGL5 is 26% homologus to TGL3. This family includes TGL4 (STC1) and TGL5 (STC2) from Saccharomyces cerevisiae.
rpsblast_cdd gnl|CDD|132870 187 564 + 378 Gaps:38 93.37 407 35.53 5e-80 cd07232 Pat_PLPL Patain-like phospholipase. Patatin-like phospholipase. This family consists of various patatin glycoproteins from plants and fungi. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein but it also has the enzymatic activity of a lipid acyl hydrolase catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have been found also in vertebrates.
rpsblast_cdd gnl|CDD|132867 153 564 + 412 Gaps:70 98.72 391 36.27 3e-66 cd07229 Pat_TGL3_like Triacylglycerol lipase 3. Triacylglycerol lipase 3 (TGL3) are responsible for all the TAG lipase activity of the lipid particle. Triacylglycerol (TAG) lipases are also necessary for the mobilization of TAG stored in lipid particles. TGL3 contains the consensus sequence motif GXSXG which is found in lipolytic enzymes. This family includes Tgl3p from Saccharomyces cerevisiae.
rpsblast_cdd gnl|CDD|192840 86 226 + 141 Gaps:8 100.00 145 37.93 4e-36 pfam11815 DUF3336 Domain of unknown function (DUF3336). This family of proteins are functionally uncharacterized. This family is found in bacteria and eukaryotes. This presumed domain is typically between 143 to 227 amino acids in length.
rpsblast_cdd gnl|CDD|132837 232 442 + 211 Gaps:79 100.00 172 33.72 6e-31 cd07198 Patatin Patatin-like phospholipase. Patatin is a storage protein of the potato tuber that shows Phospholipase A2 activity (PLA2 EC 3.1.1.4). Patatin catalyzes the nonspecific hydrolysis of phospholipids glycolipids sulfolipids and mono- and diacylglycerols thereby showing lipid acyl hydrolase activity. The active site includes an oxyanion hole with a conserved GGxR motif it is found in almost all the members of this family. The catalytic dyad is formed by a serine and an aspartate. Patatin belongs to the alpha-beta hydrolase family which is identified by a characteristic nucleophile elbow with a consensus sequence of Sm-X-Nu-Sm (Sm small residue X any residue and Nu nucleophile). Members of this family have been found also in vertebrates. This family includes PNPLA (1-9) TGL (3-5) ExoU-like and SDP1-like subfamilies. There are some additional hypothetical proteins included in this family.
rpsblast_cdd gnl|CDD|31938 224 452 + 229 Gaps:34 64.38 306 25.38 6e-18 COG1752 RssA Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only].
rpsblast_cdd gnl|CDD|201943 232 390 + 159 Gaps:12 89.42 189 27.22 2e-16 pfam01734 Patatin Patatin-like phospholipase. This family consists of various patatin glycoproteins from plants. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein but it also has the enzymatic activity of lipid acyl hydrolase catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have been found also in vertebrates.
rpsblast_cdd gnl|CDD|132846 232 394 + 163 Gaps:11 87.63 194 22.35 4e-12 cd07207 Pat_ExoU_VipD_like ExoU and VipD-like proteins homologus to patatin cPLA2 and iPLA2. ExoU a 74-kDa enzyme is a potent virulence factor of Pseudomonas aeruginosa. One of the pathogenic mechanisms of P. aeruginosa is to induce cytotoxicity by the injection of effector proteins (e.g. ExoU) using the type III secretion (T3S) system. ExoU is homologus to patatin and also has the conserved catalytic residues of mammalian calcium-independent (iPLA2) and cytosolic (cPLA2) PLA2. In vitro ExoU cytotoxity is blocked by the inhibitor of cytosolic and Ca2-independent phospholipase A2 (cPLA2 and iPLA2) enzymes suggesting that phospholipase A2 inhibitors may represent a novel mode of treatment for acute P. aeruginosa infections. ExoU requires eukaryotic superoxide dismutase as a cofactor and cleaves phosphatidylcholine and phosphatidylethanolamine in vitro. VipD a 69-kDa cytosolic protein belongs to the members of Legionella pneumophila family and is homologus to ExoU from Pseudomonas. Even though VipD shows high sequence similarity with several functional regions of ExoU (e.g. oxyanion hole active site serine active site aspartate) it has been shown to have no phospholipase activity. This family includes ExoU from Pseudomonas aeruginosa and VipD of Legionella pneumophila.

6 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
PANTHER 1 652 652 PTHR14226:SF27 none none none
PANTHER 1 652 652 PTHR14226 none none none
SUPERFAMILY 228 573 346 SSF52151 none none IPR016035
Gene3D 260 396 137 G3DSA:3.40.1090.10 none none none
Pfam 232 425 194 PF01734 none Patatin-like phospholipase IPR002641
Pfam 89 225 137 PF11815 none Domain of unknown function (DUF3336) IPR021771

0 Localization

13 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran2_2014_nLBD*_A4 Qrob_Chr08 8 v_12498_318 v_12364_308 34,91 16,12 53,62 lod 2,4961 5,2
Bourran2_2014_nPriLBD_3P Qrob_Chr08 8 v_5216_549 v_11837_70 12,36 0 30,43 lod 2,5806 5,1
Bourran2_2014_nEpis*_A4 Qrob_Chr07 7 v_12400_446 s_1BPEBU_1211 6,93 0 15,13 lod 4,7411 11
Bourran2_2014_nSecLBD_A4 Qrob_Chr07 7 v_8327_222 s_1A4WGY_363 16,04 0 44,69 lod 2,6373 6,5
Bourran2_2014_nP_A4 Qrob_Chr11 11 s_1B58GB_1413 s_1A5BYY_1671 11,15 0 42,38 lod 1,8913 4,5
Bourran2_2014_nP_3P Qrob_Chr11 11 v_11486_194 s_1AT3E_2335 7,9 0,09 30,09 lod 2,3636 5
Bourran2_2015_nEpis_A4 Qrob_Chr09 9 v_15847_485 v_8329_369 34,94 34,88 37,45 lod 3.1 7
Bourran2_2015_nEpiBC_A4 Qrob_Chr07 7 s_1DP9TW_798 v_8128_173 22,61 22,14 22,73 lod 3.1 8.5
Bourran2_2014_nEpiBC_A4 Qrob_Chr07 7 s_2FI9D9_500 s_1AXDMJ_325 12,26 0 34,9 lod 2,2306 6,1
Bourran2_2014_nPriBD_3P Qrob_Chr11 11 v_11486_194 s_1AT3E_2335 5,54 0,4 20,6 lod 2,6345 5,9
Bourran2_2002_QTL10_peak_Bud_burst_3P Qrob_Chr07 7 s_1CAWP_311 s_1BEZ9M_461 7,5 0 21,5 lod 3,7 6,3
Bourran2_2014_nPriBD*_A4 Qrob_Chr07 7 s_1A7UI0_596 s_1A3H6S_352 8,02 0 20,53 lod 4,1062 10,8
Bourran2_2014_nPriLBD*_A4 Qrob_Chr07 7 s_1C6BY7_802 s_1BPEBU_1211 7,15 0 16,34 lod 3,9419 10,2

0 Targeting