Blast Analysis : gnl|CDD|176877

Analysis	rpsblast_cdd	Start	48
End	228	Strand	+
Length	181	Note	Gaps:12
Hit Coverage	87.02	Hit Length	208
Hit Pident	23.76	E Val	8e-09
Hit Description	cd08868 START_STARD1_3_like Cholesterol-binding START domain of mammalian STARD1 -3 and related proteins. This subfamily includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of STARD1 (also known as StAR) and STARD3 (also known as metastatic lymph node 64/MLN64). The START domain family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. This STARD1-like subfamily has a high affinity for cholesterol. STARD1/StAR can reduce macrophage lipid content and inflammatory status. It plays an essential role in steroidogenic tissues: transferring the steroid precursor cholesterol from the outer to the inner mitochondrial membrane across the aqueous space. Mutations in the gene encoding STARD1/StAR can cause lipid congenital adrenal hyperplasia (CAH) an autosomal recessive disorder characterized by a steroid synthesis deficiency and an accumulation of cholesterol in the adrenal glands and the gonads. STARD3 may function in trafficking endosomal cholesterol to a cytosolic acceptor or membrane. In addition to having a cytoplasmic START cholesterol-binding domain STARD3 also contains an N-terminal MENTAL cholesterol-binding and protein-protein interaction domain. The MENTAL domain contains transmembrane helices and anchors MLN64 to endosome membranes. The gene encoding STARD3 is overexpressed in about 25% of breast cancers.	Hit Pcons	21.55
Name	Qrob_P0110250.2

1 Protein

Protein Identifier	Organism . Name	Score	Score Type	Protein Description	Alias (in v1)	Code Enzyme	Gene Prediction Quality
Qrob_P0110250.2	Quercus robur	100.0	egn	(M=3) PTHR19308:SF9 - MEMBRANE RELATED PROTEIN-LIKE (PTHR19308:SF9)			validated

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