Protein : Qrob_P0110250.2 Q. robur
Protein Identifier  ? Qrob_P0110250.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=3) PTHR19308:SF9 - MEMBRANE RELATED PROTEIN-LIKE (PTHR19308:SF9) Gene Prediction Quality  validated
Protein length 

Sequence

Length: 240  
Paste the following link
Lists
This Protein isn't in any lists. Upload a list.

Sequence Feature Displayer

Protein Sequence Displayer

J Browse Displayer

0 Synonyms

1 GO Terms

Identifier Name Description
GO:0008289 lipid binding Interacting selectively and non-covalently with a lipid.

21 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|cit:102607802 5 239 + 235 none 99.16 237 92.77 8e-160 uncharacterized LOC102607802
blastp_kegg lcl|cic:CICLE_v10002337mg 5 239 + 235 none 99.16 237 92.34 2e-158 hypothetical protein
blastp_kegg lcl|vvi:100265982 5 239 + 235 none 97.51 241 91.06 4e-158 uncharacterized LOC100265982
blastp_kegg lcl|pop:POPTR_0004s23990g 1 238 + 238 Gaps:2 99.59 241 90.83 2e-157 hypothetical protein
blastp_kegg lcl|pvu:PHAVU_003G090300g 5 238 + 234 Gaps:1 98.31 237 92.27 3e-156 hypothetical protein
blastp_kegg lcl|gmx:100806061 3 238 + 236 Gaps:1 94.76 248 91.49 9e-156 PCTP-like protein-like
blastp_kegg lcl|gmx:100812234 3 238 + 236 Gaps:1 78.33 300 89.79 2e-154 PCTP-like protein-like
blastp_kegg lcl|rcu:RCOM_1298940 5 238 + 234 Gaps:1 98.74 238 91.06 3e-154 hypothetical protein
blastp_kegg lcl|pmum:103318929 5 238 + 234 Gaps:9 97.59 249 86.83 6e-152 stAR-related lipid transfer protein 5
blastp_kegg lcl|fve:101291634 5 239 + 235 Gaps:5 99.17 242 87.92 4e-151 stAR-related lipid transfer protein 5-like
blastp_uniprot_sprot sp|Q9JMD3|PCTL_MOUSE 50 233 + 184 Gaps:12 61.17 291 24.72 2e-10 PCTP-like protein OS Mus musculus GN Stard10 PE 1 SV 1
blastp_uniprot_sprot sp|Q9Y365|PCTL_HUMAN 50 233 + 184 Gaps:12 61.17 291 24.72 3e-10 PCTP-like protein OS Homo sapiens GN STARD10 PE 1 SV 2
blastp_uniprot_sprot sp|P97826|STAR_RAT 46 234 + 189 Gaps:10 66.55 284 26.46 2e-06 Steroidogenic acute regulatory protein mitochondrial OS Rattus norvegicus GN Star PE 1 SV 1
rpsblast_cdd gnl|CDD|176851 44 232 + 189 Gaps:9 95.34 193 27.72 3e-33 cd00177 START Lipid-binding START domain of mammalian STARD1-STARD15 and related proteins. This family includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15 and related domains such as the START domain of the Arabidopsis homeobox protein GLABRA 2. The mammalian STARDs are grouped into 8 subfamilies. This family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. For some members of this family specific lipids that bind in this pocket are known these include cholesterol (STARD1/STARD3/ STARD4/STARD5) 25-hydroxycholesterol (STARD5) phosphatidylcholine (STARD2/ STARD7/STARD10) phosphatidylethanolamine (STARD10) and ceramides (STARD11). The START domain is found either alone or in association with other domains. Mammalian STARDs participate in the control of various cellular processes including lipid trafficking between intracellular compartments lipid metabolism and modulation of signaling events. Mutation or altered expression of STARDs is linked to diseases such as cancer genetic disorders and autoimmune disease. The Arabidopsis homeobox protein GLABRA 2 suppresses root hair formation in hairless epidermal root cells.
rpsblast_cdd gnl|CDD|176885 35 231 + 197 Gaps:12 98.97 195 22.80 3e-14 cd08876 START_1 Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family. Functionally uncharacterized subgroup of the START domain family. The START domain family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. For some mammalian members of the START family (STARDs) it is known which lipids bind in this pocket these include cholesterol (STARD1 -3 -4 and -5) 25-hydroxycholesterol (STARD5) phosphatidylcholine (STARD2 -7 and -10) phosphatidylethanolamine (STARD10) and ceramides (STARD11). Mammalian STARDs participate in the control of various cellular processes including lipid trafficking between intracellular compartments lipid metabolism and modulation of signaling events. Mutation or altered expression of STARDs is linked to diseases such as cancer genetic disorders and autoimmune disease.
rpsblast_cdd gnl|CDD|176880 45 234 + 190 Gaps:18 83.78 222 27.96 7e-14 cd08871 START_STARD10-like Lipid-binding START domain of mammalian STARD10 and related proteins. This subfamily includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD10 (also known as CGI-52 PTCP-like and SDCCAG28). The START domain family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. STARD10 binds phophatidylcholine and phosphatidylethanolamine. This protein is widely expressed and is synthesized constitutively in many organs. It may function in the liver in the export of phospholipids into bile. It is concentrated in the sperm flagellum and may play a role in energy metabolism. In the mammary gland it may participate in the enrichment of lipids in milk and be a potential marker of differentiation. Its expression is induced in this gland during gestation and lactation. It is overexpressed in mammary tumors from Neu/ErbB2 transgenic mice in several breast carcinoma cell lines and in 35% of primary human breast cancers and may cooperate with c-erbB receptor signaling in breast oncogenesis. It is a potential marker of disease outcome in breast cancer loss of STARD10 expression in breast cancer strongly predicts an aggressive disease course. The lipid transfer activity of STRAD10 is downregulated by phosphorylation of its Ser284 by CK2 (casein kinase 2).
rpsblast_cdd gnl|CDD|176877 48 228 + 181 Gaps:12 87.02 208 23.76 8e-09 cd08868 START_STARD1_3_like Cholesterol-binding START domain of mammalian STARD1 -3 and related proteins. This subfamily includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of STARD1 (also known as StAR) and STARD3 (also known as metastatic lymph node 64/MLN64). The START domain family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. This STARD1-like subfamily has a high affinity for cholesterol. STARD1/StAR can reduce macrophage lipid content and inflammatory status. It plays an essential role in steroidogenic tissues: transferring the steroid precursor cholesterol from the outer to the inner mitochondrial membrane across the aqueous space. Mutations in the gene encoding STARD1/StAR can cause lipid congenital adrenal hyperplasia (CAH) an autosomal recessive disorder characterized by a steroid synthesis deficiency and an accumulation of cholesterol in the adrenal glands and the gonads. STARD3 may function in trafficking endosomal cholesterol to a cytosolic acceptor or membrane. In addition to having a cytoplasmic START cholesterol-binding domain STARD3 also contains an N-terminal MENTAL cholesterol-binding and protein-protein interaction domain. The MENTAL domain contains transmembrane helices and anchors MLN64 to endosome membranes. The gene encoding STARD3 is overexpressed in about 25% of breast cancers.
rpsblast_cdd gnl|CDD|197591 43 232 + 190 Gaps:10 92.68 205 22.11 1e-08 smart00234 START in StAR and phosphatidylcholine transfer protein. putative lipid-binding domain in StAR and phosphatidylcholine transfer protein.
rpsblast_cdd gnl|CDD|202011 28 215 + 188 Gaps:15 88.29 205 23.20 1e-08 pfam01852 START START domain.
rpsblast_cdd gnl|CDD|176876 46 228 + 183 Gaps:28 89.81 206 24.32 2e-07 cd08867 START_STARD4_5_6-like Lipid-binding START domain of mammalian STARD4 -5 -6 and related proteins. This subfamily includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD4 -5 and -6. The START domain family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. STARD4 plays an important role in steroidogenesis trafficking cholesterol into mitochondria. It specifically binds cholesterol and demonstrates limited binding to another sterol 7a-hydroxycholesterol. STARD4 and STARD5 are ubiquitously expressed with highest levels in liver and kidney. STRAD5 functions in the kidney within the proximal tubule cells where it is associated with the Endoplasmic Reticulum (ER) and may participate in ER-associated cholesterol transport. It binds cholesterol and 25-hydroxycholesterol. Expression of the gene encoding STARD5 is increased by ER stress and its mRNA and protein levels are elevated in a type I diabetic mouse model of human diabetic nephropathy. STARD6 is expressed in male germ cells of normal rats and in the steroidogenic Leydig cells of perinatal hypothyroid testes. It may play a pivotal role in the steroidogenesis as well as in the spermatogenesis of normal rats. STARD6 has also been detected in the rat nervous system and may participate in neurosteroid synthesis.
rpsblast_kog gnl|CDD|37972 43 233 + 191 Gaps:15 86.76 219 24.21 4e-09 KOG2761 KOG2761 KOG2761 START domain-containing proteins involved in steroidogenesis/phosphatidylcholine transfer [Lipid transport and metabolism].

6 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
PANTHER 19 232 214 PTHR19308 none none none
SUPERFAMILY 23 232 210 SSF55961 none none none
PANTHER 19 232 214 PTHR19308:SF9 none none none
ProSiteProfiles 44 213 170 PS50848 none START domain profile. IPR002913
Pfam 42 215 174 PF01852 none START domain IPR002913
Gene3D 31 234 204 G3DSA:3.30.530.20 none none IPR023393

0 Localization

0 Qtllist

0 Targeting