| Analysis | rpsblast_cdd | Start | 63 |
| End | 133 | Strand | + |
| Length | 71 | Note | Gaps:2 |
| Hit Coverage | 87.95 | Hit Length | 83 |
| Hit Pident | 34.25 | E Val | 9e-11 |
| Hit Description | cd00618 PLA2_like PLA2_like: Phospholipase A2 a super-family of secretory and cytosolic enzymes the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine) usually in a metal-dependent reaction to generate lysophospholipid (LysoPL) and a free fatty acid (FA). The resulting products are either dietary or used in synthetic pathways for leukotrienes and prostaglandins. Often arachidonic acid is released as a free fatty acid and acts as second messenger in signaling networks. Secreted PLA2s have also been found to specifically bind to a variety of soluble and membrane proteins in mammals including receptors. As a toxin PLA2 is a potent presynaptic neurotoxin which blocks nerve terminals by binding to the nerve membrane and hydrolyzing stable membrane lipids. The products of the hydrolysis (LysoPL and FA) cannot form bilayers leading to a change in membrane conformation and ultimately to a block in the release of neurotransmitters. PLA2 may form dimers or oligomers. | Hit Pcons | 4.11 |
| Name | Qrob_P0084200.2 |
| Protein Identifier |
Organism . Name |
Score | Score Type | Protein Description | Alias (in v1) | Code Enzyme | Gene Prediction Quality |
|---|---|---|---|---|---|---|---|
| Qrob_P0084200.2 | Quercus robur | 100.0 | egn | (M=1) K01047 - phospholipase A2 [EC:3.1.1.4] | EC:3.1.1.4 | validated |
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