Protein : Qrob_P0084200.2 Q. robur
Protein Identifier  ? Qrob_P0084200.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=1) K01047 - phospholipase A2 [EC:3.1.1.4] Code Enzyme  EC:3.1.1.4
Gene Prediction Quality  validated Protein length 

Sequence

Length: 159  
Kegg Orthology  K01047
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0 Synonyms

4 GO Terms

Identifier Name Description
GO:0005509 calcium ion binding Interacting selectively and non-covalently with calcium ions (Ca2+).
GO:0004623 phospholipase A2 activity Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.
GO:0016042 lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
GO:0006644 phospholipid metabolic process The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester.

26 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|tcc:TCM_039586 12 158 + 147 none 96.08 153 64.63 2e-63 Phospholipase A21
blastp_kegg lcl|vvi:100243777 7 158 + 152 none 100.00 152 62.50 2e-62 phospholipase A2 homolog 3-like
blastp_kegg lcl|pxb:103931618 1 158 + 158 Gaps:3 100.00 155 59.35 4e-61 phospholipase A2-alpha-like
blastp_kegg lcl|gmx:100787294 1 158 + 158 none 100.00 158 56.96 5e-61 phospholipase A2 homolog 3-like
blastp_kegg lcl|pxb:103959387 1 158 + 158 Gaps:3 100.00 155 58.71 5e-61 phospholipase A2-alpha-like
blastp_kegg lcl|pxb:103939520 1 158 + 158 Gaps:3 100.00 155 58.71 2e-60 phospholipase A2-alpha-like
blastp_kegg lcl|pxb:103937453 1 158 + 158 Gaps:3 100.00 155 58.71 2e-60 phospholipase A2-alpha-like
blastp_kegg lcl|pxb:103937452 1 158 + 158 Gaps:3 100.00 155 58.71 2e-60 phospholipase A2-alpha-like
blastp_kegg lcl|mdm:103404077 1 158 + 158 Gaps:3 100.00 155 58.71 2e-59 phospholipase A2-alpha
blastp_kegg lcl|gmx:100797904 1 158 + 158 Gaps:1 100.00 157 59.24 2e-59 phospholipase A2 homolog 3-like
blastp_pdb 2wg9_B 33 156 + 124 Gaps:6 95.38 130 53.23 2e-38 mol:protein length:130 PUTATIVE PHOSPHOLIPASE A2
blastp_pdb 2wg9_A 33 156 + 124 Gaps:6 95.38 130 53.23 2e-38 mol:protein length:130 PUTATIVE PHOSPHOLIPASE A2
blastp_pdb 2wg7_B 33 156 + 124 Gaps:6 95.38 130 53.23 2e-38 mol:protein length:130 PUTATIVE PHOSPHOLIPASE A2
blastp_pdb 2wg7_A 33 156 + 124 Gaps:6 95.38 130 53.23 2e-38 mol:protein length:130 PUTATIVE PHOSPHOLIPASE A2
blastp_pdb 2wg8_C 45 156 + 112 Gaps:3 84.50 129 55.96 2e-38 mol:protein length:129 PUTATIVE PHOSPHOLIPASE A2
blastp_pdb 2wg8_B 45 156 + 112 Gaps:3 84.50 129 55.96 2e-38 mol:protein length:129 PUTATIVE PHOSPHOLIPASE A2
blastp_pdb 2wg8_A 45 156 + 112 Gaps:3 84.50 129 54.13 1e-37 mol:protein length:129 PUTATIVE PHOSPHOLIPASE A2
blastp_uniprot_sprot sp|Q8S8N6|PLA2A_ARATH 18 158 + 141 none 95.27 148 59.57 4e-56 Phospholipase A2-alpha OS Arabidopsis thaliana GN PLA2-ALPHA PE 1 SV 1
blastp_uniprot_sprot sp|Q10E50|PLA23_ORYSJ 31 158 + 128 Gaps:2 77.30 163 54.76 2e-42 Phospholipase A2 homolog 3 OS Oryza sativa subsp. japonica GN PLA2-III PE 1 SV 1
blastp_uniprot_sprot sp|Q9XG81|PLA22_ORYSJ 9 156 + 148 Gaps:10 94.12 153 52.08 3e-38 Probable phospholipase A2 homolog 2 OS Oryza sativa subsp. japonica GN PLA2-II PE 1 SV 1
blastp_uniprot_sprot sp|Q9XG80|PLA21_ORYSJ 63 149 + 87 Gaps:3 60.87 138 45.24 3e-17 Probable phospholipase A2 homolog 1 OS Oryza sativa subsp. japonica GN PLA2-I PE 2 SV 1
blastp_uniprot_sprot sp|Q9M0D7|PLA2C_ARATH 40 122 + 83 Gaps:3 42.78 187 48.75 3e-15 Phospholipase A2-gamma OS Arabidopsis thaliana GN PLA2-GAMMA PE 1 SV 1
blastp_uniprot_sprot sp|Q8GV50|PLA2D_ARATH 40 122 + 83 Gaps:3 41.88 191 47.50 3e-15 Phospholipase A2-delta OS Arabidopsis thaliana GN PLA2-DELTA PE 2 SV 1
blastp_uniprot_sprot sp|Q8GZB4|PLA2B_ARATH 42 122 + 81 Gaps:3 53.06 147 42.31 1e-12 Phospholipase A2-beta OS Arabidopsis thaliana GN PLA2-BETA PE 1 SV 1
rpsblast_cdd gnl|CDD|153095 42 158 + 117 none 100.00 117 54.70 1e-37 cd04706 PLA2_plant PLA2_plant: Plant-specific sub-family of Phospholipase A2 a super-family of secretory and cytosolic enzymes the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids secreted PLA2s have also been found to specifically bind to a variety of soluble and membrane proteins in mammals including receptors. As a toxin PLA2 is a potent presynaptic neurotoxin which blocks nerve terminals by binding to the nerve membrane and hydrolyzing stable membrane lipids. The products of the hydrolysis cannot form bilayers leading to a change in membrane conformation and ultimately to a block in the release of neurotransmitters. PLA2 may form dimers or oligomers. This sub-family does not appear to have a conserved active site and metal-binding loop.
rpsblast_cdd gnl|CDD|153092 63 133 + 71 Gaps:2 87.95 83 34.25 9e-11 cd00618 PLA2_like PLA2_like: Phospholipase A2 a super-family of secretory and cytosolic enzymes the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine) usually in a metal-dependent reaction to generate lysophospholipid (LysoPL) and a free fatty acid (FA). The resulting products are either dietary or used in synthetic pathways for leukotrienes and prostaglandins. Often arachidonic acid is released as a free fatty acid and acts as second messenger in signaling networks. Secreted PLA2s have also been found to specifically bind to a variety of soluble and membrane proteins in mammals including receptors. As a toxin PLA2 is a potent presynaptic neurotoxin which blocks nerve terminals by binding to the nerve membrane and hydrolyzing stable membrane lipids. The products of the hydrolysis (LysoPL and FA) cannot form bilayers leading to a change in membrane conformation and ultimately to a block in the release of neurotransmitters. PLA2 may form dimers or oligomers.

10 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Phobius 10 21 12 SIGNAL_PEPTIDE_H_REGION none Hydrophobic region of a signal peptide. none
Phobius 1 9 9 SIGNAL_PEPTIDE_N_REGION none N-terminal region of a signal peptide. none
PANTHER 62 145 84 PTHR11716 "KEGG:00564+3.1.1.4","KEGG:00565+3.1.1.4","KEGG:00590+3.1.1.4","KEGG:00591+3.1.1.4","KEGG:00592+3.1.1.4","MetaCyc:PWY-6803","MetaCyc:PWY-7409","MetaCyc:PWY-7416","MetaCyc:PWY-7417";signature_desc=PHOSPHOLIPASE A2 none IPR001211
Gene3D 52 118 67 G3DSA:1.20.90.10 "KEGG:00564+3.1.1.4","KEGG:00565+3.1.1.4","KEGG:00590+3.1.1.4","KEGG:00591+3.1.1.4","KEGG:00592+3.1.1.4","MetaCyc:PWY-6803","MetaCyc:PWY-7409","MetaCyc:PWY-7416","MetaCyc:PWY-7417" none IPR016090
PANTHER 62 145 84 PTHR11716:SF49 none none none
Phobius 1 30 30 SIGNAL_PEPTIDE none Signal peptide region none
Phobius 31 158 128 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
ProSitePatterns 88 95 8 PS00118 "KEGG:00564+3.1.1.4","KEGG:00565+3.1.1.4","KEGG:00590+3.1.1.4","KEGG:00591+3.1.1.4","KEGG:00592+3.1.1.4","MetaCyc:PWY-6803","MetaCyc:PWY-7409","MetaCyc:PWY-7416","MetaCyc:PWY-7417" Phospholipase A2 histidine active site. IPR013090
Phobius 22 30 9 SIGNAL_PEPTIDE_C_REGION none C-terminal region of a signal peptide. none
SUPERFAMILY 62 132 71 SSF48619 "KEGG:00564+3.1.1.4","KEGG:00565+3.1.1.4","KEGG:00590+3.1.1.4","KEGG:00591+3.1.1.4","KEGG:00592+3.1.1.4","MetaCyc:PWY-6803","MetaCyc:PWY-7409","MetaCyc:PWY-7416","MetaCyc:PWY-7417" none IPR016090

1 Localization

Analysis Start End Length
SignalP_EUK 1 30 29

0 Qtllist

1 Targeting

Analysis Start End Length Location Reliability Signal Peptide Cut Off Mitochondrion Cut Off Network Signal Peptide Length
TargetP 1 30   Secretory pathway 1 0.951 0.022 NON-PLANT 30