| Analysis | rpsblast_cdd | Start | 178 |
| End | 327 | Strand | + |
| Length | 150 | Note | Gaps:9 |
| Hit Coverage | 100.00 | Hit Length | 143 |
| Hit Pident | 23.78 | E Val | 4e-09 |
| Hit Description | pfam01590 GAF GAF domain. This domain is present in cGMP-specific phosphodiesterases adenylyl and guanylyl cyclases phytochromes FhlA and NifA. Adenylyl and guanylyl cyclases catalyze ATP and GTP to the second messengers cAMP and cGMP respectively these products up-regulating catalytic activity by binding to the regulatory GAF domain(s). The opposite hydrolysis reaction is catalyzed by phosphodiesterase. cGMP-dependent 3' 5'-cyclic phosphodiesterase catalyzes the conversion of guanosine 3' 5'-cyclic phosphate to guanosine 5'-phosphate. Here too cGMP regulates catalytic activity by GAF-domain binding. Phytochromes are regulatory photoreceptors in plants and bacteria which exist in two thermally-stable states that are reversibly inter-convertible by light: the Pr state absorbs maximally in the red region of the spectrum while the Pfr state absorbs maximally in the far-red region. This domain is also found in FhlA (formate hydrogen lyase transcriptional activator) and NifA a transcriptional activator which is required for activation of most Nif operons which are directly involved in nitrogen fixation. NifA interacts with sigma-54. | Hit Pcons | 18.18 |
| Name | Qrob_P0049540.2 |
| Protein Identifier |
Organism . Name |
Score | Score Type | Protein Description | Alias (in v1) | Code Enzyme | Gene Prediction Quality |
|---|---|---|---|---|---|---|---|
| Qrob_P0049540.2 | Quercus robur | 91.0 | egn | (M=1) PF00512//PF01590 - His Kinase A (phospho-acceptor) domain // GAF domain | EC:2.7.11.1 | validated |
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