| Analysis | rpsblast_cdd | Start | 356 |
| End | 550 | Strand | + |
| Length | 195 | Note | Gaps:55 |
| Hit Coverage | 95.35 | Hit Length | 172 |
| Hit Pident | 32.32 | E Val | 9e-14 |
| Hit Description | pfam01612 DNA_pol_A_exo1 3'-5' exonuclease. This domain is responsible for the 3'-5' exonuclease proofreading activity of E. coli DNA polymerase I (polI) and other enzymes it catalyzes the hydrolysis of unpaired or mismatched nucleotides. This domain consists of the amino-terminal half of the Klenow fragment in E. coli polI it is also found in the Werner syndrome helicase (WRN) focus forming activity 1 protein (FFA-1) and ribonuclease D (RNase D). Werner syndrome is a human genetic disorder causing premature aging the WRN protein has helicase activity in the 3'-5' direction. The FFA-1 protein is required for formation of a replication foci and also has helicase activity it is a homologue of the WRN protein. RNase D is a 3'-5' exonuclease involved in tRNA processing. Also found in this family is the autoantigen PM/Scl thought to be involved in polymyositis-scleroderma overlap syndrome. | Hit Pcons | 22.56 |
| Name | Qrob_P0041030.2 |
| Protein Identifier |
Organism . Name |
Score | Score Type | Protein Description | Alias (in v1) | Code Enzyme | Gene Prediction Quality |
|---|---|---|---|---|---|---|---|
| Qrob_P0041030.2 | Quercus robur | 97.0 | egn | (M=1) PTHR13620:SF2 - gb def: cg6744 gene product [drosophila melanogaster] | EC:3.6.4.12 | validated |
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