Blast Analysis : gnl|CDD|192074

Analysis  rpsblast_cdd Start  569
End  645 Strand  +
Length  77 Note  Gaps:16
Hit Coverage  100.00 Hit Length  93
Hit Pident  31.18 E Val  4e-15
Hit Description  pfam08573 SAE2 DNA repair protein endonuclease SAE2/CtIP C-terminus. SAE2 is a protein involved in repairing meiotic and mitotic double-strand breaks in DNA. It has been shown to negatively regulate DNA damage checkpoint signalling. SAE2 is homologous to the CtIP proteins in mammals and an homologous protein in plants. Crucial sequence motifs that are highly conserved are the CxxC and the RHR motifs in this C-terminal part of the protein. It is now known to be an endonuclease. In budding yeast genetic evidence suggests that the SAE2 protein is essential for the processing of hairpin DNA intermediates and meiotic double-strand breaks by Mre11/Rad50 complexes. SAE2 binds DNA and exhibits endonuclease activity on single-stranded DNA independently of Mre11/Rad50 complexes but hairpin DNA structures are cleaved cooperatively in the presence of Mre11/Rad50 or Mre11/Rad50/Xrs2. Hairpin structures are not processed at the tip by SAE2 but rather at single-stranded DNA regions adjacent to the hairpin. The catalytic activities of SAE2 are important for its biological functions. Hit Pcons  13.98
Name  Qrob_P0038880.2
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1 Protein

Protein Identifier
Organism . Name 		Score Score Type Protein Description Alias (in v1) Code Enzyme Gene Prediction Quality
Qrob_P0038880.2 Quercus robur 0.0 egn (M=1) KOG0018//KOG0161//KOG0933//KOG0964//KOG0965//KOG0971//KOG0996//KOG1029 - Structural maintenance of chromosome protein 1 (sister chromatid cohesion complex Cohesin subunit SMC1) [Cell cycle control cell division chromosome partitioning]. // Myosin class II heavy chain [Cytoskeleton]. // Structural maintenance of chromosome protein 2 (chromosome condensation complex Condensin subunit E) [Chromatin structure and dynamics Cell cycle control cell division chromosome partitioning]. // Structural maintenance of chromosome protein 3 (sister chromatid cohesion complex Cohesin subunit SMC3) [Cell cycle control cell division chromosome partitioning]. // Predicted RNA-binding protein contains SWAP and G-patch domains [General function prediction only]. // Microtubule-associated protein dynactin DCTN1/Glued [Cell cycle control cell division chromosome partitioning Cytoskeleton]. // Structural maintenance of chromosome protein 4 (chromosome condensation complex Condensin subunit C) [Chromatin structure and dynamics Cell cycle control cell division chromosome partitioning]. // Endocytic adaptor protein intersectin [Signal transduction mechanisms Intracellular trafficking secretion and vesicular transport].     validated