| Analysis | rpsblast_cdd | Start | 38 |
| End | 138 | Strand | + |
| Length | 101 | Note | Gaps:28 |
| Hit Coverage | 100.00 | Hit Length | 121 |
| Hit Pident | 39.67 | E Val | 4e-28 |
| Hit Description | cd08378 C2B_MCTP_PRT_plant C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP) plant subset. MCTPs are involved in Ca2+ signaling at the membrane. Plant-MCTPs are composed of a variable N-terminal sequence four C2 domains two transmembrane regions (TMRs) and a short C-terminal sequence. It is one of four protein classes that are anchored to membranes via a transmembrane region the others being synaptotagmins extended synaptotagmins and ferlins. MCTPs are the only membrane-bound C2 domain proteins that contain two functional TMRs. MCTPs are unique in that they bind Ca2+ but not phospholipids. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids inositol polyphosphates and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain such as protein kinase C or membrane trafficking proteins which contain at least two C2 domains such as synaptotagmin 1. However there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues primarily aspartates that serve as ligands for calcium ions. This cd contains the second C2 repeat C2B and has a type-II topology. | Hit Pcons | 16.53 |
| Name | Qrob_P0031880.2 |
| Protein Identifier |
Organism . Name |
Score | Score Type | Protein Description | Alias (in v1) | Code Enzyme | Gene Prediction Quality |
|---|---|---|---|---|---|---|---|
| Qrob_P0031880.2 | Quercus robur | 0.0 | egn | (M=13) PTHR10024:SF201 - C2 CALCIUM/LIPID-BINDING PLANT PHOSPHORIBOSYLTRANSFERASE-LIKE PROTEIN (PTHR10024:SF201) | validated |
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